Bartonella diversity and zoonotic potential in indigenous Tete Veld rats (Aethomys ineptus) from South Africa

Hatyoka, Luiza M.; Brettschneider, Helene; Bennett, Nigel C.; Kleynhans, Dewald J.; Muteka, Sachariah P.; Bastos, Armanda D.S.

doi:10.1016/j.meegid.2019.04.012

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…Among all known reservoir hosts of Bartonella species, rodents are considered the primary host, and Bartonella spp. in rodents have been reported in Asia (Li et al, 2015;Saengsawang et al, 2021;Liu et al, 2022), Africa (Hatyoka et al, 2019), Europe (Divari et al, 2020;Szewczyk et al, 2021), Americas (De Sousa et al, 2018;Müller et al, 2020), and Australia (Dybing et al, 2016;Egan et al, 2021). Approximately 90 species of rodents are known to be associated with more than 22 different species of Bartonella, ten of which have been confirmed to cause human infection (Daly et al, 1993;Welch et al, 1999;Birtles et al, 2002;Kosoy et al, 2003Kosoy et al, , 2008Kosoy et al, , 2010Lin et al, 2008;Kandelaki et al, 2016;Vayssier-Taussat et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and Genetic Diversity of Bartonella in Rodents in Urban Areas of Guangzhou, Southern China

et al. 2022

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Bartonella spp. are gram-negative bacteria that can infect a wide spectrum of mammals. Rodents are considered to be the natural reservoir of many Bartonella species that are transmitted by various blood-sucking arthropods. The close contact between rodents and humans in urban areas increased the chance of transmitting rodent-borne Bartonella to humans. Investigation of the epidemiological characteristics of Bartonella infection in rodents is of great significance for the prevention and control of human Bartonellosis. In this study, rodents were captured to monitor the prevalence of Bartonella in urban areas of Guangzhou city. Six official or candidate species of Bartonella, including two confirmed zoonotic species, were detected with an overall prevalence of 6.4% in rodents captured herein. In addition, Rattus norvegicus was the predominant host species for Bartonella infection, and B. queenslandensis was the dominant species circulating in rodents in these areas. These results provide insights into the prevalence and genetic diversity of Bartonella species circulating in rodents in the urban areas of Guangzhou, and also urged the surveillance of rodent-associated Bartonella species in these areas.

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Section: Introductionmentioning

confidence: 99%

Epidemiology and Genetic Diversity of Bartonella in Rodents in Urban Areas of Guangzhou, Southern China

et al. 2022

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Prevalence and genetic diversity of Bartonella spp. in wild small mammals from South Africa

Mhlanga,

Chitanga,

Matthee

et al. 2024

Appl Environ Microbiol

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Bartonella spp. are intracellular bacteria associated with several re-emerging human diseases. Small mammals play a significant role in the maintenance and spread of Bartonella spp. Despite the high small mammal biodiversity in South Africa, there is limited epidemiological information regarding Bartonella spp. in these mammals. The main aim of this study was to determine the prevalence and genetic diversity of Bartonella spp. from wild small mammals from 15 localities in 8 provinces of South Africa. Small mammals ( n = 183) were trapped in the Eastern Cape, Free State, Gauteng, Limpopo, Mpumalanga, Northern Cape, North West, and Western Cape provinces of South Africa between 2010 and 2018. Heart, kidney, liver, lung, and spleen were harvested for Bartonella DNA screening, and prevalence was determined based on the PCR amplification of partial fragments of the 16S–23S rRNA intergenic spacer (ITS) region, gltA, and rpoB genes. Bartonella DNA was detected in Aethomys chrysophilus , Aethomys ineptus , Gerbillurus spp., Lemniscomys rosalia , Mastomys coucha , Micaelamys namaquensis , Rhabdomys pumilio, and Thallomys paedulcus . An overall prevalence of 16.9% (31/183, 95% CI: 12.2%–23%) was observed. Bartonella elizabethae , Bartonella grahamii, and Bartonella tribocorum were the zoonotic species identified, while the remaining sequences were aligned to uncultured Bartonella spp. with unknown zoonotic potential. Phylogenetic analyses confirmed five distinct Bartonella lineages (I–V), with lineage IV displaying strong M. coucha host specificity. Our results confirm that South African wild small mammals are natural reservoirs of a diverse assemblage of Bartonella spp., including some zoonotic species with high genetic diversity, although prevalence was relatively low. IMPORTANCE Small mammals play a significant role in the maintenance and spread of zoonotic pathogens such as Bartonella spp. Despite the high small mammal biodiversity in southern Africa including South Africa, there is limited epidemiological information regarding Bartonella spp. in these mammals across the country. Results from our study showed the liver and spleen had the highest positive cases for Bartonella spp. DNA among the tested organs. Bartonella elizabethae , B. grahamii, and B. tribocorum were the three zoonotic species identified and five distinct Bartonella lineages (I–V) were confirmed through phylogenetic analyses. To the best of our knowledge, this study presents the first extensive nuclear diversity investigation of Bartonella spp. in South African small mammals in South Africa.

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Emerging rodent-associated Bartonella: a threat for human health?

Krügel,

Król,

Kempf

et al. 2022

Parasites Vectors

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Background Species of the genus Bartonella are facultative intracellular alphaproteobacteria with zoonotic potential. Bartonella infections in humans range from mild with unspecific symptoms to life threatening, and can be transmitted via arthropod vectors or through direct contact with infected hosts, although the latter mode of transmission is rare. Among the small mammals that harbour Bartonella spp., rodents are the most speciose group and harbour the highest diversity of these parasites. Human–rodent interactions are not unlikely as many rodent species live in proximity to humans. However, a surprisingly low number of clinical cases of bartonellosis related to rodent-associated Bartonella spp. have thus far been recorded in humans. Methods The main purpose of this review is to determine explanatory factors for this unexpected finding, by taking a closer look at published clinical cases of bartonellosis connected with rodent-associated Bartonella species, some of which have been newly described in recent years. Thus, another focus of this review are these recently proposed species. Conclusions Worldwide, only 24 cases of bartonellosis caused by rodent-associated bartonellae have been reported in humans. Possible reasons for this low number of cases in comparison to the high prevalences of Bartonella in small mammal species are (i) a lack of awareness amongst physicians of Bartonella infections in humans in general, and especially those caused by rodent-associated bartonellae; and (ii) a frequent lack of the sophisticated equipment required for the confirmation of Bartonella infections in laboratories that undertake routine diagnostic testing. As regards recently described Bartonella spp., there are presently 14 rodent-associated Candidatus taxa. In contrast to species which have been taxonomically classified, there is no official process for the review of proposed Candidatus species and their names before they are published. This had led to the use of malformed names that are not based on the International Code of Nomenclature of Prokaryotes. Researchers are thus encouraged to propose Candidatus names to the International Committee on Systematics of Prokaryotes for approval before publishing them, and only to propose new species of Bartonella when the relevant datasets allow them to be clearly differentiated from known species and subspecies. Graphical Abstract

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Bartonella diversity and zoonotic potential in indigenous Tete Veld rats (Aethomys ineptus) from South Africa

Cited by 3 publications

References 31 publications

Epidemiology and Genetic Diversity of Bartonella in Rodents in Urban Areas of Guangzhou, Southern China

Epidemiology and Genetic Diversity of Bartonella in Rodents in Urban Areas of Guangzhou, Southern China

Prevalence and genetic diversity of Bartonella spp. in wild small mammals from South Africa

Emerging rodent-associated Bartonella: a threat for human health?

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