Baikal seal virus

Likhoshway, Ye. V.; Ma, Grachev; Vp, Kumarev; YuV, Solodun; Oa, Goldberg; Белых, О. И.; Nagieva, F. G.; Vg, Nikulina; Bs, Kolesnik

doi:10.1038/339266a0

Cited by 21 publications

(10 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unexpectedly, however, the H gene of two CDV strains, 179/04 and 48/05, were more tightly related (up to 98.4% aa) to CDVs of the Arctic lineage, that includes the canine strain GR88 detected in Northern Greenland in 1988 (Blixenkrone-Møller et al, 1992), the phocine strain PDV-2, identified in 1988 from a Siberian seal (Phoca siberica) of Lake Baikal (Visser et al, 1990) and the canine strain, isolate Liud, detected in China in the mid 1990s. The initial description of Arctic viruses dates back to the late 1980s, when morbillivirusrelated epizootics were observed in seals in Northern Europe and Siberia (Likhoshway et al, 1989;Osterhaus and Vedder, 1988;Titenko et al, 1990;Visser et al, 1990). Subsequent genetic analysis demonstrated that the 1987 and 1988 epizootics were epidemiologically distinct, as they were caused by a phocine distemper virus, PDV-1 and by a CDV-like strain, PDV-2, respectively.…”

Section: Discussionmentioning

confidence: 99%

Heterogeneity within the hemagglutinin genes of canine distemper virus (CDV) strains detected in Italy

Martella

Cirone

Elia

et al. 2006

Veterinary Microbiology

142

123

View full text Add to dashboard Cite

Canine distemper virus (CDV) is a highly contagious viral pathogen causing lethal disease in dogs and other mammalians. A high degree of genetic variation is found between recent CDV strains and the old CDV isolates used in the vaccines and such genetic variation is regarded as a possible cause of the increasing number of CDV-related diseases in dogs. The H gene shows the greatest extent of genetic variation that allows for distinction of various lineages, according to a geographical pattern of distribution and irrespective of the species of identification. In the present study, hemagglutinin (H) genes obtained from field strains detected from clinical specimens of Italian dogs were analyzed genetically. Phylogenetic analysis revealed that a homogeneous group of CDV strains is widespread in Italian dogs, all which are included into the European lineage. Unexpectedly, strains 179/04 and 48/05 clustered along with CDVs of the Arctic lineage, the highest identity being to strain GR88 (98.0 and 98.4%aa, respectively). The full-length sequence of a red fox CDV strain, 207/00 was also determined and analyzed. The H protein of the fox CDV strain was unrelated to strains within the major European lineage. These results suggest that at least three different CDV lineages are present in Italy.

show abstract

Section: Discussionmentioning

confidence: 99%

Heterogeneity within the hemagglutinin genes of canine distemper virus (CDV) strains detected in Italy

Martella

Cirone

Elia

et al. 2006

Veterinary Microbiology

142

123

View full text Add to dashboard Cite

show abstract

“…The virus epizootic which occurred in seals in Northern Europe during the summer and autumn of 1988 was caused by a morbillivirus closely related to, but distinct from, CDV (Osterhaus and Vedder, 1988;Mahy et al, 1988;Haas et al, 1991). A similar disease was seen in seals in Lake Baikal, Siberia, in December 1987, sometime earlier than the European epizootic Likhoshway et al, 1989;Osterhaus et al, 1989a, b;Titer&o et al, 1990). There was no obvious epidemiological link between the outbreak in marine seals in Europe and that in freshwater seals in Lake Baikal several thousand kilometers distant.…”

Section: Introductionmentioning

confidence: 96%

Characterisation of morbilliviruses isolated from Lake Baikal seals (Phoca sibirica)

Mamaev

Деникина

Беликов

et al. 1995

Veterinary Microbiology

View full text Add to dashboard Cite

Sequence analysis of the haemagglutinin protein (H) gene of the morbillivirus (PDV-2) isolated from a Siberian seal (Phoca sibirica) during the 1987/1988 epizootic in Lake Baikal revealed that it was most closely related to two recent isolates of canine distemper virus (CDV) from Germany and different from CDV vaccines currently in use in that region. The virus continued to circulate in seals in Lake Baikal after the 1987/1988 epizootic since sera collected from culled seals in the spring of 1992 were positive in morbillivirus ELISA tests, reacting most strongly with the CDV antigen.

show abstract

“…3,4,5 Besides the two outbreaks of PDV among harbour seals, CDV has caused disease outbreaks among Baikal seals ( Phoca sibirica ) in the Siberian Lake Baikal and among Caspian seals ( Phoca caspica ) in the Caspian Sea. 6,7,8,9 …”

Section: Introductionmentioning

confidence: 99%

Prevalence of phocine distemper virus specific antibodies: bracing for the next seal epizootic in north-western Europe

Bodewes

Morick²,

Bildt

et al. 2013

Emerging Microbes & Infections

View full text Add to dashboard Cite

In 1988 and 2002, two major phocine distemper virus (PDV) outbreaks occurred in harbour seals (Phoca vitulina) in north-western European coastal waters, causing the death of tens of thousands seals. Here we investigated whether PDV is still circulating among seals of the Dutch coastal waters and whether seals have protective serum-antibodies against PDV. Therefore seal serum samples, collected from 2002 to 2012, were tested for the presence of PDV-neutralizing antibodies. Antibodies were detected in most seals in 2002 and 2003 while after 2003 antibodies were detected only in seals less than two month-old and adult seals that probably had survived the 2002 PDV-epizootic. We estimated the current proportion of seals with antibodies against PDV at 11%. These findings suggest that at present the vast majority of seals are not immune to PDV infection. PDV re-introduction in this area may cause a major epizootic with infection of >80% and mass-mortality of >50% of the population.

show abstract

Baikal seal virus

Cited by 21 publications

References 7 publications

Heterogeneity within the hemagglutinin genes of canine distemper virus (CDV) strains detected in Italy

Heterogeneity within the hemagglutinin genes of canine distemper virus (CDV) strains detected in Italy

Characterisation of morbilliviruses isolated from Lake Baikal seals (Phoca sibirica)

Prevalence of phocine distemper virus specific antibodies: bracing for the next seal epizootic in north-western Europe

Contact Info

Product

Resources

About