Basal cell carcinoma in organ transplant recipients

Li, S.‐Y.; Qureshi, Abrar A.; Li, W.‐Q.

doi:10.1111/bjd.14260

Cited by 3 publications

(3 citation statements)

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“…[1][2][3] Some behavioral or environmental factors other than UV radiation, such as kidney transplant recipients, have been associated with a higher incidence of aggressive BCC subtypes. 4,5 Among these aggressive lesions, scleroderma-like basal cell carcinomas (SBCC) are the most common type.…”

Section: Discussionmentioning

confidence: 99%

Sclerodermiform basal cell carcinoma: rare form in a young patient

Assenhaji¹,

Bennani²,

Ziani³

et al. 2019

JCPCR

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Section: Discussionmentioning

confidence: 99%

Sclerodermiform basal cell carcinoma: rare form in a young patient

Assenhaji¹,

Bennani²,

Ziani³

et al. 2019

JCPCR

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“…Evidence shows that apart from immunosuppression, the personal and clinical factors associated with BCC in OTRs are similar to those in the general populations [4][5][6]. The mechanisms underlying their increased occurrence in OTRs are not well understood [7].…”

Section: Introductionmentioning

confidence: 99%

Basal cell carcinomas in organ transplant recipients versus the general population: clinicopathologic study

et al. 2022

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Organ transplant recipients (OTRs) are at greater risk of basal cell carcinomas (BCCs) than non-OTRs, but histopathologic differences between BCCs in OTRs and the general population are largely unknown. We compared clinicopathologic features of BCCs in OTRs vs the general population in Queensland, Australia. Details of BCC tumors (site, size, level of invasion, subtype, biopsy procedure) were collected from histopathology reports in two prospective skin cancer studies, one in OTRs and one general-population-based. We used log-binomial regression models to estimate age- and sex-adjusted prevalence ratios (PR) with 95% confidence intervals (CIs) for BCC features. Overall, there were 702 BCCs in 200 OTRs and 1725 BCCs in 804 population cases. Of these, 327 tumors in 128 OTRs were higher risk BCCs (any head and neck BCC; ≥ 2 cm on trunk/extremities), more per person than 703 higher risk BCCs in 457 cases in the general population (chi-square p = 0.008). Among head/neck BCCs, OTRs were more likely than general population cases to have BCCs on scalp/ear than on face/lip/neck (PR = 1.5, 95%CI 1.2–1.8). Although aggressive subtypes were less common among higher risk BCCs in OTRs, BCCs invading beyond the dermis were almost twice as prevalent in OTRs (PR = 1.8, 95% CI 1.3–2.6) than the general population.

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“…2 - 6 Certain behavioural and/or environmental factors, apart from UV radiation, such as kidney transplant recipients have been associated with a higher incidence of aggressive subtypes of BCC. 7 , 8 Among these aggressive lesions, sclerodermiform basal cell carcinomas (SBCC) are the most common type. This is a challenging-to-treat lesion due to its deep tissue invasion, rapid growth, risk of metastasis and overall poor prognosis if treatment is not initiated in early stages.…”

Section: Introductionmentioning

confidence: 99%

Sclerodermiform basal cell carcinoma: how much can we rely on dermatoscopy to differentiate from non-aggressive basal cell carcinomas? Analysis of 1256 cases

Husein‐ElAhmed¹

2018

An. Bras. Dermatol.

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BackgroundThe behaviour of each basal cell carcinoma is known to be different according to the histological growth pattern. Among these aggressive lesions, sclerodermiform basal cell carcinomas are the most common type. This is a challenging-to-treat lesion due to its deep tissue invasion, rapid growth, risk of metastasis and overall poor prognosis if not diagnosed in early stages.ObjectiveTo investigate if sclerodermiform basal cell carcinomas are diagnosed later compared to non-sclerodermiform basal cell carcinoma Method: All lesions excised from 2000 to 2010 were included. A pathologist classified the lesions in two cohorts: one with specimens of non-aggressive basal cell carcinoma (superficial, nodular and pigmented), and other with sclerodermiform basal cell carcinoma. For each lesion, we collected patient's information from digital medical records regarding: gender, age when first attending the clinic and the tumor location.Results1256 lesions were included, out of which 296 (23.6%) corresponded to sclerodermiform basal cell carcinoma, whereas 960 (76.4%) were non-aggressive subtypes of basal cell carcinoma. The age of diagnosis was: 72.78±12.31 years for sclerodermiform basal cell and 69.26±13.87 years for non-aggressive basal cell carcinoma (P<.0001). Sclerodermiform basal cell carcinomas are diagnosed on average 3.52 years later than non-aggressive basal cell carcinomas. Sclerodermiform basal cell carcinomas were diagnosed 3.40 years and 2.34 years later than non-aggressive basal cell carcinomas in younger and older patients respectively (P=.002 and P=.03, respectively).Study limitationsretrospective design.ConclusionThe diagnostic accuracy and primary clinic conjecture of sclerodermiform basal cell carcinomas is quite low compared to other forms of basal cell carcinoma such as nodular, superficial and pigmented. The dermoscopic vascular patterns, which is the basis for the diagnosis of non-melanocytic nonpigmented skin tumors, may not be particularly useful in identifying sclerodermiform basal cell carcinomas in early stages. As a distinct entity, sclerodermiform basal cell carcinomas show a lack of early diagnosis compared to less-aggressive subtypes of BCC, and thus, more accurate diagnostic tools apart from dermatoscopy are required to reach the goal of early-stage diagnosis of sclerodermiform basal cell carcinomas.

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Basal cell carcinoma in organ transplant recipients

Abstract: Linked Article: Krynitz, et al. Br J Dermatol 2016; 174: 95–103.

Cited by 3 publications

References 10 publications

Sclerodermiform basal cell carcinoma: rare form in a young patient

Sclerodermiform basal cell carcinoma: rare form in a young patient

Basal cell carcinomas in organ transplant recipients versus the general population: clinicopathologic study

Sclerodermiform basal cell carcinoma: how much can we rely on dermatoscopy to differentiate from non-aggressive basal cell carcinomas? Analysis of 1256 cases

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