First Evidence of a Relationship Between Female Major Histocompatibility Complex Diversity and Eggshell Bacteria in House Sparrows (Passer domesticus)

Darolová, Alžbeta; Poláček, Miroslav; Krištofík, Ján; Lukasch, Barbara; Hoi, Herbert

doi:10.3389/fevo.2021.615667

Cited by 3 publications

(3 citation statements)

References 63 publications

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“…The influence of the MHC haplotype on the microbiome has been studied in all major vertebrate groups including fish (Bolnick et al, 2014), amphibians (Belasen et al, 2021;Hernández Gómez, Briggler, & Williams, 2018), birds (Darolová, Poláček, Krištofík, Lukasch, & Hoi, 2021;Leclaire et al, 2019), and mammals (Khan et al, 2019;Kubinak et al, 2015;P. Lin et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Association between the skin microbiome and MHC class II diversity in an amphibian

Cortázar-Chinarro

Richter‐Boix

Rödin‐Mörch

et al. 2023

Preprint

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It has become clear that the microbiome plays an important role in determining host health, diseases, and phenotypic variation. There is increasing evidence that the microbiome influences host fitness and its adaptation to the environment is changing our thinking on host-microbe interactions. However, it remains unclear how a host genotype shapes its microbiome. Here, we explored how genetic background and evolutionary history influence associated microbiome in amphibian populations. We studied how skin bacterial diversity is associated with the Major Histocompatibility Complex (MHC) class II exon 2 diversity in 12 moor frog populations belonging to two geographical clusters that show signatures of past and ongoing differential selection patterns. We found that bacterial alpha-diversity remained similar between the two clusters, while MHC haplotype-supertypes and genetic diversity differed between the clusters. Bacterial alpha-diversity was positively correlated with expected MHC heterozygosity and negatively with MHC nucleotide diversity. We also found that bacterial community composition differed significantly between the two geographic clusters and between specific MHC supertypes. These findings further suggest that population historical demographic events influence hologenomic variation and provide new insights into how immunogenetic host variability and microbial diversity may jointly influence host fitness with consequences for disease susceptibility and population persistence.

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Section: Introductionmentioning

confidence: 99%

Association between the skin microbiome and MHC class II diversity in an amphibian

Cortázar-Chinarro

Richter‐Boix

Rödin‐Mörch

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…The influence of MHC genotype on microbiome diversity and composition has been studied for all major vertebrate groups, including fish (Bolnick et al., 2014), amphibians (Belasen et al., 2021; Hernández‐Gómez et al., 2018), birds (Darolová et al., 2021; Leclaire et al., 2019) and mammals (Khan, Stephens, et al., 2019; Kubinak et al., 2015; Lin et al., 2014). In humans, MHC (known as human leukocyte antigen, HLA) variants have been found to be influenced by the composition of the microbiome (Bolnick et al., 2014; Bonder et al., 2016).…”

Section: Introductionmentioning

confidence: 99%

Association between the skin microbiome and MHC class II diversity in an amphibian

Cortazar‐Chinarro,

Richter‐Boix,

Rödin‐Mörch

et al. 2023

Molecular Ecology

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Microbiomes play an important role in determining the ecology and behaviour of their hosts. However, questions remain pertaining to how host genetics shape microbiomes, and how microbiome composition influences host fitness. We explored the effects of geography, evolutionary history and host genetics on the skin microbiome diversity and structure in a widespread amphibian. More specifically, we examined the association between bacterial diversity and composition and the major histocompatibility complex class II exon 2 diversity in 12 moor frog (Rana arvalis) populations belonging to two geographical clusters that show signatures of past and ongoing differential selection. We found that while bacterial alpha diversity did not differ between the two clusters, MHC alleles/supertypes and genetic diversity varied considerably depending on geography and evolutionary history. Bacterial alpha diversity was positively correlated with expected MHC heterozygosity and negatively with MHC nucleotide diversity. Furthermore, bacterial community composition showed significant variation between the two geographical clusters and between specific MHC alleles/supertypes. Our findings emphasize the importance of historical demographic events on hologenomic variation and provide new insights into how immunogenetic host variability and microbial diversity may jointly influence host fitness with consequences for disease susceptibility and population persistence.

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“…For example, in house sparrows, Passer domesticus, specific MHC class I alleles are associated with stronger immune T cell responses to MHC I presented antigen [22] and increased resistance to malaria parasites [23,24]. Furthermore, house sparrow females exhibiting lower numbers of functional MHC I alleles lay eggs with more eggshell bacteria [25], and some MHC genes have been found to partly explain early survival in this species [26]. Consequently, both pathogen-mediated selection [27] and sexual selection [28][29][30][31] may explain the maintenance of MHC polymorphism.…”

Section: Introductionmentioning

confidence: 99%

House sparrows do not exhibit a preference for the scent of potential partners with different MHC-I allele numbers and genetic distances

Amo

Paz

Kabbert

et al. 2022

Preprint

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MHC genes play a fundamental role in immune recognition of pathogens and parasites. Therefore, females may increase offspring heterozygosity and genetic diversity by selecting MHC genetically compatible or heterozygous males. In birds, several studies suggest that MHC genes play a role in mate choice, and recent evidence suggest that olfaction may play a role in such discrimination. Previous studies indicated that house sparrow females with low allelic diversity prefer males with higher diversity in MHC-I alleles. Here, we directly explored whether both house sparrow females and males could estimate by scent the number in MHC amino acid and functional variants as well as the level of MHC-I similarity or dissimilarity of potential partners. Our results show that neither females nor males exhibit a preference related to the number of MHC-I amino acid variants or functional variants or in relation to MHC amino acid or functional similarity of potential partners, suggesting that MHC-I is not detected through olfaction. Further studies are needed to understand the mechanisms responsible for MHC-I based mate discrimination in birds.

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First Evidence of a Relationship Between Female Major Histocompatibility Complex Diversity and Eggshell Bacteria in House Sparrows (Passer domesticus)

Cited by 3 publications

References 63 publications

Association between the skin microbiome and MHC class II diversity in an amphibian

Association between the skin microbiome and MHC class II diversity in an amphibian

Association between the skin microbiome and MHC class II diversity in an amphibian

House sparrows do not exhibit a preference for the scent of potential partners with different MHC-I allele numbers and genetic distances

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