Bariatric Roux-En-Y Gastric Bypass Surgery: Adipocyte Proteins Involved in Increased Bone Remodeling in Humans

Abstract

RYGB induced weight loss, and biochemical, hormonal, and body composition changes are associated with higher bone remodeling.

Effects of a High-Intensity Exercise Program on Weight Regain and Cardio-metabolic Profile after 3 Years of Bariatric Surgery: A Randomized Trial

“…To our knowledge, most studies have measured body composition between 6 and 24 months after surgery. According to these studies, a biphasic loss of fat mass can be observed: an initial fast phase of fat mass reduction during the first year after surgery, that is followed by a second phase in which fat loss slows down until it reaches a point of maximum fat mass loss at month 24 20 . However, studies that have a longer follow-up period Table 1.…”

Thin bones: Vitamin D and calcium handling after bariatric surgery

“…These serum markers help to evaluate the degree of bone resorption versus bone formation after bariatric surgery and assist to determine the types of changes in bone turnover that lead to bone loss. For RYGB, numerous clinical studies showed major increases in bone resorption markers such as CTX and TRACP 5b, but only small increases in bone formation markers P1NP and OC ( Obinwanne et al, 2014 ; Casagrande et al, 2012 ; Shanbhogue et al, 2017 ; Yu et al, 2015 ; Muschitz et al, 2015 ; Bredella et al, 2017 ; Elias et al, 2014 ; Yu et al, 2016b ; Ivaska et al, 2017 ; Stein et al, 2013 ; von Mach et al, 2004 ; Coates et al, 2004 ; Riedt et al, 2006 ; Riedl et al, 2008 ; Fleischer et al, 2008 ; Carlin et al, 2009 ; Bruno et al, 2010 ; Yu et al, 2014 ; Sinha et al, 2011 ; Yu, 2014 ; Biagioni et al, 2017 ; Hofsø et al, 2016 ). After SG, an increase in resorption markers has also been noticed, however this was less pronounced than after RYGB ( Muschitz et al, 2015 ; Bredella et al, 2017 ; Ivaska et al, 2017 ; Stein et al, 2013 ; Schollenberger et al, 2015 ).…”

“…Consistent herewith, vitamin D 3 deficiency is associated with low leptin levels ( Wagner et al, 2017 ). After SG and RYGB, serum leptin levels decrease due to loss of adipose tissue ( Shanbhogue et al, 2017 ; Biagioni et al, 2017 ; Grethen et al, 2012 ), whereas adiponectin levels increase ( Shanbhogue et al, 2017 ; Carrasco et al, 2014 ; Biagioni et al, 2017 ; Grethen et al, 2012 ; Carrasco et al, 2009 ). BMD was decreased in the limited number of studies in which BMD and adipokines were measured together ( Shanbhogue et al, 2017 ; Carrasco et al, 2014 ; Carrasco et al, 2009 ).…”

Neuroendocrine regulation of energy balance: Implications on the development and surgical treatment of obesity

“… AGB: adjustable gastric banding; VGB: Vertical Gastric Banding; RYGB: Roux-en-Y gastric bypass; SG: sleeve gastrectomy; BPD: biliopancreatic diversion; AgRP: agouti-related protein; α-MSH: alpha-melanocyte-stimulating hormone; CART: cocaine and amphetamine-regulated transcript; MCH: melatonin-concentrating hormone; NPY: neuropeptide Y; POMC: pro-opiomelanocortin; PP: polipeptide pancreatic; CCK: cholecystokinin; GIP: glucose-dependent insulinotropic polypeptide; GLP-1: glucagon-like peptide 1; GLP-2: glucagon-like peptide 2; OXM: oxyntomodulin; PYY: peptide YY; ↑: postsurgical increase; ↓: postsurgical decrease; ↔: no significant postsurgical change; T1: until 30-day follow up; T2: 3-month follow up T3: 6-month follow up; T4: 12-month follow up; T5: ≥24-month follow up. a Observational clinical studies only; b randomized clinical trials and observational clinical studies. 1 Netto et al (2016); 2 Tam et al (2016); 3 Urbanavicius et al (2013); 4 Bradley et al (2012); 5 Hansen et al (2011); 6 Netto et al (2015); 7 Chen et al (2012); 8 Illán-Gomez et al (2012); 9 Carrasco et al (2014); 10 Woelnerhanssen et al (2011); 11 Biagioni et al (2017); 12 Hoffstead et al (2017); 13 Garrido-Sanchéz et al (2012); 14 Palikhe et al (2014); 15 Haluzíková et al (2013); 16 Alam et al (2012); 17 Krieger et al (2012); 18 Jacobsen et al (2012); 19 Lips et al (2013); 20 Alamuddin et al (2017); 21 Ramón et al (2012); 22 Falkén et al (2011); 23 Nannipieri et al (2013); 24 Usinger et al (2011); 25 Umeda et al (2011); 26 Dirksen et al (2013); 27 Tsoli et al (2013); 28 Jorgensen et al (2012); 29 Rigamonti et al (2017); 30 Papamargaritis et al (2013); 31 Mallipedhi et al (2014); 32 Basso et al (2011); 33 Dixon et al (2011); 34 Peterli et al (2012); 35 Romero et al (2012); 36 Evans et al (201...…”

“… 1 Netto et al (2016); 2 Tam et al (2016); 3 Urbanavicius et al (2013); 4 Bradley et al (2012); 5 Hansen et al (2011); 6 Netto et al (2015); 7 Chen et al (2012); 8 Illán-Gomez et al (2012); 9 Carrasco et al (2014); 10 Woelnerhanssen et al (2011); 11 Biagioni et al (2017); 12 Hoffstead et al (2017); 13 Garrido-Sanchéz et al (2012); 14 Palikhe et al (2014); 15 Haluzíková et al (2013); 16 Alam et al (2012); 17 Krieger et al (2012); 18 Jacobsen et al (2012); 19 Lips et al (2013); 20 Alamuddin et al (2017); 21 Ramón et al (2012); 22 Falkén et al (2011); 23 Nannipieri et al (2013); 24 Usinger et al (2011); 25 Umeda et al (2011); 26 Dirksen et al (2013); 27 Tsoli et al (2013); 28 Jorgensen et al (2012); 29 Rigamonti et al (2017); 30 Papamargaritis et al (2013); 31 Mallipedhi et al (2014); 32 Basso et al (2011); 33 Dixon et al (2011); 34 Peterli et al (2012); 35 Romero et al (2012); 36 Evans et al (2012); 37 Yousseif et al (2014); 38 Cazzo et al (2017); 39 Malin et al (2014); 40 Gelisgen et al (2012); 41 Barazzonni et al (2013); 42 Dar et al (2012). …”