Basal and Stimulated Serum Growth Hormone Concentrations in Inflammatory Bowel Disease

Tenore, Alfred; Berman, Wallace F.; Parks, John S.; Bongiovanni, Alfred M.

doi:10.1210/jcem-44-4-622

Cited by 84 publications

(44 citation statements)

References 11 publications

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“…Growth failure and catabolism are serious clinical problems in children and adult patients with inflammatory bowel disease (IBD) [1] and have been linked to changes in the growth hormone (GH)/insulin-like growth factor I (IGF-I) axis [2]. Abnormal growth seems to be more frequent in Crohn’s disease (CD) than ulcerative colitis (UC) [3]; however, the precise mechanism is unknown.…”

Section: Introductionmentioning

confidence: 99%

The Insulin-Like Growth Factor System and Markers of Inflammation in Adult Patients with Inflammatory Bowel Disease

Eivindson¹,

Nielsen

Grønbæk³

et al. 2005

Horm Res Paediatr

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Background and Objectives:Catabolism and growth impairment are well-known complications of inflammatory bowel disease (IBD). Recent studies have demonstrated significant changes in the IGF system in IBD patients. The aim of the present study was to investigate correlations between the IGF system and markers of inflammation in IBD. Methods:A cross-sectional study comprising 99 IBD patients (Crohn’s disease (CD, n = 50) and ulcerative colitis (UC, n = 49)). Correlations between markers of inflammation and IGF-I, IGF-II and IGFBP-3 were examined in CD and UC patients in remission and relapse. The patients were clinically scored using Crohn’s Disease Activity Index (CDAI) for CD patients and Activity Index (AI) for UC patients. Results: In the UC group we found correlations between IGF-I and CRP (r_s = Spearman’s rho) (r_s = –0.40, p < 0.01) and albumin (r_s = 0.46, p < 0.001), IGFBP-3 and albumin (r_s = 0.36, p < 0.01) and AI score (r_s = –0.31, p < 0.05). IGF-II correlated with CRP (r_s = –0.42, p < 0.01), IL-6 (r_s = –0.65, p < 0.001), albumin (r_s = 0.41, p < 0.01), AI score (r_s = –0.30, p < 0.05) and orosomucoid (r_s = –0.47, p < 0.001). In the CD group we found correlations between IGF-I and CRP (r_s = –0.40, p < 0.05), and albumin (r_s = –0.46, p < 0.01), IGFBP-3 and albumin (r = 0.36, p < 0.01). IGF-II correlated with IL-6 (r_s = –0.65, p < 0.001), albumin (r_s = 0.41, p < 0.01), CDAI score (r_s = –0.30, p < 0.05) and orosomucoid (r_s = –0.47, p < 0.001). Conclusions: IGF-I, IGF-II and IGFBP-3 are correlated to albumin and IGF-I and IGF-II are correlated to CRP in IBD patients. Further, IGF-II is correlated to IL-6 in IBD patients. This may suggest a correlation between inflammation and the IGF system with involvement in muscle and bone catabolism in IBD.

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Section: Introductionmentioning

confidence: 99%

The Insulin-Like Growth Factor System and Markers of Inflammation in Adult Patients with Inflammatory Bowel Disease

Eivindson¹,

Nielsen

Grønbæk³

et al. 2005

Horm Res Paediatr

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“…In patients with cystic fibrosis, GH production appears to be substantially normal (9), whereas circulating levels of IGF-I are reduced (10). Also in patients with Crohn's disease, in which the production of IL-6 by inflamed mucosal tissue and the correlation between IL-6 levels and disease activity are well documented (11), circulating levels of IGF-I are decreased (12), whereas GH production is normal (13,14).…”

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confidence: 99%

Effect of IL-6 on IGF Binding Protein-3: A Study in IL-6 Transgenic Mice and in Patients with Systemic Juvenile Idiopathic Arthritis

Benedetti¹,

Meazza²,

Oliveri³

et al. 2001

Endocrinology

127

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Stunted growth is a common complication of childhood diseases characterized by chronic inflammation or infections.We previously demonstrated that NSE/hIL-6 transgenic mice, overexpressing the inflammatory cytokine IL-6 since early phase of life, showed a marked growth defect associated with decreased IGF-I levels, suggesting that IL-6 is one of the factors involved in stunted growth complicating chronic inflammation in childhood. Here we show that NSE/hIL-6 mice have normal liver IGF-I production, decreased levels of IGF bind-

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“…The mechanism of linear growth inhibition by GC has not been defined. The findings regarding the effects of GC on GH secretion are controversial [4, 5, 6, 7, 8]. It appears that GC may affect not so much the level of GH secretion, but rather the nyctohemeral GH secretion profile, resulting in delayed and attenuated nocturnal GH secretion peaks [9].…”

Section: Discussionmentioning

confidence: 99%

Treatment of Juvenile Rheumatoid Arthritis with Growth Hormone

2000

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Severe growth retardation and profoundly altered body composition are observed in children with juvenile chronic arthritis receiving glucocorticoids. This study assessed the effects of growth hormone (GH) on height velocity, body composition and bone density. Fourteen patients were treated with GH (1.4 U/kg/week) for 1 year and then studied for a 2nd year off GH. The treatment increased insulin-like growth factor 1 and insulin-like growth factor binding protein 3 plasma levels. All patients showed an increase in height velocity. Lean body mass increased by 12%. After the cessation of GH therapy, height velocity fell to pretreatment values, and weight and fat mass increased markedly. Bone formation and resorption markers significantly increased during treatment and returned to pretreatment values after discontinuation of GH treatment. These results suggest that GH may partially counteract the adverse effects of glucocorticoids on growth and metabolism in patients with chronic inflammatory disease.

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Basal and Stimulated Serum Growth Hormone Concentrations in Inflammatory Bowel Disease

Cited by 84 publications

References 11 publications

The Insulin-Like Growth Factor System and Markers of Inflammation in Adult Patients with Inflammatory Bowel Disease

The Insulin-Like Growth Factor System and Markers of Inflammation in Adult Patients with Inflammatory Bowel Disease

Effect of IL-6 on IGF Binding Protein-3: A Study in IL-6 Transgenic Mice and in Patients with Systemic Juvenile Idiopathic Arthritis

Treatment of Juvenile Rheumatoid Arthritis with Growth Hormone

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