Bacteriological evaluation of the non-struvite nephrolithiasis and its association with urinary tract infections

Maier, Adrian; Man, Adrian; Chibelean, C.; Cighir, Teodora; Nemes-Nagy, Enikő; Maier, Ioana Maria; Todea, Carmen; Vida, O.; Martha, Orsolya

doi:10.1515/rrlm-2015-0045

Cited by 4 publications

(7 citation statements)

References 23 publications

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“…The overall prevalence of UTI among patients with urinary stone was 49/300 (16.3%) (95% CI 12–21%). This result is similar to reports by Gutierrez et al 16.2% [ 24 ] and lower than a study done in china 22.0% [ 25 ], Iran 35.5% [ 26 ], Romania 25.8% [ 27 ] and India 45% [ 11 ] among urinary stone patients. However, this result was higher than 7.8% prevalence of UTI reported from Los Angeles, United States [ 28 ].…”

Section: Discussionsupporting

confidence: 89%

“…The resistance to antibiotics such as ampicillin, amoxicillin-clavulanate and Trimethoprim-sulphamethoxzole in this study was 31/33(94%), 18/26(69.23%) and 17(41.5%) respectively which was slightly lower than a report in India ampicillin 96% and amoxicillin-clavulanate 87% [ 30 ]. The result of this study was higher than resistance to Ampicillin 70%, and Amoxicillin-clavulanic acid 30% reported in Romania [ 27 ]. The high rate of resistance might be due to easy access and self-medication, weak adherence of patients to prescribed antimicrobial agents, wider availability of empirical treatment in health care settings [ 12 , 31 , 32 ].…”

Section: Discussioncontrasting

confidence: 64%

“…Most of the isolates identified were susceptible to nitrofurantoin 46/49(94%) and ciprofloxacin 44/49(90%). There were two methicillin resistant S. saprophyticus and one methicillin resistant S. aureus (MRSA) which was nearly similar to a case of methicillin resistant coagulase negative staphylococcus report in Romania [ 27 ].…”

Section: Discussionmentioning

confidence: 70%

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Multiple drug resistance bacterial isolates and associated factors among urinary stone patients at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

et al. 2021

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Background The urinary stone and urinary tract infection (UTI) are invariably associated and are frequent causes of morbidity. Date on burden of UTI among urinary stone patients is lacking in Ethiopia. This study was aimed to assess bacterial profile, antimicrobial susceptibility and associated factors among urinary stone patients at the University of Gondar Comprehensive Specialized Hospital. Methods An institution based cross sectional study was conducted. Basic sociodemographic data were collected using a structured questionnaire. Bacterial identification of uropathogens and drug susceptibility testing were done following standard microbiological techniques. The data were entered and analyzed using SPSS version-23. Bivariate and multivariate logistic regressions were used to identify possible associated risk factors. Results with P value < 0.05 was considered statistically significant. Result A total of 300 urinary stone patients were enrolled. Of these, 153 (51%) were male and 261(87%) were urban residents. The overall prevalence of urinary tract infection was 49 (16.3%) (95% CI 12–21%). A high level of resistance was observed to ampicillin, penicillin and trimethoprim-sulfamethoxazole while majority of isolates were most sensitive to nitrofurantoin and ciprofloxacin. Multi-drug resistant isolates were 16/49 (32.7%), 75% of them being Enterobacteriaceae isolates. More than one-third 9/26 (34.6%) of Gram-negative isolates were Extended Spectrum Beta-Lactamase (ESBL) producing E. coli and K. pneumoniae. Being female, history of urinary tract infection and history of drug use were the independent risk factors. Conclusion Most of the bacterial isolates from urinary stone patients were resistant to ampicillin, penicillin and trimethoprim-sulfamethoxazole. E. coli and K. pneumoniae were the most common extended spectrum beta-lactamase producing isolates. Sex, history of urinary tract infection and previous drug use were found to be risk factors. Routine diagnosis of urinary stone patients for urinary tract infection should be promoted and further researches are encouraged.

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Section: Discussionsupporting

confidence: 89%

Section: Discussioncontrasting

confidence: 64%

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Multiple drug resistance bacterial isolates and associated factors among urinary stone patients at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

et al. 2021

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“…), Actinobacter baumanii, Morganella morganii, and Klebsiella pneumoniae (Table 4). The fact that nonureolytic microorganisms have been found among the most common pathogens recovered from stone samples (for example, certain E. coli strains [107][108][109][110][111][112][113][114] ) suggests that these microorganisms contribute to stone formation.…”

Section: Biologically Induced Stone Formationmentioning

confidence: 99%

“…The presence of other microorganisms in urinary stones, such as fungi (for example, Candida spp. ), although uncommon, has been described 110,114,115 . Indeed, O'Kane et al 115 reported the case study of a woman with a small calculus within the renal pelvis that was completely encapsulated within a fungal bezoar (fungal ball) of Candida dubliniensis; although the mineralogy of the stone was not described in detail, the authors suggested a probable association with uric acid stones (based on imaging; radiolucent on plain X-ray).…”

Section: Biologically Induced Stone Formationmentioning

confidence: 99%

Current insights into the mechanisms and management of infection stones

et al. 2018

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Infection stones are complex aggregates of crystals amalgamated in an organic matrix that are strictly associated with urinary tract infections. The management of patients who form infection stones is challenging owing to the complexity of the calculi and high recurrence rates. The formation of infection stones is a multifactorial process that can be driven by urine chemistry , the urine microenvironment, the presence of modulator substances in urine, associations with bacteria, and the development of biofilms. Despite decades of investigation, the mechanisms of infection stone formation are still poorly understood. A mechanistic understanding of the formation and growth of infection stones-including the role of organics in the stone matrix, microorganisms, and biofilms in stone formation and their effect on stone characteristics-and the medical implications of these insights might be crucial for the development of improved treatments. Tools and approaches used in various disciplines (for example, engineering, chemistry , mineralogy , and microbiology) can be applied to further understand the microorganism-mineral interactions that lead to infection stone formation. Thus, the use of integrated multidisciplinary approaches is imperative to improve the diagnosis, prevention, and treatment of infection stones.

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Exploring the Connection Between Bacterial Biofilms and Renal Calculi: A Comprehensive Review

Mohankumar,

Ganesh,

Shanmugam

2024

J. Pure Appl. Microbiol.

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Bacterial biofilms, structured communities of microorganisms enmeshed in an extracellular matrix, have emerged as significant players in various pathological processes. Renal calculi, commonly known as kidney stones, pose a prevalent medical concern, and recent research has highlighted the potential influence of bacterial biofilms in their formation and persistence. This review explores the development of biofilms on the surface of urinary tract stones and how they create a favorable environment for the colonization of bacteria. This colonization, in turn, can lead to chronic infections, stone enlargement, and recurrent stone formation. This review offers a comprehensive exploration of the dynamic interplay between bacterial biofilms and renal calculi. It emphasizes the role of biofilm-related mechanisms in chronic infections, inflammation, and mineral deposition, underscoring the potential for innovative therapeutic strategies aimed at managing and preventing biofilm-associated renal calculi.

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Bacteriological evaluation of the non-struvite nephrolithiasis and its association with urinary tract infections

Cited by 4 publications

References 23 publications

Multiple drug resistance bacterial isolates and associated factors among urinary stone patients at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

Multiple drug resistance bacterial isolates and associated factors among urinary stone patients at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

Current insights into the mechanisms and management of infection stones

Exploring the Connection Between Bacterial Biofilms and Renal Calculi: A Comprehensive Review

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