Barnidipine ameliorates the vascular and renal injury in l-NAME-induced hypertensive rats

Yıldırım, Funda; Kizilay, Deniz Eker; Ergin, Bülent; Ekmekçi, Özlem Balcı; Topal, Gökçe; Kuçur, Mine; Tansel, Cihan Demirci; Doğan, B. Sönmez Uydeş

doi:10.1016/j.ejphar.2015.07.033

Cited by 16 publications

(11 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reduction of SBP by EA could be related to antioxidant-induced improvement of vascular relaxation. In isolated arteries, the endothelium-dependent relaxation stimulated by ACh was significantly attenuated in the hypertensive group when compared to the control group, as reported in previous studies using hypertensive animals [25,26]. Herein, the impaired endothelial reactivity in arteries of hypertensive animals was attenuated by EA treatment.…”

Section: Discussionsupporting

confidence: 83%

Protective Effects of Ellagic Acid on Cardiovascular Injuries Caused by Hypertension in Rats

et al. 2017

View full text Add to dashboard Cite

Ellagic acid is described as having antioxidant and antiproliferative properties. Hence, it was hypothesized that ellagic acid could improve cardiovascular damage caused by hypertension. In this work, hypertension was induced in rats with N-Nitro-L-arginine methyl ester hydrochloride (60 mg/kg/day in drinking water) for 6 weeks. Ellagic acid was coadministered (10 or 30 mg/kg/day by gavage) between the second and sixth week. Blood pressure was recorded every week by tail-cuff plethysmography. After 6 weeks, the rats were sacrificed, the hearts and kidneys were weighed, and blood was collected. Aortas were isolated and set up to isometric recordings in an organ bath for histological assay and measuring of calcium content. Hypertension (233.6 ± 9.5 mmHg) was reduced (p < 0.01) by treatment with ellagic acid 10 or 30 mg/kg. The blood levels of nitrate/nitrite were reduced in hypertensive rats and the ellagic acid restored these levels. While the vascular relaxations to acetylcholine and sodium nitoprusside and the contraction to phenylephrine were impaired in the hypertensive group, they were improved after ellagic acid treatment. The alkaline phosphatase activity was increased by hypertension and returned to control levels after ellagic acid treatment. In the aorta, the administration of ellagic acid resulted in less aortic wall thickening and less calcification. In conclusion, ellagic acid attenuates hypertension, possibly improving nitric oxide bioavailability. The vascular response to acetylcholine, sodium nitroprusside, and phenylephrine was impaired by hypertension and improved after treatment with ellagic acid. Moreover, plasmatic alkaline phosphatase activity, calcium content, and hypertrophy in vascular tissues during hypertension were attenuated by treatment with ellagic acid.

show abstract

Section: Discussionsupporting

confidence: 83%

Protective Effects of Ellagic Acid on Cardiovascular Injuries Caused by Hypertension in Rats

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The reduction of SBP by HEJ could be related to antioxidant-induced improvement of vascular relaxation. In isolated arteries, the endothelium-dependent relaxation stimulated by ACh was significantly impaired in the hypertensive group when compared to the control group, as reported in previous studies using hypertensive animals [30, 31]. Herein, the impaired endothelial reactivity in arteries of hypertensive animals was attenuated by the HEJ treatment in both doses (Figure 4(a)).…”

Section: Resultssupporting

confidence: 84%

Radical Scavenger Capacity of Jabuticaba Fruit (Myrciaria cauliflora) and Its Biological Effects in Hypertensive Rats

Souza

Andrade

Jordão

et al. 2017

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Jabuticaba is an exotic fruit native to Brazil that has been arousing medicinal interest. Using chemical (HPLC-PDA, resonance mass spectra, and NMR), electroanalytical (differential pulse voltammetry, radical scavenging assay), and pharmacological (in vivo and in vitro) approaches, we have identified its bioactive compounds and hypotensive effects on hypertensive rats. The hydroalcoholic extract of jabuticaba (HEJ) presents a great quantity of phenolic compounds, and several molecules with hydroxyl groups present high efficiency as an antioxidant. The treatment with HEJ (100 and 300 mg/kg/day, for four weeks) presented hypotensive effects on L-NAME-induced hypertensive rats, possibly improving the nitric oxide bioavailability because of its high antioxidant potential. Furthermore, renal and cardiac hypertrophies were also attenuated after the HEJ treatment. Moreover, the vascular responses to contractile and dilating agonists were improved with the HEJ treatment, which is also able to induce nitric oxide production in endothelial cells.

show abstract

“…In our experiment, the blockade on NOS by L-NAME promoted a significant increase in gastric lesions and also reversed the gastroprotective action of X. americana aqueous extract, also indicating a possible contribution of this mediator. It should be noted that although the 70 mg/kg dose of L-NAME with a focus on gastroprotection mechanisms involving the role of nitric oxide as a mediator of gastroprotection has been obtained from studies in the literature [ 51 , 52 , 53 , 54 ], this same dose is also capable of increasing the blood pressure of rats [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

Contribution of Secondary Metabolites to the Gastroprotective Effect of Aqueous Extract of Ximenia americana L. (Olacaceae) Stem Bark in Rats

et al. 2018

View full text Add to dashboard Cite

Ximenia americana L. (Olacaceae) is used in ethnomedicine as cicatrizant and for the treatment of gastric disorders. This study identified the chemical constituents of the aqueous extract of X. americana (XaAE) and evaluated its antiulcerogenic activity. After lyophilization, XaAE was analyzed by liquid chromatography-mass spectrometry (LC-MS) and its antiulcerogenic effect was evaluated in acute gastric lesions induced by ethanol, acidified ethanol, and indomethacin. Antisecretory action, mucus production and the participation of sulfhydryl groups (–SH) and nitric oxide (NO) were also investigated. The chromatographic analysis identified procyanidins B and C and catechin/epicatechin as major compounds. Oral administration of XaAE (100, 200 and 400 mg/kg) inhibited the gastric lesions induced by ethanol (76.1%, 77.5% and 100%, respectively), acidified ethanol (44.9%, 80.6% and 94.9%, respectively) and indomethacin (56.4%, 52.7% and 64.9%, respectively). XaAE reduced gastric contents and acidity (51.4% and 67.7%, respectively) but did not alter the production of gastric mucus. The reduction of the -SH and NO groups promoted by N-ethylmaleimide (NEM) and Nω-nitro-l-arginine-methyl-ester (L-NAME) respectively, reduced the gastroprotective effect of XaAE. In conclusion, XaAE has gastroprotective activity mediated in part by -SH, NO and antisecretory activity. This antiulcer action was initially correlated to its major constituents, procyanidins B and C and catechin/epicatechin.

show abstract

Barnidipine ameliorates the vascular and renal injury in l-NAME-induced hypertensive rats

Cited by 16 publications

References 36 publications

Protective Effects of Ellagic Acid on Cardiovascular Injuries Caused by Hypertension in Rats

Protective Effects of Ellagic Acid on Cardiovascular Injuries Caused by Hypertension in Rats

Radical Scavenger Capacity of Jabuticaba Fruit (Myrciaria cauliflora) and Its Biological Effects in Hypertensive Rats

Contribution of Secondary Metabolites to the Gastroprotective Effect of Aqueous Extract of Ximenia americana L. (Olacaceae) Stem Bark in Rats

Contact Info

Product

Resources

About