Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors

Neumann, Inga D.; Landgraf, Rainer

doi:10.1016/j.tins.2012.08.004

Cited by 814 publications

(691 citation statements)

References 130 publications

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“…The short term memory and learning processes were examined by object discrimination, as we did not wanted to confound our results with potential social alterations (Neumann and Landgraf, 2012). We confirmed the positive effect of centrally released AVP in short-term recognition memory.…”

Section: Discussionsupporting

confidence: 63%

Restoration of peripheral V2 receptor vasopressin signaling fails to correct behavioral changes in Brattleboro rats

Balázsfi

Pintér

Klausz

et al. 2015

Psychoneuroendocrinology

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Short title:Stress-related behavior in Brattleboro rat after DDAVP treatment You created this PDF from an application that is not licensed to print to novaPDF printer (http://www.novapdf.com) Balázsfi et al. 2Highlights  The effect of AVP on affective and memory symptoms is due to its central role  DDAVP treatment compensated the peripheral effects of congenital AVP absence  DDAVP did not significantly alter the behavior of KO animals in the paradigms tested  AVP signaling in the medial amygdala contributes to the behavioral effect measured in FS AbstractBeside its hormonal function in salt and water homeostasis, vasopressin -released into distinct brain areas -plays a crucial role in stress-related behavior resulting in the enhancement of an anxious/depressive-like state.We aimed to investigate whether correction of the peripheral symptoms of congenital absence of AVP also corrects the behavioral alterations in AVP-deficient Brattleboro rats. Wild type (WT) and vasopressin-deficient (KO) male Brattleboro rats were tested.Half of the KO animals were treated by desmopressin (V2-receptor agonist) via osmotic minipump (subcutaneous) to eliminate the peripheral symptoms of vasopressin-deficiency. Anxiety was studied by elevated plus maze (EPM), defensive withdrawal (DW) and marble burying (MB) tests, while depressive-like changes were monitored in forced swimming (FS) and anhedonia by sucrose preference test. Cell activity was examined in septum and amygdala by c-Fos immunohistochemistry after 10min FS.

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Section: Discussionsupporting

confidence: 63%

Restoration of peripheral V2 receptor vasopressin signaling fails to correct behavioral changes in Brattleboro rats

Balázsfi

Pintér

Klausz

et al. 2015

Psychoneuroendocrinology

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“…These results are consistent with differences in vasopressin protein levels in the PVN of these species 25 . Moreover, while vasopressin is known to promote anxiety in rodents 26 , our genetic analyses of anxiety-related behaviour in the same animals argue that effects of vasopressin on parental nest-building behaviour in Peromyscus are not mediated simply through changes in anxiety (Extended Data Fig. 9; Supplementary Discussion).…”

Section: Introductionmentioning

confidence: 77%

The genetic basis of parental care evolution in monogamous mice

Bendesky

Kwon

Lassance

et al. 2017

Nature

233

202

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Summary Parental care is essential for the survival of mammals, yet the mechanisms underlying its evolution remain largely unknown. Here we show that two sister species of mice, Peromyscus polionotus and P. maniculatus, have large and heritable differences in parental behaviour. Using quantitative genetics, we identify 12 genomic regions that affect parental care, eight of which have sex-specific effects, suggesting that parental care can evolve independently in males and females. Furthermore, some regions affect parental care broadly, whereas others affect specific behaviours, such as nest building. Of the genes linked to differences in nest-building behaviour, vasopressin is differentially expressed in the hypothalamus of the two species, with increased levels associated with less nest building. Using pharmacology in Peromyscus and chemogenetics in Mus, we show that vasopressin inhibits nest building but not other parental behaviours. Together, our results indicate that variation in an ancient neuropeptide contributes to interspecific differences in parental care.

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“…First, it remains a matter of discussion whether peripherally measured oxytocin is indicative for central release patterns and activities within the brain [39]. Some studies suggest that certain stimuli lead to coordinated release of central and peripheral oxytocin, whereas other studies indicate that certain stimuli change central levels while leaving peripheral levels unchanged [40]. In addition, the reliability of oxytocin measurement is still under debate [39], and issues have been raised regarding the importance of preanalytical procedures [41].…”

Section: Discussionmentioning

confidence: 99%