Basal and reactive cortisol: A systematic literature review of offspring of parents with depressive and bipolar disorders

Klimes‐Dougan, Bonnie; Papke, Victoria; Carosella, Katherine A.; Wiglesworth, Andrea; Mirza, Salahudeen; Espensen-Sturges, Tori; Meester, Christina

doi:10.1016/j.neubiorev.2022.104528

Cited by 20 publications

(11 citation statements)

References 164 publications

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“…Third, we focused exclusively on psychophysiological and neural indices of emotional reactivity and regulation as opposed to self‐report or behavioral indicators, as these have been reviewed previously. Similarly, glucocorticoid cortisol and other steroid hormones were excluded from the current review as these units reflect stress reactivity more broadly versus emotion specific processes and a recent comprehensive review was conducted on this topic (Klimes‐Dougan et al., 2022). Future studies may benefit from evaluating differences in the strength of association between varying emotion processing measures (self‐report to neural) and maternal MDD history to determine which markers should be prioritized for detection and prevention efforts.…”

Section: Discussionmentioning

confidence: 99%

Annual Research Review: Emotion processing in offspring of mothers with depression diagnoses – a systematic review of neural and physiological research

Burkhouse

Kujawa

2022

Child Psychology Psychiatry

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Background Theories of the intergenerational transmission of depression emphasize alterations in emotion processing among offspring of depressed mothers as a key risk mechanism, raising questions about biological processes contributing to these alterations. The objective of this systematic annual research review was to examine and integrate studies of the associations between maternal depression diagnoses and offspring's emotion processing from birth through adolescence across biological measures including autonomic psychophysiology, electroencephalography (EEG), magnetoencephalography (MEG), event‐related potentials (ERP), and structural and functional magnetic resonance imaging (MRI). Methods The review was conducted in accordance with the PRISMA 2020 standards. A systematic search was conducted in PsycInfo and PubMed in 2022 for studies that included, 1) mothers with and without DSM‐defined depressive disorders assessed via a clinical or diagnostic interview, and 2) measures of offspring emotion processing assessed at the psychophysiological or neural level between birth and 18 years of age. Results Findings from 64 studies indicated that young offspring of mothers with depression histories exhibit heightened corticolimbic activation to negative emotional stimuli, reduced left frontal brain activation, and reduced ERP and mesocorticolimbic responses to reward cues compared to offspring of never‐depressed mothers. Further, activation of resting‐state networks involved in affective processing differentiate offspring of depressed relative to nondepressed mothers. Some of these alterations were only apparent among youth of depressed mothers exposed to negative environmental contexts or exhibiting current emotional problems. Further, some of these patterns were observable in infancy, reflecting very early emerging vulnerabilities. Conclusions This systematic review provides evidence that maternal depression is associated with alterations in emotion processing across several biological units of analysis in offspring. We present a preliminary conceptual model of the role of deficient emotion processing in pathways from maternal depression to offspring psychopathology and discuss future research avenues addressing limitations of the existing research and clinical implications.

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Section: Discussionmentioning

confidence: 99%

Annual Research Review: Emotion processing in offspring of mothers with depression diagnoses – a systematic review of neural and physiological research

Burkhouse

Kujawa

2022

Child Psychology Psychiatry

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“…Like circadian dysfunction, cortisol secretion is significantly higher in BD patients compared to controls, independent of the clinical BD phase [41,42 ▪▪ ], suggesting that hypercortisolism and neurotoxic effects of cortisol may be central to the pathogenesis of depressive mood and cognitive impairment. Meanwhile, manic episodes are preceded by increased cortisol and adrenocorticotropic hormone concentrations.…”

Section: Stress and Circadian Rhythm In Bipolar Disordermentioning

confidence: 99%

Advances in the pathophysiology of bipolar disorder

Wartchow

Cordeiro

Scaini

2022

Current Opinion in Psychiatry

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Purpose of reviewDue to bipolar disorder clinical heterogeneity, a plethora of studies have provided new genetic, epigenetic, molecular, and cellular findings associated with its pathophysiology. Recent findingsGenome-wide association studies and epigenetic evidence points to genotype--phenotype interactions associated with inflammation, oxidative stress, abnormalities in signaling pathways, hypothalamic-pituitary--adrenal axis, and circadian rhythm linked to mitochondrial dysfunction in bipolar disorder. Although the literature is constantly increasing, most of the genetic variants proposed as biomarkers remain to be validated by independent groups and use bigger samples and longitudinal approaches to enhance their power and predictive ability.

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“…Accordingly, Meewisse et al (45) (46,47). Other studies, in contrast, provided evidence for the opposite effect direction: positive affect as well as mental symptoms longitudinally predicted basal cortisol changes (32,33,48,49). In a recent review, Klimes-Dougan et al (50) summarized the transgenerational effects of maternal depressive and bipolar disorders on the cortisol concentrations of the offspring.…”

Section: Introductionmentioning

confidence: 99%

Association between childhood maltreatment and adult cortisol concentrations mediated through subjective health complaints

Klinger-König

Hannemann²,

Friedrich³

et al. 2023

Front. Epidemiol.

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BackgroundLower cortisol concentrations in adulthood were repeatedly associated with more severe childhood maltreatment. Additionally, childhood maltreatment was reported to promote health risk behavior, such as smoking or alcohol consumption, and to increase the risk of mental and somatic diseases during adulthood, such as major depressive disorders or obesity. The present study investigated if health risk behavior and disease symptoms in adults mediate the associations between past childhood maltreatment and present basal serum cortisol concentrations.MethodsData from two independent adult cohorts of the general population-based Study of Health in Pomerania (SHIP-TREND-0: N = 3,517; SHIP-START-2: N = 1,640) was used. Childhood maltreatment was assessed via the Childhood Trauma Questionnaire (CTQ). Cortisol concentrations were measured in single-point serum samples. Health risk behavior and mental and physical symptoms were used as mediators. Mediation analyses were calculated separately for both cohorts; results were integrated via meta-analyses.ResultsIn mediator-separated analyses, associations between childhood maltreatment and basal serum cortisol concentrations were partly mediated by depressive symptoms (BDI-II: βindirect effect = -.011, pFDR = .017, 21.0% mediated) and subjective somatic health complaints (somatic complaints: βindirect effect = -.010, pFDR = .005, 19.4% mediated). In the second step, both mediators were simultaneously integrated into one mediation model. The model replicated the mediation effects of the subjective somatic health complaints (whole model: βindirect effect = -.014, p = .001, 27.6% mediated; BDI-II: βindirect effect = -.006, p = .163, 11.4% mediated, somatic complaints: βindirect effect = -.020, p = .020, 15.5% mediated).ConclusionThe results support the hypothesis that the long-lasting effects of childhood maltreatment on the stress response system are partly mediated through self-perceived disease symptoms. However, no mediation was found for health risk behavior or physically measured mediators. Mediation models with multiple simultaneous mediators pointed to a relevant overlap between the potential mediators. This overlap should be focused on in future studies.

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Basal and reactive cortisol: A systematic literature review of offspring of parents with depressive and bipolar disorders

Cited by 20 publications

References 164 publications

Annual Research Review: Emotion processing in offspring of mothers with depression diagnoses – a systematic review of neural and physiological research

Annual Research Review: Emotion processing in offspring of mothers with depression diagnoses – a systematic review of neural and physiological research

Advances in the pathophysiology of bipolar disorder

Association between childhood maltreatment and adult cortisol concentrations mediated through subjective health complaints

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