Bacteriostatic and Bactericidal Activities of Moxifloxacin against
            <i>Coxiella burnetii</i>

Rolain, Jean‐Marc; Maurin, Max; Raoult, Didier

doi:10.1128/aac.45.1.301-302.2001

Cited by 29 publications

(13 citation statements)

References 20 publications

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“…The quinolones have been used with some success [51]. In vitro, gatifloxacin has been shown to be highly effective, and moxifloxacin, gemifloxacin, levofloxacin, pefloxacin, and ofloxacin also have some inhibition of C. burnetii growth [52-56]. Ciprofloxacin has some antimicrobial effect, but not as strong as the other quinolones [52,54].…”

Section: Alternatives For Q Fever Treatmentmentioning

confidence: 99%

Antimicrobial therapies for Q fever

Kersh¹

2013

Expert Review of Anti-infective Therapy

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Summary Q fever is caused by the bacterium Coxiella burnetii and has both acute and chronic forms. The acute disease is a febrile illness often with headache and myalgia that can be self-limiting whereas the chronic disease typically presents as endocarditis and can be life threatening. The normal therapy for the acute disease is a two week course of doxycycline, whereas chronic disease requires 18-24 months of doxycycline in combination with hydroxychloroquine. Alternative treatments are used for pregnant women, young children, and those who cannot tolerate doxycycline. Doxycycline resistance is rare but has been reported. Co-trimoxazole is a currently recommended alternative treatment, but quinolones, rifampin, and newer macrolides may also provide some benefit.

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Section: Alternatives For Q Fever Treatmentmentioning

confidence: 99%

Antimicrobial therapies for Q fever

Kersh¹

2013

Expert Review of Anti-infective Therapy

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“…At the concentrations used (for tigecycline, 0.03 g/ml to 8 g/ml, and for the rest of the antibiotics, 0.25 g/ml to 16 g/ml), the solvents were nontoxic to normal or infected Vero cells. The bacteriostatic and bactericidal effects of antibiotics against C. burnetii were tested by a shell vial assay (1,4,5,6,9,13,16,21). For this purpose, Vero cell monolayers cultured in shell vials were infected with 10-fold serial dilutions of a C. burnetii inoculum to determine the inoculum dilution that resulted in 50% infected Vero cells after 6 days of incubation.…”

mentioning

confidence: 99%

Bacteriostatic and Bactericidal Activities of Tigecycline against Coxiella burnetii and Comparison with Those of Six Other Antibiotics

Spyridaki

Psaroulaki

Vranakis

et al. 2009

Antimicrob Agents Chemother

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The present article is a study of the in vitro susceptibility of eight Greek Coxiella burnetii isolates, derived from patients with acute Q fever, and two reference strains of Coxiella burnetii to tigecycline. The bacteriostatic activity of tigecycline was compared with those of six other antibiotics using a shell vial assay. The MICs of the examined antibiotics were as follows: tigecycline ranged from 0.25 to 0.5 g/ml; doxycycline, trovafloxacin, and ofloxacin ranged from 1 to 2 g/ml; linezolid and clarithromycin ranged from 2 to 4 g/ml; and ciprofloxacin ranged from 4 to 8 g/ml. Tigecycline was effective in inhibiting the infection of Vero cells by C. burnetii. No bactericidal activity was observed against C. burnetii at 4 g/ml.

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“…This regimen is effective clinically, but there is a heterogeneity in the rapidity of the biological response to treatment depending on the levels of doxycycline in serum (17). Few C. burnetii strains were tested for antibiotic susceptibility in vitro with MICs of doxycycline ranging from 1 to 4 g/ml (6,7,15,18,19). The shell vial technique was the most widely used method (7,15).…”

mentioning

confidence: 99%

Correlation between Ratio of Serum Doxycycline Concentration to MIC and Rapid Decline of Antibody Levels during Treatment of Q Fever Endocarditis

Rolain

Boulos

Mallet

et al. 2005

Antimicrob Agents Chemother

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Endocarditis is the major clinical manifestation of chronic Q fever. Although doxycycline along with hydroxychloroquine remains the mainstay of medical therapy for Q fever endocarditis, there are wide variations in the rapidity of the patient's decline of antibody levels during such therapy. We undertook a retrospective examination of whether there was any correlation between the ratio of serum concentration to MIC of doxycycline and response to treatment in patients with Q fever endocarditis. Included herein are 16 patients from whom Coxiella burnetii was isolated from cardiac valve materials. Serology and measurement of doxycycline and hydroxychloroquine serum levels were performed and recorded after 1 year of treatment. The MIC of doxycycline for C. burnetii isolates was determined using the shell vial assay in a real-time quantitative PCR assay. At the completion of a yearlong therapy with doxycycline-hydroxychloroquine, all those that showed a low decline of antibody levels (n ‫؍‬ 6) (i.e., <2-fold decrease in antibody titer to phase I C. burnetii antigen) had a ratio of serum doxycycline concentration to MIC between 0.5 and 1. In contrast, those having a ratio of >1 showed a rapid decline of phase I antibody levels (n ‫؍‬ 9; P < 0.05). The only patient who died had a serum doxycycline-to-MIC ratio of <0.5, and the isolate of C. burnetii cultured from this patient was resistant to doxycycline (MIC ‫؍‬ 8 g/ml). The ratio of serum doxycycline concentration to MIC should be monitored during the course of therapy in patients with Q fever endocarditis.

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Bacteriostatic and Bactericidal Activities of Moxifloxacin against Coxiella burnetii

Abstract: The in vitro activity of moxifloxacin against Coxiella burnetii was compared to those of pefloxacin, ofloxacin, and doxycycline. MICs of moxifloxacin ranged from 0.5 to 1 g/ml for the Nine Mile, Priscilla, and Q212 strains. Moxifloxacin was not bactericidal against C. burnetii at 4 g/ml.

Cited by 29 publications

References 20 publications

Antimicrobial therapies for Q fever

Antimicrobial therapies for Q fever

Bacteriostatic and Bactericidal Activities of Tigecycline against Coxiella burnetii and Comparison with Those of Six Other Antibiotics

Correlation between Ratio of Serum Doxycycline Concentration to MIC and Rapid Decline of Antibody Levels during Treatment of Q Fever Endocarditis

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