Bacteriological profile and sensitivity pattern of urinary tract infection patients in north east part of Bangladesh

Abstract

Background: Urinary tract infection (UTI) is one of the most important causes of bacterial infections across the globe. Increasing antibiotic resistance among urinary pathogens to commonly prescribed drugs has become a therapeutic challenge. Periodic evaluation of antimicrobial activity of different antibiotics is essential as the pattern of antibiotic sensitivity may vary over periods.Methods: This cross-sectional study was undertaken in the Department of Medicine, Sylhet MAG Osmani Medical College, Sylhet from January 2019 to June 2019 among 100 adult patients admitted Medicine indoor Department confirmed as UTI on the basis of symptoms, signs and compatible investigation, urine culture either positive or negative.Results: Out of the total 100 urine samples 60 samples were positive for pathogenic organisms. Escherichia coli was isolated in 41 (68.3%) of the positive samples, followed by Klebsiella sp 13 (21.6%), Pseudomonas sp 3 (5%) Proteus sp 2 (3.3%) staph. Aureus 1 (1.66%). E coli was found to be most sensitive to nitrofurantoin (92.5%), meropenem (92.5%), amikacin (84.6%) and gentamycin (71.8%) and resistant to most commonly used drugs like cefixime (78%), cefuroxime (77.5%), ciprofloxacin (62.5%), ceftriaxone (62.5%).Conclusions: Mainly gram-negative bacilli are found to be responsible for UTI and most frequent isolated bacteria was E-coli. The most sensitive antibiotics were nitrofurantoin, meropenem, and amikacin& gentamycin. Frequently usedantibiotic like cefixime, cefuroxime, cotrimoxazole, ciprofloxacin & ceftriaxone were mostly resistant to E-coli.

Risk factors and antibiogram of human uropathogens in the northern part of Bangladesh: A cross-sectional study

“…In agreement with the previous reports that found women are more likely to experience UTIs than men [32][33][34]35], our findings also show a higher prevalence of UTIs in females (64.40%) than in males (35.60%). There may be more female cases of UTIs than male cases due to factors such as the shorter urethra, the proximity of the urethral meatus to the anus, sexual activity, incontinence, and unhygienic or unsanitary toilet habits.…”

“…The frequency rate was found to be higher in this studied population compared to the previous reports in Bangladesh, in a range between 42.66% and 30.9% [6,[29][30][31]. However, it is also lower than that reported in other studies in Bangladesh, such as 62% [32], 60% [33], and 71% [34]. The research approach, demographics, sample size, and spatial variation may influence these discrepancies.…”