Bal kamrai deformáció cardialis könnyűlánc-amyloidosisban és hypereosinophilia-szindrómában. Eredmények a MAGYAR-Path Tanulmányból

Kormányos, Árpád; Domsik, Péter; Kalapos, Anita; Marton, Imelda; Földeák, Dóra; Modok, Szabolcs; Gyenes, Nándor; Borbényi, Zita; Nemes, Attila

doi:10.1556/650.2020.31584

Cited by 3 publications

(6 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, the effects of different risk factors and aging could also play a role with haemodynamic effects of the aorta and its stiffened walls [19]. Moreover, the above mentioned functional abnormalities of the LV and LA could also have effects on each other resulting in MA dilation and functional impairment, as well [7,9,10]. Due to left heart abnormalities, changes may be present in the right heart as well despite absence of any cardiovascular symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…Aortic stiffness is increased in HES, but little is known about HES-related remodeling of heart chambers before the development of Loeffler endocarditis [ 7 , 8 , 9 , 10 , 19 ]. The novel echocardiographic technique, 3D echocardiography is a non-invasive method, and it seems to be optimal to quantify changes of atria and ventricles respecting the cardiac cycle [ 12 , 13 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…Cardiac impairment was seen in some cases, early phases were characterized by eosinophilic infiltration, then there was a thrombotic stage, followed by a final fibrotic stage [ 3 , 4 , 5 , 6 ]. Novel cardiovascular imaging techniques enabled the detection of subclinical cardiac abnormalities in HES cases being in necrotic phase including dilation and functional impairment of both atria [ 7 , 8 ] and reduction of left ventricular (LV) rotational and deformation mechanics [ 9 , 10 ]. Based on our results, it can be hypothesized that the abnormalities of the ventricular and atrial volumetric and deformation parameters lead to compensatory changes in the mitral (MA) and/or tricuspid annulus (TA), in their size and function.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mitral and Tricuspid Annular Abnormalities in Hypereosinophilic Syndrome—Insights from the Three-Dimensional Speckle-Tracking Echocardiographic MAGYAR-Path Study

Nemes¹,

Kormányos²,

Rácz³

et al. 2023

Rev. Cardiovasc. Med.

Self Cite

View full text Add to dashboard Cite

Background: Hypereosinophilic syndrome (HES) is a peripheral eosinophilia characterized by elevated absolute eosinophil cell count (>1.500 cells/µL) and consequent tissue and end-organ damage. Our aim was to evaluate the mitral annular (MA) and/or tricuspid annular (TA) parameters of patients with HES and to determine whether there are any changes in these parameters compared to healthy individuals. Methods: 17 patients with HES were involved in our study, 2 cases were excluded due to suboptimal image quality (mean age of the evaluated patients: 61.7 ± 11.2 years, 10 males). Their data were compared with those of 24 healthy subjects (mean age: 55.2 ± 7.9 years, 12 males) in the control group. Complete echocardiographic examinations were performed including two-dimensional (2D) Doppler echocardiography and three-dimensional echocardiography (3DE) to assess the MA and the TA. Results: Comparing the echocardiographic parameters of the HES patients with those of the healthy volunteers, the following changes were seen: the interventricular septum was significantly thickened in HES patients, no other significant changes were detected between the examined patient groups. End-diastolic and end-systolic MA diameters, areas and perimeters were increased and MA fractional area change and MA fractional shortening were decreased in HES patients. From TA morphological parameters, only end-diastolic TA area and end-systolic TA perimeter were significantly increased in HES patients. Functional TA parameters showed no significant alterations in the HES group. In patients with HES, no correlations could be detected between 2D and 3D echocardiographic data with the examined laboratory findings. Conclusions: The extent of the dilation of the MA is more pronounced than that of the TA in HES. MA functional impairment is present in HES.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mitral and Tricuspid Annular Abnormalities in Hypereosinophilic Syndrome—Insights from the Three-Dimensional Speckle-Tracking Echocardiographic MAGYAR-Path Study

Nemes¹,

Kormányos²,

Rácz³

et al. 2023

Rev. Cardiovasc. Med.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The aim of our study was to evaluate the clinical value of 3DSTE in certain disorders like HES. The results from the MAGYAR-Path study presented several abnormalities in the valvular and myocardial mechanics in HES [ 16 , 17 , 18 , 19 , 20 , 21 ].…”

Section: Cardiovascular Imaging and Magyar-path Studymentioning

confidence: 99%

“…In a 2DSTE study, global LV-CS and global LV-RS were similar in normal controls and in patients with HES, but the global LV-LS of the normal controls was significantly higher than that of the patients with HES, and a global LV-LS ≤ 17% was the best predictor of LV endocardial dysfunction [ 31 ]. Results from the MAGYAR-Path study, in a comparison with matched healthy subjects, no LV dilation but a reduced 3DSTE-derived global LV-LS could be detected in patients with HES, localized to the basal regions [ 16 ]. Moreover, reduced LV apical rotation and twist were present in patients with HES, being mostly in the early necrotic phase.…”

Section: The Left Heart and The Aortamentioning

confidence: 99%

Cardiac Mechanics and Valvular and Vascular Abnormalities in Hypereosinophilic Syndrome

Nemes

2024

JCM

View full text Add to dashboard Cite

Hypereosinophilic syndrome (HES) is considered to be a rare myeloproliferative disease that is characterized by persistent eosinophilia with associated multiple-organ damage. The heart is often involved in HES, representing a major cause of morbidity and mortality. HES is a heterogeneous group of disorders; the majority of the cases are idiopathic. Summarizing the findings regarding myocardial, valvular, and vascular abnormalities in a series of patients with HES, most studies found normal left ventricular (LV) volumes with reduced LV global longitudinal strain and LV apical rotation and twist in HES cases, accompanied by increased left atrial (LA) volumes and stroke volumes, reduced peak LA circumferential strain (representing systolic abnormalities), and mitral annular dilation and functional deterioration. Regarding the right heart, preserved right ventricular volumes and functional properties, increased right atrial volumes, mild RA functional abnormalities, and dilated tricuspid annular dimensions without functional impairment could be seen in these studies. Aortic and pulmonary valves showed no specific disease-related alterations. Vascular abnormalities included increased aortic stiffness without dilation of the aorta and pulmonary hypertension in some cases. These results suggest disease-specific but relatively mild myocardial, valvular, and vascular abnormalities in HES. The present review aimed to summarize the available clinical data about cardiac mechanics and valvular and vascular abnormalities in a series of patients with HES.

show abstract

The tricuspid annulus in amyloidosis with cardiac involvement: Detailed analysis from the three-dimensional speckle tracking echocardiographic MAGYAR-Path Study

Nemes¹,

Rácz²,

Kormányos³

et al. 2022

IJC Heart & Vasculature

Self Cite

View full text Add to dashboard Cite

Bal kamrai deformáció cardialis könnyűlánc-amyloidosisban és hypereosinophilia-szindrómában. Eredmények a MAGYAR-Path Tanulmányból

Cited by 3 publications

References 27 publications

Mitral and Tricuspid Annular Abnormalities in Hypereosinophilic Syndrome—Insights from the Three-Dimensional Speckle-Tracking Echocardiographic MAGYAR-Path Study

Mitral and Tricuspid Annular Abnormalities in Hypereosinophilic Syndrome—Insights from the Three-Dimensional Speckle-Tracking Echocardiographic MAGYAR-Path Study

Cardiac Mechanics and Valvular and Vascular Abnormalities in Hypereosinophilic Syndrome

The tricuspid annulus in amyloidosis with cardiac involvement: Detailed analysis from the three-dimensional speckle tracking echocardiographic MAGYAR-Path Study

Contact Info

Product

Resources

About