Baicalein, a natural product, selectively activating AMPKα2 and ameliorates metabolic disorder in diet-induced mice

Pu, Peiyu; Wang, Xinan; Salim, Mohamed; Zhu, Lihua; Wang, Lang; Chen, kvo-Jv; Xiao, Jinfeng; Deng, Wei; Shi, Hongwei; Jiang, Hong; Li, Hongliang

doi:10.1016/j.mce.2012.06.002

Cited by 104 publications

(53 citation statements)

References 32 publications

(32 reference statements)

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“…Besides, baicalein was reported to have antihyperglycemic effects through the improvement of islet β-cell survival and mass [8]. Moreover, the supplementation of baicalein (400 mg/kg/d) in in mice fed with high fat diet for 29 weeks ameliorated insulin resistance and hyperglycemia through activation of AMPK signaling pathways in liver [12]. In the present study, treatment with baicalein in obese mice significantly decreased AUC and HOMA-IR values compared to the obese controls.…”

Section: Discussionsupporting

confidence: 56%

“…Recent studies reported that baicalein might play an anti-obesity role [9,12]. The supplementation of baicalein (400 mg/kg/d) in mice fed with high fat diet for 29 weeks ameliorated the severity of obesity and hyperlipidemia [12].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, it was also found that treatment with baicalein to diabetes obviously stimulated the pPI3K and pAkt and inhibited the level of pGSK3β [11]. Additionally, the previous work verified that baicalein has been shown to increase insulin sensitivity in livers of diet-induced obese mice by blocking of AMPK-mediated MAPKs pathway [12]. Nevertheless, there are few reports about the effect of baicalein on insulin sensitivity and GLUT4 function of transporting glucose into adipocytes.…”

Section: Introductionmentioning

confidence: 98%

“…A few studies reported that baicalein exhibits the anti-obesity, anti-diabetic, antioxidant and anti-inflammatory activities [8][9][10][11][12]. Baicalein was reported to have antihyperglycemic effects through the improvement of islet β-cell survival and mass [8].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Baicalein on GLUT4 Translocation in Adipocytes of Diet-Induced Obese Mice

Wen

Fang

et al. 2018

Cell Physiol Biochem

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Background/Aims: Although baicalein has been shown to increase insulin sensitivity in liver of mice, there is no literature available about the effect of baicalein on glucose transporter 4 (GLUT4) translocation from intracellular membrane pools to plasma membranes in adipocytes of diet-induced obese mice. Methods: In the present study, the obese model was induced in mice fed a high fat diet (20% carbohydrates, 21% protein and 59% fat) for 16 weeks. The diet-induced obese mice were given 20mg/kg baicalein intraperitoneally (i.p.) once a day for 21 days. The plasma insulin was measured by enzyme-linked immunosorbent assay. Fasting blood glucose and insulin resistance indexes were measured by glucose tolerance test (GTT). The expression levels of PGC-1α, UCP1, GLUT4, PPARγ, pP38MAPK, pERK and pAKT in adipocytes were determined by quantitative real-time polymerase chain reaction and western blotting. Results: The present findings showed that administration of baicalein decreased pP38MAPK, pERK and PPARγ levels, but enhanced pAKT, PGC-1α and UCP1 contents as well as GLUT4 expression in adipocytes, and reversed high fat diet-induced glucose intolerance, hyperglycemia and insulin resistance in diet-induced obese mice. Moreover, baicalein treatment increased GLUT4 concentration in plasma membranes of adipocytes, i.e. baicalein may prevent insulin resistance through the GLUT4 translocation from intracellular membrane compartments to plasma membranes in adipocytes. Conclusion: These results suggest that baicalein is a powerful and promising agent for treatment of obesity and insulin resistance via Akt/GLUT4 pathway.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of Baicalein on GLUT4 Translocation in Adipocytes of Diet-Induced Obese Mice

Wen

Fang

et al. 2018

Cell Physiol Biochem

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show abstract

“…It has been reported that baicalein acts as an α-glucosidase inhibitor [14], and possesses the following therapeutic properties; anticancer [15,16], osteosarcoma treatment [17], apoptosis induction in human myeloma cells [18], neuroprotective [19], and protection from metabolic syndrome [20]. This review highlights the recent studies which establish the cardioprotective features of baicalein and examines the underlying mechanisms involved in this property.…”

Section: Introductionmentioning

confidence: 96%

Cardioprotective Potential of Baicalein: A Short Review of In Vitro and In Vivo Studies

Chen¹,

Ravich²,

Senthilkumar³

et al. 2013

Pharm Anal Acta

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Nutraceutical‐BasedPharmacological Intervention in the Management of Liver Diseases

Shah¹,

Mudassar²

2018

Nutraceuticals and Natural Product Derivatives

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Baicalein, a natural product, selectively activating AMPKα2 and ameliorates metabolic disorder in diet-induced mice

Cited by 104 publications

References 32 publications

Effect of Baicalein on GLUT4 Translocation in Adipocytes of Diet-Induced Obese Mice

Effect of Baicalein on GLUT4 Translocation in Adipocytes of Diet-Induced Obese Mice

Cardioprotective Potential of Baicalein: A Short Review of In Vitro and In Vivo Studies

Nutraceutical‐BasedPharmacological Intervention in the Management of Liver Diseases

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