Balans en toekomst van de sociologie

Engbersen, Godfríed; Haan, de Jos

doi:10.5117/9789085551416

Cited by 5 publications

(4 citation statements)

References 66 publications

(82 reference statements)

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“…eVim's stimulatory effect on leukemic macrophage migration and phagocytosis aligns with our findings on human neutrophils (48). Secretion of vimentin by tumor endothelial cells can lead to immunosuppression, and vaccination to produce anti-vimentin antibodies shows efficacy in prolonging survival in dogs with bladder cancer (49). eVim's capability as a substrate for attachment and motility of various cell types underscores its diverse, context-dependent interactions (23).…”

Section: Discussionsupporting

confidence: 76%

Extracellular Vimentin is a Damage-Associated Molecular Pattern Protein Serving as an Agonist of TLR4 in Human Neutrophils

Suprewicz,

Fiedoruk,

Skłodowski

et al. 2024

Preprint

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Background Vimentin is a type III intermediate filament protein, that plays an important role in cytoskeletal mechanics. It is now known that vimentin also plays important roles outside the cell. Recent studies show the controlled release of vimentin into the extracellular environment, where it functions as a signaling molecule. Such observations are expanding our current knowledge of vimentin as a structural cellular component towards additional roles as an active participant in cell signaling. Methods Our study investigates the immunological roles of extracellular vimentin (eVim) and its citrullinated form (CitVim) as a damage-associated molecular pattern (DAMP) engaging the Toll-like receptor 4 (TLR4) of human neutrophils. We used in vitro assays to study neutrophil migration through endothelial cell monolayers and activation markers such as NADPH oxidase subunit 2 (NOX2/gp91phox). The comparison of eVim with CitVim and its effect on human neutrophils was extended to the induction of extracellular traps (NETs) and phagocytosis of pathogens. Results Both eVim and CitVim interact with and trigger TLR4, leading to increased neutrophil migration and adhesion. CitVim stimulated the enhanced migratory ability of neutrophils, activation of NF-kappaB, and induction of NET formation mainly mediated through reactive oxygen species (ROS)-dependent and TLR4-dependent pathways. In contrast, neutrophils exposed to non-citrullinated vimentin exhibited higher efficiency in favoring pathogen phagocytosis, such as Escherichia coli and Candida albicans, compared to CitVim. Conclusions Our study identifies new functions of eVim in its native and modified forms as an extracellular matrix DAMP and highlights its importance in the modulation of immune system functions. The differential effects of eVim and CitVim on neutrophil functions highlight their potential as new molecular targets for therapeutic strategies aimed at differential regulation of neutrophil activity in different pathological conditions. This, in turn, opens new windows of therapeutic intervention in inflammatory and immunological diseases characterized by immune system dysfunction, in which eVim and CitVim play a key role.

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Section: Discussionsupporting

confidence: 76%

Extracellular Vimentin is a Damage-Associated Molecular Pattern Protein Serving as an Agonist of TLR4 in Human Neutrophils

Suprewicz,

Fiedoruk,

Skłodowski

et al. 2024

Preprint

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“…Dit terwijl sommige wetenschappers een geëngageerde houding hebben aangenomen en in hun publicaties een hoge mate van prescriptie doorklinkt. Het durven te zeggen 'waar het naar toe moet', volgens velen een belangrijk onderdeel van de maatschappelijke rol van de sociologie (Engbersen & De Haan, 2006), heeft in veel gevallen niet het gewenste effect van beleidsbeïnvloeding gehad.…”

Section: Rio De Janeiro December 2005unclassified

Hooligans, fans en fanatisme : Een internationale vergelijking van club- en supportersculturen

Spaaij¹

2008

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Hooligans, fans en fanatisme Hooligans, fans en fanatisme Een internationale vergelijking van cluben supportersculturen Ramón SpaaijOmslagafbeelding: Ramón Spaaij VoorwoordHet onderzoek waarop dit boek is gebaseerd heeft me op plaatsen gebracht die de (neutrale) voetballiefhebber als muziek in de oren zullen klinken: Wembley, Maracanã, Camp Nou, Upton Park, Santiago Bernabéu, enzovoort. Daarnaast heeft het me geleid naar de obscuurdere regionen van het voetbal, waarvan mijn bezoek aan de heetgebakerde derby tussen Union Berlin en BFC Dynamo Berlin me in ieder geval zal bijblijven. Op al deze plaatsen, en zeker ook bij de Amsterdamse School voor Sociaal-wetenschappelijk Onderzoek (ASSR), heb ik boeiende mensen ontmoet. Zij hebben, ieder op een geheel eigen wijze, een belangrijke bijdrage geleverd. Ik kan alleen maar hopen dat zij hun inspanningen beloond zien in het resultaat.Een speciaal woord van dank gaat uit naar de volgende personen: Kees

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“…Sociologists have recently pointed out the social implications of the eiects of the combative pandemic governance through the decline of institutional trust (Engbersen 2022;Snel et al 2024). Trust in the central government of the Netherlands declined from 69% at the start of the pandemic to 22% in September 2023, with similar declines in trust in the local government and in the National Institute for Public Health and the Environment (ibid., p. 5).…”

Section: Introduction: Urban Living Labs and Epistemic Justice In Pos...mentioning

confidence: 99%

“…Trust in the central government of the Netherlands declined from 69% at the start of the pandemic to 22% in September 2023, with similar declines in trust in the local government and in the National Institute for Public Health and the Environment (ibid., p. 5). Following Engbersen (2022), the pandemic has not been the great equalizer that it was framed as in its early days. In this paper, I take institutional distrust as the public face of epistemic trust injustices.…”

Section: Introduction: Urban Living Labs and Epistemic Justice In Pos...mentioning

confidence: 99%

Urban Living Labs in times of post-pandemic epistemic injustices: a speculative realist revision

Pijpers

2024

Preprint

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The Urban Living Lab (ULL) is an aspirational device to materialize practices designed around co- production, participation, and transformation in the public arena. It is a research approach that emphasizes short-lived in-situ collaborations purified from the wider ex-situ political and social reality. This approach can strengthen epistemic trust injustices and harms by enforcing an overbearing mode of consensus-seeking participation around dominant epistemic regimes. This paper formulates an alternative, speculative realist approach to the ULL and analyses an ethnographic vignette to explore the intricacies, ambiguities, and disagreements within a post- pandemic ULL-situation in a community playground in Rotterdam South. Through these analyses, this paper takes inventory of matters of care in this stigmatized territory to show how an ULL might be done if it is to generate epistemic justice and social transformation.

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Balans en toekomst van de sociologie

Cited by 5 publications

References 66 publications

Extracellular Vimentin is a Damage-Associated Molecular Pattern Protein Serving as an Agonist of TLR4 in Human Neutrophils

Extracellular Vimentin is a Damage-Associated Molecular Pattern Protein Serving as an Agonist of TLR4 in Human Neutrophils

Hooligans, fans en fanatisme : Een internationale vergelijking van club- en supportersculturen

Urban Living Labs in times of post-pandemic epistemic injustices: a speculative realist revision

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