The recent rapprochement among China, Iran and Russia reveals the emergence of a new, unexpected, regional strategic triangle with the potential to balance the United States’ dominant position. By focusing on the evolution of this strategic triangle in the post-Cold War period, this article investigates the driving forces that bring the three states together, namely the US power and unilateralism as materialised in NATO’s eastward expansion, the sanctions on Russia after the annexation of Crimea and the war in Ukraine, the sanctions against Iran, the US trade war with China and the hostile US posture during the coronavirus disease-2019 pandemic. Drawing on soft balancing theory, this article provides an empirical assessment of China–Iran– Russia strategies in countering the US power. Thus, this article aims to fill a gap in the existing literature by investigating this triangular relationship and its balancing potential under the analytic construct of a strategic triangle. Finally, the analysis demonstrates that the three states have employed soft balancing mechanisms, primarily economic strengthening and entangling diplomacy in international institutions. At the same time, territorial denial was sought on various occasions due to the regional importance of this triangular relationship. In conclusion, the article also offers insights into potential hard-balancing behaviour in the long run.