Bafoudiosbulbins A, and B, two anti-salmonellal clerodane diterpenoids from Dioscorea bulbifera L. var sativa

Teponno, Rémy Bertrand; Tapondjou, Azefack Léon; Gatsing, Donatien; Djoukeng, Jules Désiré; Abou-Mansour, Eliane; Tabacchi, Raffaele; Tane, Pierre; Stoekli-Evans, Helen; David, Laurent

doi:10.1016/j.phytochem.2006.06.019

Cited by 90 publications

(70 citation statements)

References 19 publications

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“…52 D. bulbifera tubers are known to contain various bioactive compounds, including flavonoids, terpenoids, phenanthrenes, amino acids, protein, and glycosides. [53][54][55][56][57][58][59] It is speculated that the alcohol groups are oxidized to carbonyl groups in the course of reduction, which supports the suggestion that polyol groups are primarily responsible for the bioreduction process. Thus, the water-soluble fractions of D. bulbifera played key roles in the bioreduction of the precursors and evolution of shape in the nanoparticles.…”

Section: Discussionmentioning

confidence: 69%

Synthesis of silver nanoparticles using Dioscorea bulbifera tuber extract and evaluation of its synergistic potential in combination with antimicrobial agents

Ghosh¹,

Patil²,

Ahire³

et al. 2012

IJN

210

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Background Development of an environmentally benign process for the synthesis of silver nanomaterials is an important aspect of current nanotechnology research. Among the 600 species of the genus Dioscorea, Dioscorea bulbifera has profound therapeutic applications due to its unique phytochemistry. In this paper, we report on the rapid synthesis of silver nanoparticles by reduction of aqueous Ag + ions using D. bulbifera tuber extract. Methods and results Phytochemical analysis revealed that D. bulbifera tuber extract is rich in flavonoid, phenolics, reducing sugars, starch, diosgenin, ascorbic acid, and citric acid. The biosynthesis process was quite fast, and silver nanoparticles were formed within 5 hours. Ultraviolet-visible absorption spectroscopy, transmission electron microscopy, high-resolution transmission electron microscopy, energy dispersive spectroscopy, and x-ray diffraction confirmed reduction of the Ag + ions. Varied morphology of the bioreduced silver nanoparticles included spheres, triangles, and hexagons. Optimization studies revealed that the maximum rate of synthesis could be achieved with 0.7 mM AgNO 3 solution at 50°C in 5 hours. The resulting silver nanoparticles were found to possess potent antibacterial activity against both Gram-negative and Gram-positive bacteria. Beta-lactam (piperacillin) and macrolide (eryth-romycin) antibiotics showed a 3.6-fold and 3-fold increase, respectively, in combination with silver nanoparticles selectively against multidrug-resistant Acinetobacter baumannii. Notable synergy was seen between silver nanoparticles and chloramphenicol or vancomycin against Pseudomonas aeruginosa , and was supported by a 4.9-fold and 4.2-fold increase in zone diameter, respectively. Similarly, we found a maximum 11.8-fold increase in zone diameter of streptomycin when combined with silver nanoparticles against E. coli , providing strong evidence for the synergistic action of a combination of antibiotics and silver nanoparticles. Conclusion This is the first report on the synthesis of silver nanoparticles using D. bulbifera tuber extract followed by an estimation of its synergistic potential for enhancement of the antibacterial activity of broad spectrum antimicrobial agents.

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Section: Discussionmentioning

confidence: 69%

Synthesis of silver nanoparticles using Dioscorea bulbifera tuber extract and evaluation of its synergistic potential in combination with antimicrobial agents

Ghosh¹,

Patil²,

Ahire³

et al. 2012

IJN

210

View full text Add to dashboard Cite

show abstract

“…It is already known that silver nanoparticles in the aqueous solution are defined by an absorption spectrum in the range of 400 to 450 nm (Zargar et al 2011). It was also suggested that frequency and width of the surface plasmon resonance (SPR) absorption are correlated with the morphology and size of the nanoparticles (Teponno et al 2006). The morphological characterization was achieved through scanning electron microscopy ( Figure 3).…”

Section: Synthesis Of Silver Nanoparticlesmentioning

confidence: 99%

Impact of biosynthesized silver nanoparticles on protein and carbohydrate contents in seeds of Pisum sativum L.

Mehmood¹,

Murtaza

2017

Crop Breed. Appl. Biotechnol.

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“…It is also used in the treatment of carbuncles, lung abscesses, breast lumps, and goiter (Gao et al, 2003). In addition, DB displays a range of pharmacological properties, including antitumor (Grynberg et al, 1999), antifeedant (Cifuente et al, 2002), antiinflammation (Demetzos et al, 2001), and antisalmonellal activities (Teponno et al, 2006). DB and related remedies are used for the treatment of thyroid gland diseases and varieties of tumors (Tang, 1995;Rasikari et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Cytochrome P450–Mediated Metabolic Activation of Diosbulbin B

Lin

Peng

et al. 2014

Drug Metab Dispos

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Diosbulbin B (DIOB), a furan-containing diterpenoid lactone, is the most abundant component of Dioscorea bulbifera L. (DB), a traditional Chinese medicine herb. Administration of purified DIOB or DB extracts has been reported to cause liver injury in animals. The mechanisms of DIOB-induced hepatotoxicity remain unknown. The major objective of this study was to identify reactive metabolites of DIOB. A DIOB-derived cis-enedial was trapped by N-acetyl lysine (NAL) and glutathione (GSH) or N-acetyl cysteine (NAC) in rat and human liver microsomal incubation systems after exposure to DIOB. Four metabolites (M1-M4) associated with GSH were detected by liquid chromatography coupled to tandem mass spectrometry. Apparently, M1 was derived from both NAL and GSH. M2 and M3 resulted from the reaction of GSH without the involvement of NAL. Two molecules of GSH participated in the formation of M4. M2 and M3 were also detected in bile and urine of rats given DIOB. M5, a DIOB-derived NAC/NAL conjugate, was detected in microsomal incubations with DIOB fortified with NAC and NAL as trapping agents. Biomimetic M1-M5 were prepared by oxidation of DIOB with Oxone for metabolite identification. Microsomal incubation study demonstrated that ketoconazole inhibited the production of the enedial in a concentration-dependent manner, and CYP3A4 was found to be the enzyme responsible for the metabolic activation of DIOB. The metabolism study facilitates the understanding of the role of bioactivation of DIOB in its hepatotoxicity.

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Bafoudiosbulbins A, and B, two anti-salmonellal clerodane diterpenoids from Dioscorea bulbifera L. var sativa

Cited by 90 publications

References 19 publications

Synthesis of silver nanoparticles using Dioscorea bulbifera tuber extract and evaluation of its synergistic potential in combination with antimicrobial agents

Synthesis of silver nanoparticles using Dioscorea bulbifera tuber extract and evaluation of its synergistic potential in combination with antimicrobial agents

Impact of biosynthesized silver nanoparticles on protein and carbohydrate contents in seeds of Pisum sativum L.

Cytochrome P450–Mediated Metabolic Activation of Diosbulbin B

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