Barrettʼs oesophagus

Bartelsman, J F W M; Hameeteman, W.; Tytgat, G. N. J.

doi:10.1097/00008469-199206000-00008

Cited by 40 publications

(19 citation statements)

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“…Patients with BE have a greatly increased risk of esophageal dysplasia and adenocarcinoma [2,3]. From 6% to 12% of patients with gastroesophageal reflux disease develop BE [4], and those with BE develop esophageal adenocarcinoma at a rate of ∼1 case per 100 patient-years [4,5]. Rates of carcinoma of the mid and distal stomach are decreasing; conversely, adenocarcinoma of the esophagus has been steadily increasing in Western countries over the past 3 decades [6,7], and it is now the seventh most common cause of cancerrelated death in the United Kingdom.…”

mentioning

confidence: 99%

Microbial Colonization of the Upper Gastrointestinal Tract in Patients with Barrett's Esophagus

Macfarlane

Furrie

Macfarlane

et al. 2007

Clinical Infectious Diseases

155

126

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Background. Barrett's esophagus (BE) is a complication of chronic gastroesophageal reflux disease, in which patients are at greatly increased risk of esophageal dysplasia and adenocarcinoma. Over the past 2 decades, there has been an increase in the incidence of both BE and adenocarcinoma; however, the involvement of microorganisms in BE is uncertain. The aim of this study was to characterize microbial communities in esophageal aspirate specimens and on distal esophageal mucosal samples from patients with BE.Methods. Biopsy and aspirate specimens were obtained by endoscopic examination from 7 patients with BE and 7 control subjects without BE. Samples were cultured under aerobic, anaerobic, and microaerophilic conditions for yeasts and bacteria, including Helicobacter pylori. Bacterial isolates were identified by 16S ribosomal RNA gene sequencing. Fluorescence microscopic examination was also used to determine the spatial localization of these organisms on mucosal surfaces. Significant colonization was detected in 6 patients with BE and in 4 control subjects.Results. Overall, 46 bacterial species belonging to 16 genera were detected, with 10 species being common in both groups. Both aspirate and biopsy samples from patients with BE contained complex populations of bacteria. Uniquely, high levels of Campylobacter species (Campylobacter concisus and Campylobacter rectus), which have been linked to enteritis, periodontal infections, and tumor formation in animals, were found in 4 (57%) of 7 patients with BE but in none of the control subjects. Microscopic examination revealed that bacteria on mucosal biofilms often occurred in microcolonies.Conclusions. The occurrence of nitrate-reducing Campylobacter species in patients with BE may suggest that there is a link in either the initiation, maintenance, or exacerbation of disease processes leading to adenocarcinoma formation.

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mentioning

confidence: 99%

Microbial Colonization of the Upper Gastrointestinal Tract in Patients with Barrett's Esophagus

Macfarlane

Furrie

Macfarlane

et al. 2007

Clinical Infectious Diseases

155

126

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“…Furthermore, a previous study from the UK National Barrett's Oesophagus Registry (UKBOR) has not only confirmed this, but has demonstrated a similar neoplastic risk in patients with columnar metaplasia with and without demonstrable intestinal metaplasia (Vaezi et al 1996;Lieberman et al 1997;Locke et 2003;Smpliner et al 2002;Watson et al 2005;Shepherd et al 2003;. The relative risk of adenocarcinoma development in patients with columnar-lined esophagus has been estimated at 5-125 fold higher than of control populations (Van der Veen et al 1989;Bartelsman et al 1992;Iftikar et al 1992;Solaymani-Dodaran et 2004;Anderson et al 2003) with the overall annual adenocarcinoma risk in columnar-lined esophagus at 0.69% (range 0-3.6%) per annum .…”

Section: Barrett's Esophagusmentioning

confidence: 87%

Surgical Treatment of Gastroesophageal Reflux Disease

Tosato¹,

Marano²,

Mattacchione³

et al. 2011

Advances in Endoscopic Surgery

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“…This study suggested that the incidence of adenocarcinoma in BE is lower than previously believed. Of 115 patients with BE in Amsterdam [39], dysplasia was found in 46%; 14% had HGD. Weston et al [40] followed 108 newly diagnosed patients with BE for 12-101 months; 5 developed HGD and 5 developed adenocarcinomas.…”

Section: Association Of Be In Esophageal Adenocarcinomamentioning

confidence: 99%

Epidemiology and Significance of Barrett’s Esophagus

DeVault¹

2000

Dig Dis

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Barrett’s esophagus (BE) is of interest because of its recognized association with esophageal adenocarcinoma. While BE develops in a minority of patients with gastroesophageal reflux disease, its diagnosis has markedly increased over the last 30 years. Although a concurrent increase in the number of endoscopies performed annually has improved the ability to diagnose BE, the increase in prevalence appears to be a true finding. Conflicting data in the literature confound an accurate assessment of the risk for adenocarcinoma in patients with BE. Certain factors associated with BE also hold for esophageal adenocarcinoma: greater severity of reflux symptoms, specific pattern of symptoms (particularly nocturnal), longer duration of symptoms, white race, and male gender. One report has suggested a 45-fold increase in cancer risk for patients with frequent, severe and long-standing heartburn symptoms. New cases of esophageal adenocarcinoma are also increasing, especially in white males, with over 6,000 new cases diagnosed in 1995. BE can progress to esophageal dysplasia and adenocarcinoma; hence, early diagnosis and surveillance of BE and treatment of high-grade dysplasia leads to improved survival. The reported risk of developing cancer in BE ranges from 0.4 to 1.9%/year of follow-up. Most recent studies have tended to report rates of 0.5%/year or lower. Despite these data and concerns, at least two actuarial studies have suggested that the risk of death in patients with BE does not differ from that of a control population. This review of the literature focuses on the epidemiology of BE and the associated incidence of its sequelae.

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Barrettʼs oesophagus

Cited by 40 publications

References 0 publications

Microbial Colonization of the Upper Gastrointestinal Tract in Patients with Barrett's Esophagus

Microbial Colonization of the Upper Gastrointestinal Tract in Patients with Barrett's Esophagus

Surgical Treatment of Gastroesophageal Reflux Disease

Epidemiology and Significance of Barrett’s Esophagus

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