Balanitis associated with FOLFIRI chemotherapy

Micevic, Goran; Perkins, Sara; Zubek, Amanda

doi:10.1016/j.jdcr.2017.09.001

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…Our literature review found a few cases of capecitabine-associated PPE presenting with painful erythema with swelling and ulceration of the scrotum and penis (Table 1) [1-3]. Its active form, 5-FU, has also rarely shown skin toxicity with penile or scrotal involvement [10-11]. Tyrosine kinase inhibitors and liposomal anthracyclines are other drugs that rarely cause blistering or ulcerating lesions on the penis or scrotum with concurrent skin toxicity in the hands and feet [12-13].…”

Section: Discussionmentioning

confidence: 99%

Palmar-plantar Erythrodysesthesia with Genital Involvement Secondary to Capecitabine Chemoradiotherapy: A Case Report

Hu¹,

Corkum²,

Perera³

2018

Cureus

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Palmar-plantar erythrodysesthesia (PPE) is a common dermatologic adverse reaction secondary to capecitabine use, but the skin toxicity rarely involves the genitals. We describe a case of PPE with scrotal and penile involvement secondary to capecitabine chemotherapy concurrent with radiotherapy. The patient presented with pain and erythema involving the penis and scrotum during the fifth week of neoadjuvant chemoradiotherapy with capecitabine for T3c N2b M0 low rectal adenocarcinoma. The onset and severity of symptoms in the genitals were loosely associated with the symptoms in the hands and feet. The pain and erythema were self-limiting and improved 11 days after capecitabine discontinuation and local supportive care.

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Section: Discussionmentioning

confidence: 99%

Palmar-plantar Erythrodysesthesia with Genital Involvement Secondary to Capecitabine Chemoradiotherapy: A Case Report

Hu¹,

Corkum²,

Perera³

2018

Cureus

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“…Another report described a patient who suffered from balanitis after undergoing the FOL-FIRI chemotherapy regimen, of which 5-FU is a key component. 43 Mechanistically, 5-fluorouracil has documented vascular modulatory effects, including endothelial-dependent vasoconstriction and microthrombosis, all of which could contribute to the development of balanitis. 44 Antipyretics and analgesics, such as nonsteroidal antiinflammatory drugs (NSAIDS) and acetaminophen, have been described as possible causes of drug-induced balanitis.…”

Section: Drug-induced Balanitismentioning

confidence: 99%

“…All infectious etiologies were ruled out, and the patient was successfully treated with corticosteroids. Another report described a patient who suffered from balanitis after undergoing the FOLFIRI chemotherapy regimen, of which 5‐FU is a key component 43 . Mechanistically, 5‐fluorouracil has documented vascular modulatory effects, including endothelial‐dependent vasoconstriction and microthrombosis, all of which could contribute to the development of balanitis 44 …”

Section: Drug‐induced Balanitismentioning

confidence: 99%

Urologic dermatology: a comprehensive foray into the noninfectious etiologies of balanitis

et al. 2021

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Balanitis is classically defined as inflammation of the glans penis, often also encompassing the prepuce (balanoposthitis). Several investigations have found that a sizable proportion of urology clinic visits are due to balanitis or related complaints. Balanitis can have numerous complications, including severe pain, urethral stenosis, phimosis, sexual dysfunction, and if untreated, malignancy. Unfortunately, there is no recent or comprehensive review that describes the various etiologies, clinical workup, and treatments for balanitis. Herein this review, we attempt to provide the reader with a complete and updated guide to balanitis in an attempt to improve clinical outcomes. Dogra et al, 69 Calcineurin Inhibitors -Tacrolimus ointment 0.3 mg/g Malignancy risk Ly et al., 71 Blauvelt et al. 70 Monoclonal Antibodies -Ustekinumab -45mg/90mg depending on weight; Secukinumab -300 mg Infection, malignancy, GI upset

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Fluorouracil/folinic acid/irinotecan

2018

Reactions Weekly

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Balanitis associated with FOLFIRI chemotherapy

Cited by 4 publications

References 16 publications

Palmar-plantar Erythrodysesthesia with Genital Involvement Secondary to Capecitabine Chemoradiotherapy: A Case Report

Palmar-plantar Erythrodysesthesia with Genital Involvement Secondary to Capecitabine Chemoradiotherapy: A Case Report

Urologic dermatology: a comprehensive foray into the noninfectious etiologies of balanitis

Fluorouracil/folinic acid/irinotecan

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