2015
DOI: 10.1038/cddis.2015.53
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BAG3 regulates formation of the SNARE complex and insulin secretion

Abstract: Insulin release in response to glucose stimulation requires exocytosis of insulin-containing granules. Glucose stimulation of beta cells leads to focal adhesion kinase (FAK) phosphorylation, which acts on the Rho family proteins (Rho, Rac and Cdc42) that direct F-actin remodeling. This process requires docking and fusion of secretory vesicles to the release sites at the plasma membrane and is a complex mechanism that is mediated by SNAREs. This transiently disrupts the F-actin barrier and allows the redistribu… Show more

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Cited by 22 publications
(29 citation statements)
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“…Insulin secretion by exocytosis of its storage granules is a complex mechanism that involves numerous proteins and is regulated by multiple pathways to finely control circulating glucose levels. Previously published data reported a moderate positivity of BAG3 in the islets of Langerhans of pancreatic adenocarcinoma patients, whereas normal pancreatic ducts and pancreatic acinar cells exhibited no BAG3 expression (Iorio et al, ). Normally, in response to elevated blood‐glucose levels, pancreatic‐islet β‐cells release insulin in order to maintain glucose homeostasis.…”
Section: Introductionmentioning
confidence: 92%
“…Insulin secretion by exocytosis of its storage granules is a complex mechanism that involves numerous proteins and is regulated by multiple pathways to finely control circulating glucose levels. Previously published data reported a moderate positivity of BAG3 in the islets of Langerhans of pancreatic adenocarcinoma patients, whereas normal pancreatic ducts and pancreatic acinar cells exhibited no BAG3 expression (Iorio et al, ). Normally, in response to elevated blood‐glucose levels, pancreatic‐islet β‐cells release insulin in order to maintain glucose homeostasis.…”
Section: Introductionmentioning
confidence: 92%
“…2, event 5). These events destabilize F-actin to facilitate insulin release (52,104,105). The Ca 2ϩ -activated actin-severing gelsolin is also involved in insulin secretion (118), forming complexes with syntaxin 4, which are disrupted by glucose stimulation, freeing the t-SNARE to promote exocytosis and gelsolin to remodel F-actin (57) (Fig.…”
Section: Letting the Skeleton Out Of The Closetmentioning
confidence: 99%
“… 17 A recent study showed that following glucose stimulation, BIS was phosphorylated by focal adhesion kinase, which led to F-actin remodeling. 18 …”
Section: Introductionmentioning
confidence: 99%