Bacteriemia en daño hepático crónico

Munita, José M.; B, Rafael Araos; G, Jorge Pérez; Álvarez, Alejandra; C, Magdalena Canals; B, Jorge Conteras; S, Alejandra Marcotti; M., Luis Thompson; R, Luis M Noriega

doi:10.4067/s0716-10182011000100006

Cited by 5 publications

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“…On the contrary, Staphylococcus spp. are the most common Grampositive bacteria found in patients with LC and bacteremia [17,64,65,67,68,70]. Several studies reported no significant differences in either the severity of liver dysfunction or short-term prognosis between patients with bacteremia induced by Gram-positive bacteria and those infected with Gram-negative bacteria [64][65][66].…”

Section: Causative Organisms Detected In Patients With Lc and Bacteremiamentioning

confidence: 99%

“…Susceptibility to bacteremia [2,15,28,64,67,71,72] and the subsequent short-term prognosis [64,69,70,72,73] in patients with LC are correlated with the severity of LC, which is an independent risk factor for mortality in patients with LC and bacteremia [17]. Moreover, the possibility of the development of renal impairment is significantly higher among patients with bacteremia than among those with negative blood culture [68].…”

Section: Predictors Of Susceptibility and Prognosis In Patients With ...mentioning

confidence: 99%

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Spontaneous Bacterial Peritonitis and Bacteremia in Patients with Liver Cirrhosis

Shizuma

2014

J Med Microb Diagn

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Patients with Liver Cirrhosis (LC) are at high risk of developing bacterial infections. Pathological bacterial translocation has been implicated as an important cause of bacterial infection in patients with LC, and Spontaneous Bacterial Peritonitis (SBP) and bacteremia are common and often fatal bacterial infections in these patients. Moreover, the incidence of hepatorenal syndrome is associated with bacterial infections such as SBP; in addition, the syndrome is often fatal in patients with LC. The frequency of isolation of multidrug-resistant (MDR) organisms in patients with LC and bacterial infections has been reported to be increasing in recent years, and infections caused by MDR organisms appear to be associated with poor prognoses. However, further research is required to better understand bacterial infections in the setting of LC because there remain unresolved problems related to this issue. This review summarizes the frequency, diagnoses, causative organisms, prognoses, and treatment of SBP and bacteremia in patients with LC.

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Section: Causative Organisms Detected In Patients With Lc and Bacteremiamentioning

confidence: 99%

Section: Predictors Of Susceptibility and Prognosis In Patients With ...mentioning

confidence: 99%

Spontaneous Bacterial Peritonitis and Bacteremia in Patients with Liver Cirrhosis

Shizuma

2014

J Med Microb Diagn

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<div>Methicillin-resistant <em>Staphylococcus aureus</em> bacteremia among liver transplant recipients: epidemiology and associated risk factors for morbidity and mortality</div>

Liu¹,

Zhang²,

Wan³

2018

IDR

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Bacteremia due to Staphylococcus aureus, especially methicillin-resistant S. aureus (MRSA), complicates the clinical course of liver transplantation and is associated with high morbidity and mortality. Intravascular catheters had been reported to be the most frequent source of MRSA bacteremia. Among bacteremic liver recipients, 26.3%–100% of S. aureus were MRSA. Previous studies identified pre-transplant and post-transplant acquired S. aureus carriage, greater severity of liver disease, hepatocellular carcinoma and infection with immuno-modulatory viruses as predictors of S. aureus bacteremia in liver recipients. MRSA bacteremia accompanied by pneumonia and abdominal infections was related to mortality. Vancomycin, as well as daptomycin, is a first-line antibiotic for MRSA bacteremia. The purpose of this review is to better understand the characteristics of MRSA bacteremia by summarizing the epidemiology and antimicrobial resistance of S. aureus, the primary source, and related risk factors for morbidity and mortality of MRSA bacteremia. We have also explored the diagnostic, therapeutic and preventive measures for MRSA bacteremia to improve the outcomes of liver recipients.

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Caracterización de pacientes con cirrosis hepática y bacteriemia de un hospital universitario en Medellín, Colombia

Luján-Ramos

Díaz-Ramírez

Martínez-Casas

et al. 2020

Rev Colomb Gastroenterol

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Introducción: la bacteriemia en pacientes cirróticos es frecuente y se asocia con una alta mortalidad y hospitalización prolongada. Este estudio describe las características demográficas, clínicas y de laboratorio en pacientes con cirrosis hepática y bacteriemia en un hospital de cuarto nivel. Métodos: estudio observacional de cohorte retrospectiva. Incluyó pacientes con cirrosis hepática y bacteriemia entre el 1 de enero de 2010 y el 31 de diciembre de 2017 en el Hospital Pablo Tobón Uribe de Medellín, Colombia. Se recogieron variables demográficas, clínicas y de laboratorio. Se estimó la supervivencia durante el tiempo de hospitalización y hasta 30 días desde el diagnóstico de bacteriemia. Resultados: se hallaron 78 pacientes con cirrosis y bacteriemia. La media de edad fue de 65 años, 66,7 % fueron mujeres. Las principales etiologías de la cirrosis fueron: criptogénica (30,8 %) y esteatohepatitis no alcohólica (EHNA; 19,3 %). La principal fuente de infección fue la vía urinaria (24 %), seguida de colangitis (23 %) y la bacteriemia espontánea (19 %). Los bacilos gramnegativos (BGN) representaron la mayoría de los aislamientos (67,9 %). La prevalencia de multidrogorresistentes (MDR) fue de 25,6 % y el uso adecuado de antibiótico empírico fue de 80,8 %. La mortalidad a 30 días fue de 11,5 %. Como mejores predictores de mortalidad se encontraron la puntuación Child-Pugh y Model for End-stage Liver Disease (MELD) al ingreso con área bajo la curva ROC (AUROC) de 0,79 (p = 0,008) y 0.72 (p = 0,042), respectivamente. Conclusiones: los hallazgos permiten conocer las principales características de los pacientes con cirrosis que desarrollan bacteriemia en nuestro medio. Se encontró un número considerable de infecciones MDR. Los pacientes con un grado avanzado de la cirrosis son los que presentan un mayor riesgo de mortalidad.

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Bacteriemia en daño hepático crónico

Abstract: Los autores manifiestan no tener conflictos de interés.

Cited by 5 publications

References 0 publications

Spontaneous Bacterial Peritonitis and Bacteremia in Patients with Liver Cirrhosis

Spontaneous Bacterial Peritonitis and Bacteremia in Patients with Liver Cirrhosis

<div>Methicillin-resistant <em>Staphylococcus aureus</em> bacteremia among liver transplant recipients: epidemiology and associated risk factors for morbidity and mortality</div>

Caracterización de pacientes con cirrosis hepática y bacteriemia de un hospital universitario en Medellín, Colombia

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