Bagaza Virus in Wild Birds, Portugal, 2021

Queirós, João; Barros, Sílvia C.; Sánchez-Cano, Alberto; Henriques, A.; Fagulha, Teresa; Santos, Fábio A. Abade dos; Duarte, Margarida; Fontoura-Gonçalves, Catarina; Gonçalves, David; Rodrigues, Marisa; Cabrera, Teresa Cardona; Mera, Isabel G. Fernández de; Gortázar, Christian; Höfle, Úrsula; Alves, Paulo C.

doi:10.3201/eid2807.212408

Cited by 11 publications

(5 citation statements)

References 10 publications

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“…Another favivirus, namely, the Bagaza virus (BAGV), could be the origin for the ELISA seropositivity detected in the 28 animals from Hérault. BAGV has been known since 1966 in central Africa and was recently involved in fatal outbreaks among wild birds in Spain and Portugal [44]. Te virus showed a strong cross-reactivity with both WNV and USUV on ELISA tests [25].…”

Section: Resultsmentioning

confidence: 99%

Evidence of Antibodies against the West Nile Virus and the Usutu Virus in Dogs and Horses from the Southeast of France

Laidoudi

Durand

Watier-Grillot

et al. 2023

Transboundary and Emerging Diseases

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Every year, the world faces vector-borne diseases including arboviral (arthropod-borne viral) diseases caused by several, possibly fatal flaviviruses. The way they spread is related to a complex episystem involving several elements including vector abundance, animal carriers, and the flavivirus itself, which makes the disease difficult to manage. Here, we serologically screened 556 animals (358 dogs and 198 horses) using ELISA and a serum neutralisation test (SNT) for the anti-IgG antibodies directed against the West Nile (WNV) and Usutu (USUV) viruses. The animals investigated were split into two groups according to their exposure to the risk linked to the abundance of mosquitoes and migratory birds as well as the geographical distribution of arbovirus cases (458 animals from areas exposed to risk and 98 not exposed to risk). Overall, 25/310 dogs (8.1%) and 2/148 horses (1.3%) tested positive for SNT WNV and/or USUV in geographically exposed areas. Animals in unexposed areas were all negative. The geographical distribution of WNV seroprevalence in dogs was the same as the distribution of reported autochthonous human cases. Interestingly, a non-negligible seroprevalence caused by an as yet unidentified flavivirus other than WNV, USUV, or tick-borne encephalitis virus (TBEV) was detected in 18.6% (28/150) and 3.7% (4/106) of the investigated dogs and horses from the Hérault department, in the southeast of France, respectively. These data highlight the role of outdoor dogs as suitable sentinels for the evidence of WNV and USUV circulation in each area. In addition, the serological detection of an as yet unidentified flavivirus circulating in the Hérault department deserves greater attention, as this may constitute a serious threat to public and animal health.

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Section: Resultsmentioning

confidence: 99%

Evidence of Antibodies against the West Nile Virus and the Usutu Virus in Dogs and Horses from the Southeast of France

Laidoudi

Durand

Watier-Grillot

et al. 2023

Transboundary and Emerging Diseases

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“…7 and no. 8 in Queirós et al, 2022 [ 19 ]) revealed the presence of BAGV, and one of these samples (no. 7, which showed the lowest Ct value) was used for further molecular characterization and virus isolation.…”

Section: Methodsmentioning

confidence: 94%

“…In 2021, BAGV was detected for the first time in resident wild birds (red-legged partridges and corn bunting) in southern Portugal [ 19 ], and the whole genome sequencing and genetic analyses (including phylogenetic/phylogeographic reconstructions) were undertaken to characterize this BAGV strain. While BAGV had never been detected in Portugal before, not surprisingly, phylogenetic inference and genetic distance calculations based on the analysis of aligned polyprotein coding sequence of 108 public flavivirus ORFs demonstrated the close relationships between BAGV PT/2021 and the BAGV strain from the 2010 outbreak in Spain.…”

Section: Discussionmentioning

confidence: 99%

“…In October 2021, the carcasses of two red-legged partridges, found dead in a hunting ground in Serpa, in southern Portugal, were received at the National Reference Laboratory (NRL) of Portugal, INIAV I.P., and submitted for necropsy and molecular diagnosis [ 19 ]. Several tissue samples from both specimens (including, brain, heart, kidney, spleen, and intestine) were screened for the presence of BAGV by RT-qPCR targeting the NS5 coding region [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

“…Despite sharing land borders with Spain, where the disease was reported in 2010 and 2019, no evidence of BAGV circulation had been reported in Portugal prior to 2021 [ 19 ]. In this report, we carried out the genetic characterization and phylogenetic analysis of the full-length polyprotein genomic sequence of BAGV responsible for the BAGV Portugal 2021 outbreak.…”

Section: Introductionmentioning

confidence: 99%

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Genome Characterization and Spaciotemporal Dispersal Analysis of Bagaza Virus Detected in Portugal, 2021

et al. 2023

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In September 2021, Bagaza virus (BAGV), a member of the Ntaya group from the Flavivirus genus, was detected for the first time in Portugal, in the heart and the brain of a red-legged partridge found dead in a hunting ground in Serpa (Alentejo region; southern Portugal). Here we report the genomic characterization of the full-length sequence of the BAGV detected (BAGV/PT/2021), including phylogenetic reconstructions and spaciotemporal analyses. Phylogenies inferred from nucleotide sequence alignments, complemented with the analysis of amino acid alignments, indicated that the BAGV strain from Portugal is closely related to BAGV strains previously detected in Spain, suggesting a common ancestor that seems to have arrived in the Iberia Peninsula in the late 1990s to early 2000s. In addition, our findings support previous observations that BAGV and Israel turkey meningoencephalitis virus (ITV) belong to the same viral species.

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Virus de connaissance récente et actualisation

Fleury

2023

Virus Émergents Et Ré-Émergents

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Bagaza Virus in Wild Birds, Portugal, 2021

Cited by 11 publications

References 10 publications

Evidence of Antibodies against the West Nile Virus and the Usutu Virus in Dogs and Horses from the Southeast of France

Evidence of Antibodies against the West Nile Virus and the Usutu Virus in Dogs and Horses from the Southeast of France

Genome Characterization and Spaciotemporal Dispersal Analysis of Bagaza Virus Detected in Portugal, 2021

Virus de connaissance récente et actualisation

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