Barriers to implementing sustainable national newborn screening in developing health systems☆

Therrell, Bradford L.; Padilla, Carmencita D.

doi:10.1016/j.ijpam.2014.10.004

Cited by 29 publications

(41 citation statements)

References 33 publications

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“…The challenges noted and their potential solution are similar to those experienced in most developing programs, only they encompass a much larger screening population. 169,170 Among the countries that lack total NBS coverage, the obstacles are usually the same: poor economies, insufficient Table 6 -Program demographics and screened conditions in Asia Pacific newborn screening programs. S E M I N A R S I N P E R I N A T O L O G Y 3 9 ( 2 0 1 5 ) 1 7 1 -1 8 7 health education, lack of government support, early hospital discharge, and large numbers of out-of-hospital births.…”

Section: Asia Pacificmentioning

confidence: 99%

Current status of newborn screening worldwide: 2015

Therrell

Padilla

Loeber³

et al. 2015

Seminars in Perinatology

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418

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Section: Asia Pacificmentioning

confidence: 99%

Current status of newborn screening worldwide: 2015

Therrell

Padilla

Loeber³

et al. 2015

Seminars in Perinatology

Self Cite

482

418

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“…Besides this complication, the participated institutions involved in the TMS screening also face challenges like limited governmental recognition and support, insufficient professional and public education, decentralized administration, early hospital discharge, etc. [3,24,25], making implementation of the current TMS screening scheme less efficient and beneficial to health economics. Because of incomplete recall and insufficient confirmation or diagnosis, we utilized a customized TNGS assay to investigate residual DBS samples of CDI cases from the …”

Section: The Current Situation Of Tms Screening In Chinamentioning

confidence: 99%

Applying targeted next generation sequencing to dried blood spot specimens from suspicious cases identified by tandem mass spectrometry-based newborn screening

Qian

Wang

Liu

et al. 2017

Journal of Pediatric Endocrinology and Metabolism

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Background: Tandem mass spectrometry (TMS)-based newborn screening has been proven successful as one of the public healthcare programs, although the practicability has not yet been specifically addressed. Methods: Sixty residual dried blood spot (DBS) specimens from confirmation/diagnosis-insufficient cases discovered by TMS screening were analyzed by targeted next generation sequencing (TNGS) assay. Results: In total, 26, 11, 9, and 14 cases were diagnosed as positive, high risk, low risk, and negative, respectively. Conclusions: Applying the DBS-based TNGS assay for the accurate and rapid diagnosis of inborn errors of metabolism (IEMs) is feasible, competent, and advantageous, enabling a simplified TMS screening-based, TNGS assay-integrated newborn screening scheme highlighting an efficient, executable, and one-step screening-to-diagnosis workflow.

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“…Dukungan penuh pemerintah dengan program lain yang terintegrasi seperti imunisasi bayi baru lahir mungkin dapat mendukung ketersediaan logistik skrining. 8,9 Pada setiap fasyankes pelaksana program SHK, paling tidak ada satu orang yang pernah sekali atau beberapa kali ikut pelatihan (praktek dengan phantom) dan atau sosialisasi terkait cara pengambilan spesimen SHK. Namun, beberapa tenaga kesehatan terkadang mengalami kegagalan memenuhi bulatan kertas 10 Ketentuan pihak BPJS untuk dapat pulang segera pasca melahirkan mengakibatkan persentase spesimen yang diambil terlalu dini pada kelompok dana pemerintah lebih besar dibandingkan kelompok dana mandiri.…”

Section: Ketepatan Waktu Pengiriman Spesimenunclassified

“…Selain itu, administrasi program yang bagus akan menjamin keberhasilan program. 8,13 Hasil tes yang terlambat diketahui mengakibatkan pasien suspect HK juga terlambat mengikuti tes konfirmasi yaitu sekitar di atas usia 18 hari, bahkan di atas 1 bulan. Masyarakat yang awam tentang SHK juga dapat menjadi alasan tes konfirmasi yang terlambat sebagaimana menurut Dilli dkk 14 bahwa rakyat Turki yang tidak datang untuk mengikuti tes kedua program SHK karena kepercayaan kuno, alasan sosial ekonomi, dan kesulitan dalam komunikasi/transportasi.…”

Section: Ketepatan Waktu Pengiriman Spesimenunclassified

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Ketepatan Waktu Pelayanan Skrining Hipotiroidism Kongenital di Yogyakarta

Anggraini¹,

Patria

Julia

2017

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Latar belakang. Deteksi dan pengobatan dini hipotiroid kongenital dapat mengurangi risiko terjadinya disabilitas intelektual, sehingga ketepatan waktu pelayanan merupakan kunci keberhasilan program skrining hipotiroid kongenital (SHK) pada bayi baru lahir. Tujuan. Mengevaluasi pelaksanaan program SHK pada bayi baru lahir di Yogyakarta tahun 2013-2015. Metode. Data ketepatan waktu pengambilan, pengiriman spesimen ke laboratorium dan data umpan balik hasil skrining dikumpulkan melalui catatan dan pelaporan program di fasilitas pelayanan kesehatan, Dinas Kesehatan Provinsi DIY dan Laboratorium Patologi Klinik FK UGM. Hasil. Persentase pengambilan spesimen yang tidak tepat waktu pada kelompok dana pemerintah (25%-32%) lebih besar daripada kelompok dana mandiri (11%-15%). Persentase pengiriman spesimen ke laboratorium yang tidak tepat waktu dari kelompok dana pemerintah (38%-45%) lebih besar daripada kelompok dana mandiri (7%-11%). Hasil tes TSH tinggi diterima oleh Dinas Kesehatan Provinsi DIY/Patologi Klinik UGM ketika usia bayi sudah lebih dari 2 minggu, sedangkan hasil tes yang tidak terbaca diterima ketika usia bayi 22-59 hari. Timeliness of Screening for Congenital Hypothyroidism in YogyakartaRini Anggraini, * Suryono Yudha Patria, ** Madarina Julia ** Background. Early detection and management of congenital hypothyroidism will minimize risk for intellectual disability. Hence, timing is the key success for its screening in newborns.Objective. The study aimed to evaluate the implementation of newborn screening for congenital hypothyroidism in Yogyakarta year 2013-2015.Methods. Data on timeliness of blood sampling, sample delivery and delivery of results from the assigned laboratory were collected from records and reports of the health service facilities, Provincial Health Office and Clinical Pathology Laboratory of the Medical Faculty UGM.Result. The percentage of not-timely collected specimens was higher in the government fund group (25%-32%) vs. the private fund group (11%-15%). The percentage of specimens not-timely delivered to the assigned laboratory was higher in the private fund group (38%-45%) vs. government fund group (7%-11%). High TSH test results were received by Provincial Health Office/ Clinical Pathology Laboratory when the babies were more than 2 weeks old. Some tests were identified to be unreadable when babies were already between 22-59 days old. Conclusion. After 10 years implementation, the coverage of the newborn screening is 10%. The results of the screening were, mostly, not-timely received. The system was not efficient. Sari Pediatri 2017;18(6):436-42

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Barriers to implementing sustainable national newborn screening in developing health systems☆

Cited by 29 publications

References 33 publications

Current status of newborn screening worldwide: 2015

Current status of newborn screening worldwide: 2015

Applying targeted next generation sequencing to dried blood spot specimens from suspicious cases identified by tandem mass spectrometry-based newborn screening

Ketepatan Waktu Pelayanan Skrining Hipotiroidism Kongenital di Yogyakarta

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