Baicalin and berberine ultradeformable vesicles as potential adjuvant in vitiligo therapy

Mir-Palomo, Silvia; Nácher, Amparo; Busó, M.A. Ofelia Vila; Caddeo, Carla; Manca, Maria Letizia; Manconi, Maria; Dı́ez-Sales, Octavio

doi:10.1016/j.colsurfb.2018.12.055

Cited by 20 publications

(6 citation statements)

References 19 publications

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“…It could further observe the cellular structures of the specimens in vivo owing to the images with a spatial resolution of 0.5-1.0 mm in the lateral and 3-5 mm in the axial dimension. 13,14) Histological Examination In order to detect the tissues from the perilesional skin of the vitiligo lesions and healthy skin by using microscopic. Tissue samples were taken out and formalin-fixed.…”

Section: Methodsmentioning

confidence: 99%

The Therapeutic Effects of Baicalin on Vitiligo Mice

Zhu

Zhong

Peng

et al. 2019

Biological & Pharmaceutical Bulletin

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Vitiligo is a commom disease of skin. Its pathogenesis is complex, resulting in the incapacity to find a targeted cure. Baicalin, which is isolated from Scutellariae radix, has been known to exhibit a number of pharmacological effects on autoimmune diseases. In this study, we explored the effects of Baicalin on the recovery of vitiligo stimulated by monophenylketone in mice. We observed that Baicalin slowed down the progression of depigmentation, decreased the incidence of depigmentation, and reduced the area of depigmentation. Moreover, reflectance confocal microscopy (RCM) shown that Baicalin increased the epidermal melanocytes in depigmented skin. Baicalin decreased CD8 T cell infiltration in mice skin, and decreased the expression of CXCL10 and CXCR3. Baicalin significantly decreased the levels of serum cytokine (interleukin [IL]-6, tumor necrosis factor [TNF]-α, interferon-γ [IFN-γ], and IL-13). Collectively, these data suggest that Baicalin play an important role in the occurrence and development of vitiligo.

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Section: Methodsmentioning

confidence: 99%

The Therapeutic Effects of Baicalin on Vitiligo Mice

Zhu

Zhong

Peng

et al. 2019

Biological & Pharmaceutical Bulletin

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“…About 0.5-1% population of the world is suffered from vitiligo; to treat the symptoms of vitiligo, a research group formulated the baicalin- and berberine-loaded ultra-deformable vesicles. TFS due to their deformable nature carried these molecules into deeper layers where they showed eminent photoprotective and antioxidant effects (96). Naringin is a strong antioxidant agent, having amazing radical oxygen species hunting potential.…”

Section: Peptides and Proteinsmentioning

confidence: 99%

Transfersomes: a Revolutionary Nanosystem for Efficient Transdermal Drug Delivery

et al. 2021

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Transdermal delivery system has gained significance in drug delivery owing to its advantages over the conventional delivery systems. However, the barriers of stratum corneum along with skin irritation are its major limitations. Various physical and chemical techniques have been employed to alleviate these impediments. Among all these, transfersomes have shown potential for overcoming the associated limitations and successfully delivering therapeutic agents into systemic circulation. These amphipathic vesicles are composed of phospholipids and edge activators. Along with providing elasticity, edge activator also affects the vesicular size and entrapment efficiency of transfersomes. The mechanism behind the enhanced permeation of transfersomes through the skin involves their deformability and osmotic gradient across the application site. Permeation enhancers can further enhance their permeability. Biocompatibility; capacity for carrying hydrophilic, lipophilic as well as high molecular weight therapeutics; deformability; lesser toxicity; enhanced permeability; and scalability along with potential for surface modification, active targeting, and controlled release render them ideal designs for efficient drug delivery. The current review provides a brief account of the discovery, advantages, composition, synthesis, comparison with other cutaneous nano-drug delivery systems, applications, and recent developments in this area.

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“…One group 60 prepared baicalin and berberine samples that were co-loaded with ultradeformable vesicles and demonstrated their potential as adjuvants for the treatment of vitiligo. Baicalin and berberine were selected as curative agents due to their antioxidant, anti-inflammatory and proliferative effects.…”

Section: Nano-drug Delivery System In the Treatment Of Vitiligomentioning

confidence: 99%

“…During the transformation of melanocytes into melanoma cells, endothelin B receptor expression gradually increases. 112 One group reported that Endothelin-1 (ET-1) promotes melanin synthesis and the formation of dendrites in normal human epidermal melanocytes. 113 Similarly, a seven-transmembrane receptor on keratinocytes termed protease-activated receptor-2 (PAR-2) plays a central role in the transportation of melanosomes.…”

Section: Principles Of Nano-drug Delivery Systems Designed For Vitilimentioning

confidence: 99%

<p>Recent Progress and Future Directions: The Nano-Drug Delivery System for the Treatment of Vitiligo</p>

Sun

Lou

et al. 2020

IJN

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Vitiligo is a depigmentation disease that seriously affects the physical health, mental health and quality of life of a patient. Therapeutic aim at control immunoreaction by relieving oxidative stress. Unfortunately, the cuticle barrier function and lack of specific accumulation lead to unsatisfactory therapeutic outcomes and side effects. The introduction and innovation of nanotechnology offers inspiration and clues for the development of new strategies to treat vitiligo. However, not many studies have been done to interrogate how nanotechnology can be used for vitiligo treatment. In this review, we summarize and analyze recent studies involving nano-drug delivery systems for the treatment of vitiligo, with a special emphasis on liposomes, niosomes, nanohydrogel and nanoparticles. These studies made significant progress by either increasing drug loading efficiency or enhancing penetration. Based on these studies, there are three proposed principles for topical nano-drug delivery systems treatment of vitiligo including the promotion of transdermal penetration, enhancement of drug retention and facilitation of melanin regeneration. The presentation of these ideas may provide inspirations for the future development of topical drug delivery systems that will conquer vitiligo.

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Baicalin and berberine ultradeformable vesicles as potential adjuvant in vitiligo therapy

Cited by 20 publications

References 19 publications

The Therapeutic Effects of Baicalin on Vitiligo Mice

The Therapeutic Effects of Baicalin on Vitiligo Mice

Transfersomes: a Revolutionary Nanosystem for Efficient Transdermal Drug Delivery

<p>Recent Progress and Future Directions: The Nano-Drug Delivery System for the Treatment of Vitiligo</p>

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