Baicalin attenuates chronic unpredictable mild stress-induced hippocampal neuronal apoptosis through regulating SIRT1/PARP1 signaling pathway

Ma, Zhongxuan; Feng, Dingding; Wei, Rui; Wang, Zhiqing

doi:10.1016/j.bbr.2023.114299

Cited by 5 publications

(2 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…23 GAS has been proven to possess potent antioxidant and antiinflammatory effects, which has also been reported to have the depression-ameliorating function. 24 Research has found that GAS can improve depression-like behaviors in rats by upregulating the brain-derived neurotrophic factor (BDNF) expression in their hippocampal astrocytes. 25 Nevertheless, its exact action target has rarely been reported so far.…”

Section: Discussionmentioning

confidence: 99%

“…Expressions of multiple inflammatory factors can promote the activation of Caspase‐3/9 signaling to induce nerve cell damage 23 . GAS has been proven to possess potent antioxidant and anti‐inflammatory effects, which has also been reported to have the depression‐ameliorating function 24 . Research has found that GAS can improve depression‐like behaviors in rats by upregulating the brain‐derived neurotrophic factor (BDNF) expression in their hippocampal astrocytes 25 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Gastrodin improves nerve cell injury and behaviors of depressed mice through Caspase‐3‐mediated apoptosis

Pei,

Shen,

et al. 2023

CNS Neurosci Ther

View full text Add to dashboard Cite

AimWe investigated the effects and target of gastrodin (GAS) for treating depression through network pharmacology combined with experimentation.MethodsThe therapeutic target and signal of GAS for depression were analyzed by network pharmacology. Depression in mice was mimicked with a chronic unpredictable mouse stress (CUMS) model. Through open field, elevated plus maze, forced swimming, and tail suspension tests, the effects of GAS on the CUMS mice behaviors were examined, and the levels of neurotransmitters were detected. The histopathological changes were assayed by H&E and IHC staining, and the protein expressions were detected by Western blotting. Small molecule‐protein docking and molecular dynamics experiments were conducted to simulate the binding mode between GAS and Caspase‐3.ResultsNetwork pharmacological analysis revealed that Caspase‐3 was the action target of GAS. GAS could improve depression‐like behaviors in CUMS mice, elevate their neurotransmitter levels, ameliorate their nerve cell injury, and inhibit their Caspase‐3 expression. After knocking out Caspase‐3, the effects of GAS were inhibited. Molecular dynamics simulation and small molecule‐protein docking found that GAS bound to Caspase‐3 at SER25, inhibiting the maturation and activation of Caspase‐3.ConclusionWe find that GAS can act as a Caspase‐3 inhibitor, which improves depression‐like behaviors and nerve cell injury in CUMS mice by inhibiting Caspase‐3‐mediated apoptosis.

show abstract

Section: Discussionmentioning

confidence: 99%