BALB/c Mice resist infection with Bartonella bacilliformis

Infante, Berónica; Villar, Sandra; Palma, Sandra; Merello, Jenny; Valencia, Roberto; Torres, Luís; Cok, Jamie; Ventosilla, Palmira; Manguiña, Ciro; Guerra, Humberto; Henríquez, César

doi:10.1186/1756-0500-1-103

Cited by 7 publications

(5 citation statements)

References 16 publications

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“…In particular, persistent bacteremia as the hallmark of reservoir host infection was obtained only when using reservoir host models (134,165,233,236,242,330,394). Attempts to infect nonreservoir hosts with bartonellae resulted neither in verifiably intraerythrocytic bacteremia nor in persistent infection (92,134,195,213). However, it is known that the host range of Bartonella does not strictly follow the taxonomic borders on the species level but may include a few closely related species, so that B. quintana has been reported to infect not only humans but also rhesus macaques, both naturally and upon experimental inoculation (190,450).…”

Section: Host Specificitymentioning

confidence: 99%

Intruders below the Radar: Molecular Pathogenesis of Bartonella spp

2012

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SUMMARY Bartonella spp. are facultative intracellular pathogens that employ a unique stealth infection strategy comprising immune evasion and modulation, intimate interaction with nucleated cells, and intraerythrocytic persistence. Infections with Bartonella are ubiquitous among mammals, and many species can infect humans either as their natural host or incidentally as zoonotic pathogens. Upon inoculation into a naive host, the bartonellae first colonize a primary niche that is widely accepted to involve the manipulation of nucleated host cells, e.g., in the microvasculature. Consistently, in vitro research showed that Bartonella harbors an ample arsenal of virulence factors to modulate the response of such cells, gain entrance, and establish an intracellular niche. Subsequently, the bacteria are seeded into the bloodstream where they invade erythrocytes and give rise to a typically asymptomatic intraerythrocytic bacteremia. While this course of infection is characteristic for natural hosts, zoonotic infections or the infection of immunocompromised patients may alter the path of Bartonella and result in considerable morbidity. In this review we compile current knowledge on the molecular processes underlying both the infection strategy and pathogenesis of Bartonella and discuss their connection to the clinical presentation of human patients, which ranges from minor complaints to life-threatening disease.

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Section: Host Specificitymentioning

confidence: 99%

Intruders below the Radar: Molecular Pathogenesis of Bartonella spp

2012

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“…This is largely due to the lack of an inexpensive in vivo animal model. Although BALB/c mice resist infection by B. bacilliformis [110] , a SCID/BEIGE murine model for studying Bartonella infection may prove useful, but has not been tested in this regard [111] . Garcia et al investigated the effect of B. bacilliformis extracts on human endothelial cells in vitro as well as in an in vivo model of angiogenesis consisting of subcutaneous implantation of sponge discs containing bacterial extracts into adult Sprague-Dawley rats [103] .…”

Section: Host Cell Parasitism Angiogenesis and Immune Responsementioning

confidence: 99%

Oroya Fever and Verruga Peruana: Bartonelloses Unique to South America

et al. 2014

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Bartonella bacilliformis is the bacterial agent of Carrión's disease and is presumed to be transmitted between humans by phlebotomine sand flies. Carrión's disease is endemic to high-altitude valleys of the South American Andes, and the first reported outbreak (1871) resulted in over 4,000 casualties. Since then, numerous outbreaks have been documented in endemic regions, and over the last two decades, outbreaks have occurred at atypical elevations, strongly suggesting that the area of endemicity is expanding. Approximately 1.7 million South Americans are estimated to be at risk in an area covering roughly 145,000 km2 of Ecuador, Colombia, and Peru. Although disease manifestations vary, two disparate syndromes can occur independently or sequentially. The first, Oroya fever, occurs approximately 60 days following the bite of an infected sand fly, in which infection of nearly all erythrocytes results in an acute hemolytic anemia with attendant symptoms of fever, jaundice, and myalgia. This phase of Carrión's disease often includes secondary infections and is fatal in up to 88% of patients without antimicrobial intervention. The second syndrome, referred to as verruga peruana, describes the endothelialcell-derived, blood-filled tumors that develop on the surface of the skin. Verrugae are rarely fatal, but can bleed and scar the patient. Moreover, these persistently infected humans provide a reservoir for infecting sand flies and thus maintaining B. bacilliformis in nature. Here, we discuss the current state of knowledge regarding this life-threatening, neglected bacterial pathogen and review its host-cell parasitism, molecular pathogenesis, phylogeny, sand fly vectors, diagnostics, and prospects for control.

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“…The sheep blood supplement allows the culture of most culturable bacteria, regardless of their metabolic requirements 1 . Columbia blood agar has been used to cultivate bacteria from different animal taxa including birds (Ruiz-de-Castañeda et al, 2011b;Merbach et al, 2019) and mammals (Infante et al, 2008;Di et al, 2020).…”

Section: Bacteria Sampling and Cultivation Proceduresmentioning

confidence: 99%

First Evidence of a Relationship Between Female Major Histocompatibility Complex Diversity and Eggshell Bacteria in House Sparrows (Passer domesticus)

et al. 2021

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Bacteria are known to exert positive and negative influences on animals’ health and fitness. Bacteria, in particular those inhabiting the skin and inner organs of vertebrates, are horizontally or vertically transmitted. Specifically, mothers of bird species can transfer bacterial strains to their offspring when the egg is passing the reproductive tract, as the eggshell rubs against the wall of the uterus. In this context, the female immune system might play an important role in influencing the vertical transmission of bacteria. Here, we investigate the relationship between the major histocompatibility complex (MHC) and cultivable eggshell bacteria originating putatively from the female urogenital tract in a captive population of house sparrows (Passer domesticus). We predict that females with a more variable MHC will transfer fewer bacteria onto the eggshells. Our results show a negative relationship between the number of functional MHC class I alleles and bacteria originating in the urinary tract and growing on a selective medium. This is the first study to find a correlation between female MHC diversity and eggshell bacteria.

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BALB/c Mice resist infection with Bartonella bacilliformis

Cited by 7 publications

References 16 publications

Intruders below the Radar: Molecular Pathogenesis of Bartonella spp

Intruders below the Radar: Molecular Pathogenesis of Bartonella spp

Oroya Fever and Verruga Peruana: Bartonelloses Unique to South America

First Evidence of a Relationship Between Female Major Histocompatibility Complex Diversity and Eggshell Bacteria in House Sparrows (Passer domesticus)

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