Balance, Excretion and Tissue Distribution of Vanadium in Rats after Short-Term Ingestion

Adachi, Atsuko; Ogawa, K.; Tsushi, Yukiko; Nagao, Naoko; Okano, Toshio

doi:10.1248/jhs.46.59

Cited by 11 publications

(7 citation statements)

References 2 publications

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“…The results are shown in Table 1 and are expressed as the relative amount (%) [ 48 V]vanadium activity per These results are in accordance with previous reports [16,18,23,24,25,26,27,28]. In some reports, high vanadium concentrations were found in the stomach and lungs, owing to a different administration route (respectively orally and intratracheally) [22,29].…”

Section: Distribution Of [ 48 V]vanadium In Tissues and Bloodsupporting

confidence: 89%

Fractionation of vanadium complexes in serum, packed cells and tissues of Wistar rats by means of gel filtration and anion-exchange chromatography

et al. 2002

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Male Wistar rats were intraperitoneally injected with [(48)V]vanadium tracer to (1) investigate the distribution of vanadium over different tissues and (2) study the distribution of vanadium over the proteins and peptides in serum, packed cells and homogenates of tissues by means of liquid chromatography experiments (size exclusion, ion exchange). Target organs were primarily kidney, bone, spleen and liver. In serum we found that vanadium was mainly bound to transferrin; however, a small amount was also bound to albumin. Besides these two complexes, a significant part of vanadium occurred as readily exchangeable ("free") vanadium. In packed cells, vanadium is mainly bound to hemoglobin and to two abundant low molecular mass complexes. The chromatograms of tissues (kidney, liver, testes, spleen and lung) show similar high molecular mass complexes (vanadium co-elutes with ferritin, transferrin and hemoglobin). Between the low molecular mass complexes there are similar peaks for spleen, testes and kidneys on the one hand, and liver and lung on the other hand, albeit the differences are small. In the case of lung, there is an additional low molecular mass peak.

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Section: Distribution Of [ 48 V]vanadium In Tissues and Bloodsupporting

confidence: 89%

Fractionation of vanadium complexes in serum, packed cells and tissues of Wistar rats by means of gel filtration and anion-exchange chromatography

et al. 2002

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“…Weight change in the liver of male rats was observed at the lowest exposure concentration for both compounds; however this weight change was not observed in any other sex/species. Studies in the literature suggest that vanadyl sulfate and sodium metavanadate may have effects on metabolic pathways, however no histopathological evidence of toxicity was observed in multiple studies with exposures up to one year at comparable doses to those used in the present studies [1], [31], [6]. Kidney weight changes were less consistent than liver changes in the male rats, however these changes may indicate potential toxicity.…”

Section: Discussioncontrasting

confidence: 62%

“…Therefore, some understanding of total body burden may be used as a surrogate for determination of oxidation state in tissues and can help explain differences in toxicity. Studies in the literature have assessed the oral bioavailability of various vanadium compounds in tissues and urine, under different conditions, and reported a wide range of values from less than 1%, up to 16% [1], [3], [23]. By testing tetravalent and pentavalent vanadium under nearly identical conditions, the present and future NTP studies can begin to explore similarities or differences in biological response between the different oxidation states.…”

Section: Discussionmentioning

confidence: 99%

14-day toxicity studies of tetravalent and pentavalent vanadium compounds in Harlan Sprague Dawley rats and B6C3F1/N mice via drinking water exposure

et al. 2016

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BackgroundThe National Toxicology Program (NTP) performed short-term toxicity studies of tetra- and pentavalent vanadium compounds, vanadyl sulfate and sodium metavanadate, respectively. Due to widespread human exposure and a lack of chronic toxicity data, there is concern for human health following oral exposure to soluble vanadium compounds.ObjectivesTo compare the potency and toxicological profile of vanadyl sulfate and sodium metavanadate using a short-term in vivo toxicity assay.MethodsAdult male and female Harlan Sprague Dawley (HSD) rats and B6C3F1/N mice, 5 per group, were exposed to vanadyl sulfate or sodium metavanadate, via drinking water, at concentrations of 0, 125, 250, 500, 1000 or 2000 mg/L for 14 days. Water consumption, body weights and clinical observations were recorded throughout the study; organ weights were collected at study termination.ResultsLower water consumption, up to −80% at 2000 mg/L, was observed at most exposure concentrations for animals exposed to either vanadyl sulfate or sodium metavanadate and was accompanied by decreased body weights at the highest concentrations for both compounds. Animals in the 1000 and 2000 mg/L sodium metavanadate groups were removed early due to overt toxicity. Thinness was observed in high-dose animals exposed to either compound, while lethargy and abnormal gait were only observed in vanadate-exposed animals.ConclusionsBased on clinical observations and overt toxicity, sodium metavanadate appears to be more toxic than vanadyl sulfate. Differential toxicity cannot be explained by differences in total vanadium intake, based on water consumption, and may be due to differences in disposition or mechanism of toxicity.

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“…Vanadium absorption among the control animals presented values that were clearly higher than those described in previous publications [43,44]. The higher absorption of vanadium found in our study could be related to the type of vanadium complex supplied and/or the different methods used to determine the presence of this element in the faeces.…”

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confidence: 76%

Bioavailability, tissue distribution and hypoglycaemic effect of vanadium in magnesium-deficient rats

Sánchez

Torres²,

Bermúdez-Peña³

et al. 2011

Magnesium Research

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Vanadium is an element whose role as a micronutrient and hypoglycaemic drug has yet to be fully clarified. The present study was undertaken to investigate the bioavailability and tissue distribution of vanadium and its interactions with magnesium in healthy and in magnesium-deficient rats, in order to determine its role as a micronutrient and antidiabetic agent. Four groups were used: control (456.4 mg magnesium and 0.06 mg vanadium/kg food); control treated with 1mg vanadium/day; magnesium-deficient (164.4 mg magnesium/kg food and 0.06 mg vanadium/kg food); and magnesium-deficient treated with 1 mg vanadium/day. The vanadium was supplied in the drinking water as bis(maltolato)oxovanadium (IV). The experiment had a duration of five weeks. We measured vanadium and magnesium in excreta, serum, skeletal muscle, kidney, liver, adipose tissue and femur. Fasting glucose, insulin and total antioxidant status (TAS) in serum were studied. The vanadium treatment applied to the control rats reduced the absorption, retention, serum level and femur content of magnesium. Magnesium deficiency increased the retention and serum level of vanadium, the content of vanadium in the kidney, liver and femur (organs where magnesium had been depleted), serum glycaemia and insulin, and reduced TAS. V treatment given to magnesium-deficient rats corrected magnesium content in muscle, kidney and liver and levels of serum glucose, insulin and TAS. In conclusion, our results show interactions between magnesium and vanadium in the digestive and renal systems. Treatment with vanadium to magnesiumdeficient rats corrected many of the alterations that had been generated by the magnesium deficiency.

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Balance, Excretion and Tissue Distribution of Vanadium in Rats after Short-Term Ingestion

Cited by 11 publications

References 2 publications

Fractionation of vanadium complexes in serum, packed cells and tissues of Wistar rats by means of gel filtration and anion-exchange chromatography

Fractionation of vanadium complexes in serum, packed cells and tissues of Wistar rats by means of gel filtration and anion-exchange chromatography

14-day toxicity studies of tetravalent and pentavalent vanadium compounds in Harlan Sprague Dawley rats and B6C3F1/N mice via drinking water exposure

Bioavailability, tissue distribution and hypoglycaemic effect of vanadium in magnesium-deficient rats

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