Banding cytogenetic analysis in pediatric patients with acute lymphoblastic leukemia (ALL) in a Brazilian population

Abstract

BackgroundCytogenetic studies in Brazilian population about childhood acute lymphoblastic leukemia (ALL), the most common childhood malignancy, are scarce. Moreover, Brazilian race is very heterogeneous and is made by the confluence of people of several different origins, from the original Native Brazilians, with the influx of Portuguese colonizers, Black African slaves, and recent European, Arab and Japanese immigration. The purpose of this prospective, multicentric study was to assess the sociodemographic, clinic and cytogenetic characteristics of the children treated for ALL in the Northeast region of Brazil.ResultsThis study includes thirty patients between 4 months and 17 years old treated for ALL from January 1st, 2009 to November 30th, 2010. Cytogenetic analysis showed that in nineteen out of thirty patients (64%) presented some chromosome abnormalities, in which 53% corresponds to numerical abnormalities, 21% structural and numerical abnormalities, and 26% only structural changes. Moreover, seven patients presented complexes karyotype not yet described in the literature. Taken together these results show the importance of the cytogenetic analysis in ALL pediatric patients and illustrates that the studied population presented unexpected complexes karyotypes which were correlated to poor outcome.ConclusionThe results demonstrate the importance of banding cytogenetics for ALL diagnosis despite the use of most modern techniques such as FISH and aCGH, and provide reliable insight into the ALL in Brazil.

Cytogenetic and Molecular Findings in Children with Acute Lymphoblastic Leukemia: Experience of a Single Institution in Argentina

“…Approximately 75% of childhood ALL cases harbor CAs detected by conventional cytogenetics and FISH. However, the percentage varies from 55 up to 89% in different series 200 depending on the number of patients studied, the year they were reported, and the populations where they have been studied [Chessels et al, 1997;Andreasson et al, 2000;Forestier et al, 2000;De Braekeleer et al, 2010;Moorman et al, 2010;Gil et al, 2013]. We report the cytogenetic findings in 1,057 children with ALL studied in our center, spanning a period of 23 years.…”

Chromosomal Abnormalities in Pakistani Children with Acute Lymphoblastic Leukemia

“…Cytogenetic analysis in hematological malignancies like many other diseases, plays a significant role in understanding the pathophysiology as well as clinical behavior of the condition (Mazloumi et al, 2012;Gil et al, 2013). In fact, for acute lymphoblastic leukemia, like other malignant conditions, karyotype is one of the prognostic indicators (Borowitz et al, 2008;Iacobucci et al, 2012).…”

Acute Lymphoblastic Leukemia

“…Another previous study 13 showed chromosomal abnormalities in 64% of cases. The numerical abnormalities involved 53% of the cases followed by 26% cases revealing structural abnormalities.…”