BarH-like homeobox 2 represses the transcription of keratin 16 and affects Ras signaling pathway to suppress nasopharyngeal carcinoma progression

Lu, Zhibing; Peng, Hui; Li, Ruijuan; Xu, Xinyan; Peng, Jiyong

doi:10.1080/21655979.2022.2026549

Cited by 5 publications

(2 citation statements)

References 30 publications

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“…First, the role of BARX2 in tumorigenesis may be different among different cancers. Although BARX2 expression is upregulated in various types of tumours, such as lung adenocarcinoma, ovarian serous adenocarcinoma and nasopharyngeal cancers 25 , 32 , 33 , the current study shows that BARX2 is also expressed downregulated in different types of tumours such as breast, gastric and colon cancers 24 , 29 , 31 , suggesting that BARX2 expression is tissue specific. However, Stevens and Meech et al found increased expression of BARX2 in breast cancer tissues 31 , with upregulation of the expression of MMP9 and inhibitor of metalloproteinases 4 (TIMP4), which ultimately promoted invasion and migration of breast cancer cells, contradicting our current results, probably due to differences in the tumour tissue subtypes studied.…”

Section: Discussioncontrasting

confidence: 47%

Pancancer analysis of oncogenic BARX2 identifying its prognostic value and immunological function in liver hepatocellular carcinoma

Yang

et al. 2023

Sci Rep

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The transcription factor BarH-like homeobox 2 (BARX2), a member of the Bar-like homeobox gene family, is involved in cell proliferation, differentiation, immune responses and tumorigenesis. However, the potential role of BARX2 in the development of liver hepatocellular carcinoma (LIHC) remains unclear. Therefore, we aimed to study the biological role of BARX2 in hepatocellular carcinoma. Through the UALCAN, GTEx PORTAL, TIMER 2.0, LinkedOmics, SMART, MethSurv, Metascape, GSEA and STRING public databases, the BARX2 mRNA level, prognostic value, coexpressed genes, associated differentially expressed genes, DNA methylation and functional enrichment of LIHC patients were studied. The relationships between BARX2 expression and various clinical or genetic parameters of LIHC patients were determined using data from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and BEAT LIHC databases. In addition, the biological function of BARX2 in LIHC was studied in vitro. Through large-scale data mining, our study showed that BARX2 was differentially expressed between different normal and tumour tissues.BARX2 expression in LIHC tissues was significantly lower than that in corresponding controls, especially in patients with T2-4 stage disease. In patients with LIHC, overexpression of BARX2 was an independent poor prognostic factor associated with poor cytogenetic risk and gene mutations. Genomic hypermethylation of the BARX2 gene was associated with upregulated BARX2 expression and poor overall survival (OS) in LIHC. Functional enrichment analysis showed that BARX2 had an immunomodulatory role and was involved in the inflammatory response in LIHC occurrence. In conclusion, the oncogene BARX2 may serve as a new biomarker and prognostic factor for patients with LIHC. The immunomodulatory function of BARX2 deserves further validation in LIHC.

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Section: Discussioncontrasting

confidence: 47%

Pancancer analysis of oncogenic BARX2 identifying its prognostic value and immunological function in liver hepatocellular carcinoma

Yang

et al. 2023

Sci Rep

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“…First, the role of BARX2 in tumorigenesis may be different in different cancers. Although BARX2 expression is upregulated in various types of tumors such as Lung adenocarcinoma, ovarian serous adenocarcinoma and nasopharyngeal cancers [44,51,52], the current study shows that BARX2 is also expressed downregulated in different types of tumors such as breast, gastric and colon cancers [24,48,50], suggesting that BARX2 expression is tissue-speci c. However, Stevens and Meech et al found increased expression of BARX2 in breast cancer tissues [50], while upregulating the expression of MMP9 and inhibitor of metalloproteinases 4 (TIMP4), which ultimately promotes invasion, migration of breast cancer cells, contradicting our current results, probably due to differences in the tumor tissue subtypes studied. On the other hand, the prognostic value of BARX2 expression in cancer patients has been little reported so far [53].…”

Section: Discussionmentioning

confidence: 99%

Pan-cancer analysis of oncogenic BARX2 identifying its prognostic value and immunological function in Liver hepatocellular carcinoma

Yang

et al. 2022

Preprint

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Transcription factor BarH-like homeobox 2 ( BARX2 ), a member of the Bar-like homeobox gene family,involved in cell proliferation, differentiation, immune response and tumorigenesis. However, the potential role of BARX2 in the development of Liver hepatocellular carcinoma ( LIHC ) remains unclear. Therefore, we aimed to study the biological role of BARX2 in hepatocellular carcinoma.Through UALCAN, GTEx PORTAL, TIMER 2.0, LinkedOmics, SMART, MethSurv, Metascape, GSEA and STRING public databases, the BARX2 mRNA level, prognostic value, co-expressed genes, differentially expressed genes, DNA methylation and functional enrichment analysis of LIHC patients were studied. The relationship between BARX2 expression and various clinical or genetic parameters of LIHC patients was determined using data from the Cancer Genome Atlas ( TCGA ), Gene Expression Omnibus ( GEO ), and BEAT LIHC databases. In addition, the biological function of BARX2 in LIHC was studied in vitro. Through large-scale data mining, our study shows that BARX2 is differentially expressed in different normal and tumor tissues. BARX2 expression in LIHC tissues was significantly lower than in the corresponding controls, especially in patients with T2-4 stage. In patients with LIHC, overexpression of BARX2 is an independent poor prognostic factor associated with poor cytogenetic risk and gene mutations. Genomic hypermethylation of the BARX2 gene was associated with upregulated BARX2 expression and low OS in LIHC. Functional enrichment analysis showed that BARX2 has an immunomodulatory role and inflammatory response in LIHC occurrence.In conclusion, the oncogene BARX2 may serve as a new biomarker and prognostic factor for patients with LIHC. the immunomodulatory function of BARX2 deserves further validation in LIHC.

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Molecular mechanism of FBXW7-mediated ubiquitination modification in nasopharyngeal carcinoma cell proliferation in vitro and in vivo

Zhong

Wang

Kang

et al. 2023

Pathology - Research and Practice

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BarH-like homeobox 2 represses the transcription of keratin 16 and affects Ras signaling pathway to suppress nasopharyngeal carcinoma progression

Cited by 5 publications

References 30 publications

Pancancer analysis of oncogenic BARX2 identifying its prognostic value and immunological function in liver hepatocellular carcinoma

Pancancer analysis of oncogenic BARX2 identifying its prognostic value and immunological function in liver hepatocellular carcinoma

Pan-cancer analysis of oncogenic BARX2 identifying its prognostic value and immunological function in Liver hepatocellular carcinoma

Molecular mechanism of FBXW7-mediated ubiquitination modification in nasopharyngeal carcinoma cell proliferation in vitro and in vivo

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