Baicalein and luteolin inhibit ischemia/reperfusion-induced ferroptosis in rat cardiomyocytes

Wang, I-Chieh; Lin, Jianhong; Lee, Wen-Sen; Liu, Chin‐Hung; Lin, Ting-Yuan; Yang, Kun‐Ta

doi:10.1016/j.ijcard.2022.12.018

Cited by 28 publications

(7 citation statements)

References 75 publications

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“…Resveratrol also showed potential to attenuate ischemia/reperfusion injury through anti-ferroptotic activity [ 110 , 111 , 112 ]. Some other compounds that displayed promising results for treatment of ischemia/reperfusion injuries were rhein [ 113 ], vitexin [ 114 ], naringenin [ 115 ], loureirin C [ 116 ], caffeic acid [ 117 ], baicalein [ 118 , 119 ], luteolin [ 119 ], kaempferol [ 120 ], and others. The predominant mechanism underlying this phenomenon involves the upregulation of GPX4 and SLC7A11 expression, along with the modulation of iron metabolism.…”

Section: Resultsmentioning

confidence: 99%

Beyond Mortality: Exploring the Influence of Plant Phenolics on Modulating Ferroptosis—A Systematic Review

Živanović,

Lesjak,

Simin

et al. 2024

Antioxidants

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Ferroptosis is a recently discovered type of programmed cell death that is mechanistically different from other types of programmed cell death such as apoptosis, necroptosis, and autophagy. It is characterized by the accumulation of intracellular iron, overproduction of reactive oxygen species, depletion of glutathione, and extensive lipid peroxidation of lipids in the cell membrane. It was discovered that ferroptosis is interconnected with many diseases, such as neurodegenerative diseases, ischemia/reperfusion injury, cancer, and chronic kidney disease. Polyphenols, plant secondary metabolites known for many bioactivities, are being extensively researched in the context of their influence on ferroptosis which resulted in a great number of publications showing the need for a systematic review. In this review, an extensive literature search was performed. Databases (Scopus, Web of Science, PubMed, ScienceDirect, Springer) were searched in the time span from 2017 to November 2023, using the keyword “ferroptosis” alone and in combination with “flavonoid”, “phenolic acid”, “stilbene”, “coumarin”, “anthraquinone”, and “chalcone”; after the selection of studies, we had 311 papers and 143 phenolic compounds. In total, 53 compounds showed the ability to induce ferroptosis, and 110 compounds were able to inhibit ferroptosis, and out of those compounds, 20 showed both abilities depending on the model system. The most researched compounds are shikonin, curcumin, quercetin, resveratrol, and baicalin. The most common modes of action are in the modulation of the Nrf2/GPX4 and Nrf2/HO-1 axis and the modulation of iron metabolism.

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Section: Resultsmentioning

confidence: 99%

Beyond Mortality: Exploring the Influence of Plant Phenolics on Modulating Ferroptosis—A Systematic Review

Živanović,

Lesjak,

Simin

et al. 2024

Antioxidants

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“…Numerous studies have demonstrated the antiferroptotic capabilities of baicalein [41][42][43][44][45]. In rat cardiomyocytes, baicalein countered ferroptosis triggered by ischemia/reperfusion by limiting the build-up of reactive oxygen species and malondialdehyde [42].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Traditional Chinese and Japanese herbal medicines have long used baicalein, a natural flavonoid found in the roots of Scutellaria baicalensis and Scutellaria lateriflora, to treat bacterial and viral illnesses [40]. Furthermore, baicalein exhibits antioxidative effects by scavenging reactive oxygen species, inhibiting lipid peroxidation, and attenuating oxidative damage associated with ferroptosis [41][42][43][44][45].…”

Section: Introductionmentioning

confidence: 99%

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Translational Potential of Baicalein in Mitigating RSL3-Induced Ferroptosis in Fibroblasts: Implications for Therapeutic Interventions

Kuo,

Rau,

et al. 2024

Int. J. Med. Sci.

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Background: Ferroptosis is an iron-driven cell-death mechanism that plays a central role in various diseases. Recent studies have suggested that baicalein inhibits ferroptosis, making it a promising therapeutic candidate. Materials and Methods: Fibroblast cultures were treated with different agents to determine the effects of baicalein on ferroptosis. Ferroptosis-related gene expression, lipid peroxidation, and post-treatment cellular structural changes were measured using real-time quantitative polymerase chain reaction, C11-BODIPY dye, and transmission electron microscopy, respectively. Results: Baicalein significantly inhibited rat sarcoma virus selective lethal 3-induced ferroptosis in fibroblasts. Moreover, in baicalein-treated groups, reduced ferroptosis-related gene expression, decreased lipid peroxidation, and maintained cell structure was observed when compared with those of the controls. Discussion: The ability of baicalein to counteract RSL3-induced ferroptosis underscores its potential protective effects, especially in diseases characterized by oxidative stress and iron overload in fibroblasts. Conclusion: Baicalein may serve as a potent therapeutic agent against conditions in which ferroptosis is harmful. The compound's efficacy in halting RSL3-triggered ferroptosis in fibroblasts paves the way for further in vivo experiments and clinical trials.

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“…In addition, SBG is now listed officially in Chinese Pharmacopoeia (2015), European Pharmacopoeia (EP 9.0), and British Pharmacopoeia (BP 2018) ( Xiang et al, 2022 ; Jang et al, 2023 ). Baicalein (chemical structure, Figure 1 ), one of the predominant flavonoids in SBG, has anti-inflammatory, and anti-cardiovascular and cerebrovascular effects ( Guo et al, 2021 ; Dinda et al, 2023 ; Wang et al, 2023 ). Typically, the smaller the degree of unsaturation, the more stable the substance will be.…”

Section: Introductionmentioning

confidence: 99%

Mechanism of baicalein in treatment of castration-resistant prostate cancer based on network pharmacology and cell experiments

Dou,

Cui,

Zhou

et al. 2024

Front. Pharmacol.

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ObjectiveBaicalein, one of the most abundant flavonoids found in Chinese herb Scutellaria baicalensis Georgi, exhibits pharmacological activities against various cancers. However, the precise pharmacological mechanism of baicalein in treating castration-resistant prostate cancer (CRPC) remains elusive. This study aimed to elucidate the potential mechanism of baicalein against CRPC through a combination of network pharmacology and experimental approaches, thereby providing new avenues for research in CRPC treatment.MethodsThe pharmacological and molecular properties of baicalein were obtained using the TCMSP database. Baicalein-related targets were collected from multiple sources including SwissTargetPrediction, PharmMapper and CTD. Targets related to CRPC were acquired from DisGeNET, GeneCards, and CTD. The protein-protein interaction (PPI) was analyzed using STRING 11.5, and Cytoscape 3.7.2 software was utilized to explore the core targets of baicalein on CRPC. GO and KEGG pathway enrichment analysis were performed using DAVID database. Cell experiments were carried out to confirm the validity of the targets.ResultsA total of 131 potential targets of baicalein for the treatment of CRPC were obtained. Among them, TP53, AKT1, ALB, CASP3, and HSP90AA1, etc., were recognized as core targets by Cytoscape 3.7.2. GO function enrichment analysis yielded 926 entries, including 703 biological process (BP) terms, 84 cellular component (CC) terms and 139 molecular function (MF) terms. The KEGG pathway enrichment analysis unveiled 159 signaling pathways, mainly involved in Pathways in cancer, prostate cancer, AGE-RAGE signaling pathway in diabetic complications, TP53 signaling pathway, and PI3K-Akt signaling pathway, etc. Cell experiments confirmed that baicalein may inhibit the proliferation of CRPC cells and induce cell cycle arrest in the G1 phase. This effect could be associated with the TP53/CDK2/cyclin E1 pathway. In addition, the results of CETSA suggest that baicalein may directly bind to TP53.ConclusionBased on network pharmacology analysis and cell experiments, we have predicted and validated the potential targets and related pathways of baicalein for CRPC treatment. This comprehensive approach provides a scientific basis for elucidating the molecular mechanism underlying the action of baicalein in CRPC treatment. Furthermore, these findings offer valuable insights and serve as a reference for the research and development of novel anti-CRPC drugs.

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Baicalein and luteolin inhibit ischemia/reperfusion-induced ferroptosis in rat cardiomyocytes

Cited by 28 publications

References 75 publications

Beyond Mortality: Exploring the Influence of Plant Phenolics on Modulating Ferroptosis—A Systematic Review

Beyond Mortality: Exploring the Influence of Plant Phenolics on Modulating Ferroptosis—A Systematic Review

Translational Potential of Baicalein in Mitigating RSL3-Induced Ferroptosis in Fibroblasts: Implications for Therapeutic Interventions

Mechanism of baicalein in treatment of castration-resistant prostate cancer based on network pharmacology and cell experiments

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