Purpose of the research. The purpose of the study is to explore the financial, technical, technological and resource aspects of modelling state management priorities in the context of globalization. Methodology. The following special methods of scientific cognition were used in the research process: historical-logical method; method of systematization, classification and theoretical generalization; method of institutional analysis; method of system analysis; method of logical analysis and synthesis; method of graphic analysis. Results. It is determined that in the process of formation of state priorities of business development it is necessary to take into account scenario foresights of innovative economy and on this basis to form own strategy of definition of state priorities. The stages of definition of the state priorities of business development in innovative economy according to the scenario “New innovative course” are offered. It is specified that the effectiveness of the implementation of the proposed stages is directly dependent on the intellectual level of government officials, their administrative experience in the direction of strategy. This update identifies the need to reform the labour market and the infrastructure elements represented in it. The priority of state regulation of the infrastructure of business development and the need to create a critical mass of intellectual human resources in the labour market are determined. Practical meaning. According to the presented research, the developed format of horizontal and vertical relations between participants of the institutional system - researchers, innovative entrepreneurs, venture investors and institutes of support of innovative entrepreneurship is of practical importance, which is a key and necessary condition for creating a successful innovation system. Prospects for further research. Given that the main supplier of intellectual potential for entrepreneurship is the labour market, emphasis is placed on the need to take it into account when forming a mechanism of state support for innovative development of entrepreneurship. The directions of business infrastructure improvement necessary for realization of neo-innovative formation methodology of the state priorities of business development at the national level are offered.