Baicalin Ameliorates Corticosterone-Induced Depression by Promoting Neurodevelopment of Hippocampal via mTOR/GSK3β Pathway

Wang, Zhe; Cheng, Yating; Lu, Ye; Sun, Guoqiang; Lin, Pei

doi:10.1007/s11655-022-3590-z

Cited by 7 publications

(1 citation statement)

References 48 publications

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“…Topical application of baicalin (100 mg/mL) in a mouse model of pressure ulcers accelerates wound healing through the downregulation of pro-inflammatory cytokines (IL-6 and IL-1β) along with the upregulation of the anti-inflammatory cytokine IL-10 and several growth factors (VEGF, FGF-2, PDGF-β, and CTGF) [101]. Furthermore, baicalin ameliorates corticosterone-induced depression symptoms by promoting the neurodevelopment of the hippocampal via mTOR/GSK3 β pathway [102]. There are also some pieces of evidence that baicalin exerts anti-depressant effects by increasing the expression of genes encoding enzymes involved in the glycolytic pathway and TCA cycle, thus improving brain energy and function [103].…”

Section: In Vivo Studiesmentioning

confidence: 99%

Baicalin—Current Trends in Detection Methods and Health-Promoting Properties

et al. 2023

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Baicalin (7-D-glucuronic acid-5,6-dihydroxyflavone) belongs to natural flavonoids extracted from the roots of Scutellaria baicalensis, the plant used in traditional Chinese medicine. It has been proven that baicalin has various pharmacological activities, such as antioxidant, anti-inflammatory, anticancer, antibacterial, and anti-apoptotic ones. However, it is essential not only to determine the medical usefulness of baicalin, but also to find and develop the most effective methods for its extraction and detection. Therefore, the aim of this review was to summarize the current methods of detection and identification of baicalin and to present the medical applications of baicalin and the underlying mechanisms of its action. Based on the review of the latest literature, it can be concluded that liquid chromatography alone or together with mass spectrometry is the most commonly used method for the determination of baicalin. Recently, also new electrochemical methods have been established, e.g., biosensors with fluorescence, which have better detection limits, sensitivity, and selectivity.

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Section: In Vivo Studiesmentioning

confidence: 99%