Barrett's Esophagus at a Tertiary Care Center: Association of Age on Incidence and Prevalence of Dysplasia and Adenocarcinoma

Guardino, Jason M.; Khandwala, Farah; López, Rocío; Wachsberger, Don; Richter, Joel E.; Falk, Gary W.

doi:10.1111/j.1572-0241.2006.00736.x

Cited by 53 publications

(33 citation statements)

References 27 publications

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“…Finally, there is no data to support the use of transoral of symptoms, who are over the age of 50, male, and Caucasian. Th e diffi culty in risk stratifi cation is highlighted by the fact that 25 % of patients with Barrett ' s are women or under the age of 50 ( 177,178 ). Despite the well-identifi ed epidemiologic risk factors there is no clear profi le that mandates screening.…”

Section: Summary Of the Evidencementioning

confidence: 99%

Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease

Katz¹,

Gerson²,

Vela³

2013

American Journal of Gastroenterology

1,554

1,430

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Section: Summary Of the Evidencementioning

confidence: 99%

Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease

Katz¹,

Gerson²,

Vela³

2013

American Journal of Gastroenterology

1,554

1,430

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“…The limitations of this study include the retrospective nature of the analysis and the fact that the patient population comprises mostly of older men who are at increased risk of EE [16] and BE [17] . Therefore, these data might not be applicable to populations who have higher preponderance of women and relatively younger patients.…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Barrett’s esophagus in patients with moderate to severe erosive esophagitis

Gilani¹,

Gerkin²,

Ramirez³

et al. 2008

WJG

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AIM:To investigate the proportion of patients with moderate-severe erosive esophagitis (EE) who will have Barrett's esophagus (BE) after healing of inflammation. METHODS: Patients with EE of Los Angeles (LA) class B, C and D who underwent follow-up endoscopy documenting complete mucosal healing. RESULTS: A total of 86/169 patients were suspected of having BE (38 before healing and 48 after healing of EE) and, 46/86 eventually had the histological confirmation. At index esophago-gastro-duodenoscopy (EGD), BE was suspected in 38/169 (22%), and ultimately, histologically confirmed in 20 of these. In 11 patients where biopsies were performed in the presence of inflammation, BE was detected in 2 and missed in 5 (including 2 dysplasias). In 131/169 patients (77.5%), BE was not suspected at index EGD. After healing of EE though, 48 patients had suspicion of BE who underwent biopsies, and in 26 of these histology was positive for BE. The length of inflammation had a linear correlation with the length of BE (P = 0.01). Out of multiple variables to predict BE, only the suspicion at index endoscopy was statistically significant (P = 0.01). CONCLUSION: B E wa s s e e n i n 4 6 / 1 6 9 ( 2 7 % ) patients with EE of LA class B, C and D. The length of EE can predict the length of underlying BE segment.Even when suspected, BE and associated dysplasia can be missed in the presence of inflammation; therefore, repeat evaluation should be considered after complete healing of esophagitis.

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“…In his study, A total of 492 cases of BE were identified in 21, 899 first endoscopies, then the prevalence and age, gender distribution of BE was successfully described, and the very similar demographics of intestinal metaplasia and intestinal metaplasia plus BE was found, which suggested they may be two consecutive stages in the same metaplastic process (van Blankenstein et al, 2005). Success of van Blankenstein and several other studies (Guardino et al, 2006;Jung et al, 2011) demonstrated the effectiveness and efficiency of primary endoscopy patients but not the large-scale population in assessing the prevalence and distribution of esophagus diseases.…”

Section: Introductionmentioning

confidence: 91%

Prevalence and Age, Gender and Geographical Area Distribution of Esophageal Squamous Cell Carcinomas in North China from 1985 to 2006

Feng¹,

Yang²,

Gao³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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2 (95%CI, 1.2-1.3). The prevalence in rural areas was higher than in urban areas (p<0.01), resulting in an overall rural:urban OR of 2.6 (95%CI, 2.4-2.9). The rural:urban ORs and the 95% CI increased continuously from 2.6, 2.3-3.0 to 2.7, 2.2-3.3, respectively, for 4 consecutive periods during the 22-yr study period. Moreover, the median age of onset among females was higher than that among males (p<0.01). For both sexes and in both areas, the prevalence rates declined and the median age of onset rose for 4 consecutive periods in the 22-yrs time frame (p<0.01). Conculsions: These data reveal the epidemiological profile of ESCC in the area of North China, and suggest that urban areas and rural people account for a growing proportion of the ESCC patients although the prevalence of ESCC significantly declined and the median age-of-onset postponed over the 22-yrs period. Moreover, the prevalence status of ESCC in rural areas also underlines the need for public health initiatives aimed at reducing risk factors of this fatal disease.

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Barrett's Esophagus at a Tertiary Care Center: Association of Age on Incidence and Prevalence of Dysplasia and Adenocarcinoma

Cited by 53 publications

References 27 publications

Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease

Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease

Prevalence of Barrett’s esophagus in patients with moderate to severe erosive esophagitis

Prevalence and Age, Gender and Geographical Area Distribution of Esophageal Squamous Cell Carcinomas in North China from 1985 to 2006

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