1980
DOI: 10.1042/cs0580385
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Basal Activity of the Natriuretic Factor Extracted from the Rat Kidney as a Function of the Diet and its Role in the Regulation of the Acute Sodium Balance

Abstract: 1. The effect of the sodium content of the diet on the natriuretic activity of an extract from the kidneys was studied in non-expanded and volume-expanded rats. 2. The kidney tissue was homogenized and the supernatant fractionated by gel filtration of Sephadex G-25. A single low-molecular-weight fraction eluted after the salt possessed the natriuretic activity and was tested on a rat bioassay. 3. The natriuretic activity of the fraction obtained from the kidneys of non-expanded rats was related to the sodium i… Show more

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Cited by 14 publications
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“…An endogenous Na + /K + -ATPase inhibitor is defined as a substance, which should be specific for and have a high affinity for Na + /K + -ATPase (Haupert 1988). There are several reports showing the presence of Na + /K + -ATPase inhibitor from different tissues (Gonick and Saldanha 1975;Louis and Favre 1980;Haupert and Sancho 1979), plasma (Buckalew and Nelson 1974;Hamlyn et al 1982) and urine (Clarkson et al 1979;Cloix et al 1985). These compounds possess wide range of molecular masses.…”
Section: Discussionmentioning
confidence: 98%
“…An endogenous Na + /K + -ATPase inhibitor is defined as a substance, which should be specific for and have a high affinity for Na + /K + -ATPase (Haupert 1988). There are several reports showing the presence of Na + /K + -ATPase inhibitor from different tissues (Gonick and Saldanha 1975;Louis and Favre 1980;Haupert and Sancho 1979), plasma (Buckalew and Nelson 1974;Hamlyn et al 1982) and urine (Clarkson et al 1979;Cloix et al 1985). These compounds possess wide range of molecular masses.…”
Section: Discussionmentioning
confidence: 98%