Balkan nephropathy

Djukanović, Ljubica; Radovanović, Zoran

doi:10.1007/978-0-387-84843-3_38

Cited by 3 publications

(2 citation statements)

References 49 publications

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“…With respect to BEN, which is geographically confined to families living near tributaries of the Danube River in Bosnia, Bulgaria, Croatia, Romania and Serbia [ 7 , 36 ], the estimated prevalence of the use of AA ranges between 2% and 10% [ 37 ]. Based on a more profound screening, the idea has been put forward that even the suspected cases need to be included, by which the prevalence increases up to 20% in endemic areas [ 37 ].…”

Section: Aristolochic Acid Nephropathymentioning

confidence: 99%

Environmental toxin-induced acute kidney injury

Vervaet

D’Haese

Verhulst

2017

Clinical Kidney Journal

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Human beings are exposed to various potentially toxic agents and conditions in their natural and occupational environments. The kidney, due to its concentrating ability and excretory function, is highly vulnerable to the effects of environmental toxins. Identifying the precise cause and mechanisms of environmentally induced renal injury remains a challenge for which various scientific disciplines need to be involved. Investigations in this field are confronted with the apparent infinite types of toxins, their mutual interaction, handling/metabolization by the body, ways of exposure, etc. Although interdisciplinary efforts and persistence are required to identify, mechanistically unravel and tackle environmental toxin–induced pathologies, research eventually pays off in ameliorated working/living conditions and development of preventive/therapeutic strategies. This review was compiled to particularly emphasize the need for a maintained awareness of environmental threats in general and those targeting the kidney. Different mechanisms of renal toxicity are illustrated and discussed, thereby focusing on three types of environmental toxins, namely aristolochic acid, melamine and heavy metals.

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Section: Aristolochic Acid Nephropathymentioning

confidence: 99%

Environmental toxin-induced acute kidney injury

Vervaet

D’Haese

Verhulst

2017

Clinical Kidney Journal

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“…Balkan endemic nephropathy (BEN) is a familial, slow progressive tubule-interstitial disease characterized by tubular proteinuria, mild hypertension and in the advanced stage by severe anemia [1]. For BEN patients, data on chronic kidney disease-mineral and bone disorder (CKD-MBD) as well as findings concerning vascular calcification (VC) are scarce and insufficient [2,3,4].…”

Section: Introductionmentioning

confidence: 99%

Differences in Risk Factors and Prevalence of Vascular Calcification between Pre-Dialysis and Hemodialysis Balkan Nephropathy Patients

Petković¹,

Ristić

Marinković

et al. 2018

Medicina

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Aims: The aim of this study was to compare the risk factors and prevalence of vascular calcification (VC) in pre-dialysis and hemodialysis (HD) patients with Balkan endemic nephropathy (BEN) or other kidney diseases (non-BEN). Materials and Methods: The study involved 115 patients, 32 pre-dialysis and 83 HD patients, separated into groups of BEN and non-BEN patients. In addition to interviews, objective examinations and laboratory analyses, VC was assessed using Adragao score. Results: Patients with BEN were significantly older in both groups, while pre-dialysis BEN patients had significantly lower systolic blood pressure, serum cholesterol and phosphorus levels, but higher urinary excretion of phosphorus than non-BEN patients. These differences were lost in HD groups. In pre-dialysis patients, prevalence of VC was lower in BEN than in non-BEN group and mean VC score differed significantly between them (2.8 (1.7) vs. 4.6 (1.8); p = 0.009). No significant difference in VC score was found between BEN and non-BEN patients on HD. Multivariate analysis showed that in pre-dialysis patients VC score >4 was associated with lower iPTH and higher serum cholesterol level, but in the HD group with higher serum triglyceride level and longer HD vintage. Conclusions: Lower prevalence of risk factors for VC in the BEN than non-BEN patients was found in pre-dialysis but not in HD group and this was reflected in the prevalence and severity of VC in the groups. Prevalence of VC and mean VC score were significantly lower in pre-dialysis BEN than in non-BEN patients but not for those on HD.

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Biomarkers of oxidative damage and antioxidant enzyme activities in pre-dialysis Balkan endemic nephropathy patients

Pavlović¹,

Savić-Radojević

Plješa-Ercegovac

et al. 2016

Int Urol Nephrol

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Based on our results on increased oxidative protein damage in both pre-dialysis BEN patients and healthy BEN family members, it can be speculated that individuals from BEN areas, in general, are chronically exposed to some prooxidant environmental compounds. Moreover, decrease in plasma GPX activity, as a consequence of impaired kidney function, could further affect oxidative status in BEN patients.

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Balkan nephropathy

Cited by 3 publications

References 49 publications

Environmental toxin-induced acute kidney injury

Environmental toxin-induced acute kidney injury

Differences in Risk Factors and Prevalence of Vascular Calcification between Pre-Dialysis and Hemodialysis Balkan Nephropathy Patients

Biomarkers of oxidative damage and antioxidant enzyme activities in pre-dialysis Balkan endemic nephropathy patients

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