Bacteriology of moderate-to-severe diabetic foot infections in two tertiary hospitals of Iran

Najari, Hamid Reza; Karimian, Tahmine; Parsa, Hossein; QasemiBarqi, Reza; Allami, Abbas

doi:10.1016/j.foot.2019.05.001

Cited by 20 publications

(17 citation statements)

References 20 publications

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“…Providencia spp. (1.4%) and Enterobacter agglomerans (2.9%) were identified from the study participants on the surgical ward of MRRH whereas Escherichia coli and acinobacter are not common but widely prevalent in other clinical settings 23 , 26 . This observed difference in the pattern of prevalence across the various clinical settings could be as a result of divergent geographic distribution of microorganisms and regional differences in antibiotic resistance pattern as well as the level of antibiotic stewardship practices in clinical settings 27 , 28 .…”

Section: Discussionmentioning

confidence: 98%

Chronic wound isolates and their minimum inhibitory concentrations against third generation cephalosporins at a tertiary hospital in Uganda

Tungotyo

Samba

2022

Sci Rep

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Globally, the burden of chronic wound infections is likely to increase due to the rising levels of bacterial resistance to antibiotics. In the United States of America alone, more than 6.5 million chronic wounds with evidence of bacterial infection are diagnosed every year. In addition, the polymicrobial environment in chronic wound infections has been observed from several studies as a risk factor for development of resistance to many antibiotics including the third generation cephalosporins currently used in Mbarara Regional Referral Hospital for treatment of chronic wound infections. Therefore the main objective of this study was to determine the prevalence of chronic wound isolates and their minimum inhibitory concentrations (MIC) against third generation cephalosporins. This study was a cross-sectional descriptive and analytical survey of bacterial isolates from chronic wound infection among 75 study participants admitted in the surgical ward of Mbarara Regional Referral Hospital (MRRH), a tertiary Hospital in Western Uganda. Standard laboratory bacterial culture and identification techniques as well as broth microdilution method were used to isolate, identify pathogens and test for MIC respectively. We found that 69/75 study participants had samples with bacterial growth and the most prevalent pathogens isolated were staphylococcus aureus (40.6%) and Klebsiella spp. (29%). Generally, most isolates were susceptible to cefoperazone + sulbactum 2 g (Sulcef) and ceftriaxone 1 g (Epicephin). The overall prevalence of isolates in chronic wound infection among patients admitted in the surgical ward of MRRH was 92% and the most prevalent isolates were Staphylococcus aureus, Klebsiella species and proteus species respectively. The observed MIC values were higher than the CLSI clinical breakpoint, implying a decreasing trend in susceptibility of chronic wound isolates to third generation cephalosporins.

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Section: Discussionmentioning

confidence: 98%

Chronic wound isolates and their minimum inhibitory concentrations against third generation cephalosporins at a tertiary hospital in Uganda

Tungotyo

Samba

2022

Sci Rep

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“…Several culture methods are therefore used to detect the antibiotic susceptibility and resistance of this bacterium in order to treat infection effectively [ [12] , [13] , [14] ]. However, standardized methods of testing remain short in Iran [ [15] , [16] , [17] ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antibiotic resistance of Helicobacter pylori bacteria obtained from gastric biopsy samples: A cohort study

Azadbakht

Moayyedkazemi

Fard

et al. 2022

Annals of Medicine &Amp; Surgery

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“…More recent studies demonstrated higher rates of ESBL, such as the study by Jouhar et al which found an ESBL prevalence of 25% among 314 enterobacteriaceae isolates (Jouhar et al, 2020). Some studies focusing specifically on E. coli found even higher rates of ESBL, ranging from 43.7% to 77.8% (Al-Joufi et al, 2020;Li et al, 2018;Najari et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Predictors and outcomes of diabetic foot ulcer infection with ESBL-producing bacteria in a large tertiary center

Leibovitch

Cahn

Gellman

et al. 2021

International Journal of Infectious Diseases

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Bacteriology of moderate-to-severe diabetic foot infections in two tertiary hospitals of Iran

Cited by 20 publications

References 20 publications

Chronic wound isolates and their minimum inhibitory concentrations against third generation cephalosporins at a tertiary hospital in Uganda

Chronic wound isolates and their minimum inhibitory concentrations against third generation cephalosporins at a tertiary hospital in Uganda

Evaluation of antibiotic resistance of Helicobacter pylori bacteria obtained from gastric biopsy samples: A cohort study

Predictors and outcomes of diabetic foot ulcer infection with ESBL-producing bacteria in a large tertiary center

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