Basal cell carcinoma of the lower extremities

Pearson, Greg; King, Lloyd E.; Boyd, Alan S.

doi:10.1046/j.1365-4362.1999.00787.x

Cited by 17 publications

(14 citation statements)

References 9 publications

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“…Contrasting data are reported according to the distribution by sex of patients with BCCs on lower limbs. In our study, the vast majority of patients enrolled were males (51/81 cases), which is in contrast with a previous report of 150 cases, in which females were predominant [15], but in agreement with further studies [10,11]. Our results also showed that the vast majority of BCCs of the lower extremities were superficial in histologic subtype, according to previous studies [10,16].…”

Section: Discussionsupporting

confidence: 91%

Dermoscopic Features of Basal Cell Carcinoma on the Lower Limbs: A Chameleon!

et al. 2017

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Background:Lower limbs represent an uncommon location for basal cell carcinoma (BCC) and only few reports have described dermoscopic features of BCC in this body site. Since BCCs of the lower limbs frequently display nonclassic BCC dermoscopic criteria, they can simulate other benign or malignant lesions. Objective: Our aim was to describe the dermoscopic features of BCC located on lower limbs and to define which criteria were more associated with their benignor malignant-looking appearance. Methods: We conducted a retrospective study enrolling consecutive patients with histologically confirmed BCCs of the lower limbs. Lesions were classified in 7 categories according to the clinical and dermoscopic global appearance. Clear BCC, squamous cell carcinoma (SCC) or Bowen disease-like, Kaposi disease-like, melanoma-like, and aspecific pattern were considered malignant-looking lesions; however, seborrheic keratosis-like and dermatofibroma-like were considered benign-looking. To define which dermoscopic criteria were independently associated with benign-or malignant-looking appearance, we conducted a multivariate logistic regression analysis. Results:A total of 81 BCCs were enrolled: 18 (22%) were benign-looking lesions (of which 11 were seborrheic keratosis-like and 7 dermatofibroma-like) and 63 (78%) were malignant-looking BCCs (of which 24 were clear-cut BCCs, 23 SCC-like, 2 Kaposi disease-like, 9 melanoma-like, and 5 had aspecific pattern). Multivariate regression analysis showed that erosions/ulceration and vessels were independently associated with malignant-looking appearance. The most represented vessels were glomerular and polymorphic, which are more frequently encountered in SCC, together with ulceration. Conclusion: BCC of the lower legs frequently simulates other benign or malignant lesions, with SCC being the main differential diagnosis.

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Section: Discussionsupporting

confidence: 91%

Dermoscopic Features of Basal Cell Carcinoma on the Lower Limbs: A Chameleon!

et al. 2017

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“…26 Likewise, the findings of the present study confirm the male propensity for lesions on the trunk, although the strength of this association was not as great as that of the lower limbs for women.…”

Section: Discussionsupporting

confidence: 49%

“…Many of the findings corroborate previous international studies that had already reported a predilection of BCC for the trunk in men and for the lower limbs in women (Graph 2). 18,[26][27][28] No other statistically significant trends were found with respect to any of the other body sites in either males or females. Regarding the face, there was an evident propensity for women to develop lesions on the nose and upper lip and for men to develop lesions on the sides of the face, ears and scalp (Graph 3).…”

Section: Discussionmentioning

confidence: 81%

Topografia do carcinoma basocelular e suas correlações com o gênero, a idade e o padrão histológico: um estudo retrospectivo de 1.042 lesões

Souza

Thomé

Menegotto

et al. 2011

An. Bras. Dermatol.

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BACKGROUND: Basal cell carcinoma accounts for 75% of skin cancer. Sun exposure and genetics are related to its etiology. It's expected that biological and behavioral differences provide different patterns of involvement between sexes. OBJECTIVES: To evaluate the topography of lesions and their correlations with gender, age and histological type. METHODS: Retrospective study of basal cell carcinoma patients treated between 1999 and 2008 in the Skin Cancer Clinic of Santa Casa de Misericordia of Curitiba. We evaluated sex, age, location, histological type, margins commitment, sun exposure and family skin cancer history. RESULTS: We found 1042 lesions in 545 patients (61% women), being more numerous in men (p<0.01). Their ages ranged between 27 and 95 years (median=65). Men had more sun exposure (p<0.01). The lesions were more frequent extra-cephalic recently (p<0.01). The margin involvement was higher in the head (p<0.01). The superficial type was less frequent on the head (p<0.01) and was associated with younger ages in women (p<0.01). The head housed 74% of lesions and the legs 2%. Women had a predilection for the legs, nose and upper lip and men to trunk, ears and scalp (p <0.05). The surgeries in the medial epicanthus and scalp occurred at younger ages (p=0.01). CONCLUSIONS: We identified significant associations between the topography of lesions, gender, age and histological type, demonstrating the possible pathophysiological diversity and differential risk factors operation. In the period studied we found no trend of increase in the proportion of young or women among patients. Keywords: Age distribution; Carcinoma, basal cell; Pathology; Sex distribution; Topography Resumo: FUNDAMENTOS: O carcinoma basocelular corresponde a 75% dos tumores cutâneos. A exposição solar e a genética estão relacionadas à sua etiologia. Espera-se que diferenças comportamentais e biológicas proporcionem padrões diferenciados de acometimento entre os sexos. OBJETIVOS: Avaliar a topografia das lesões e suas correlações com gênero, idade e tipo histológico. MÉTODOS: Estudo retrospectivo de pacientes tratados por carcinoma basocelular entre 1999 e 2008 no ambulatório de câncer da pele da Santa Casa de Misericórdia de Curitiba. Avaliamos sexo, idade, localização, tipo histológico, situação das margens, histórico de fotoexposição e antecedentes familiares de câncer cutâneo. RESULTADOS: Contabilizamos 1.042 lesões em 545 pacientes (61% mulheres), sendo mais numerosas nos homens (p < 0,01). As idades variaram entre 27 e 95 anos (mediana = 65). Os homens apresentavam mais fotoexposição (p < 0,01). As lesões extracefálicas foram mais frequentes recentemente (p < 0,01). O comprometimento de margens foi maior na cabeça (p < 0,01). O tipo superficial foi menos frequente na cabeça (p < 0,01) e se associou a idades menores nas mulheres (p < 0,01). A cabeça abrigou 74% das lesões, e as pernas, 2%. As mulheres apresentaram predileção para pernas, nariz e lábio superior e os homens para tronco, orelhas e couro cabeludo (p < 0,05). As ciru...

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“…BCC is a nonmelanocytic skin malignancy arising from basal cells of the epidermis or follicular structures and is seen mostly on sun exposed areas, especially head and neck, occasionally over the trunk and limbs, and rarely on the palms, soles, mucous membranes, and genitals [4,5].…”

Section: Introductionmentioning

confidence: 99%

A study of basal cell carcinoma in South Asians for risk factor and clinicopathological characterization: A hospital based study

2015

Journal of the American Academy of Dermatology

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Objectives. Although the incidence of skin cancers in India (part of South Asia) is low, the absolute number of cases may be significant due to large population. The existing literature on BCC in India is scant. So, this study was done focusing on its epidemiology, risk factors, and clinicopathological aspects. Methods. A hospital based cross-sectional study was conducted in Punjab, North India, from 2011 to 2013. History, examination and histopathological confirmation were done in all the patients visiting skin department with suspected lesions. Results. Out of 36 confirmed cases, 63.9% were females with mean ± SD age being 60.9 ± 14.2 years. Mean duration of disease was 4.7 years. Though there was statistically significant higher sun exposure in males compared to females ( value being 0.000), BCC was commoner in females, explainable by intermittent sun exposure (during household work in the open kitchens) in women. Majority of patients (88.9%) had a single lesion. Head and neck region was involved in 97.2% of cases, with nose being the commonest site (50%) with nodular/noduloulcerative morphology in 77.8% of cases. Pigmentation was evident in 22.2% of cases clinically. Nodular variety was the commonest histopathological variant (77.8%).Conclusions. This study highlights a paradoxically increasing trend of BCC with female preponderance, preferential involvement of nose, and higher percentage of pigmentation in Indians.

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Basal cell carcinoma of the lower extremities

Abstract: Basal cell carcinomas of the lower extremities occur more often in women in the USA and are of the superficial subtype. This may be due to differing patterns of dress and exposure to the sun.

Cited by 17 publications

References 9 publications

Dermoscopic Features of Basal Cell Carcinoma on the Lower Limbs: A Chameleon!

Dermoscopic Features of Basal Cell Carcinoma on the Lower Limbs: A Chameleon!

Topografia do carcinoma basocelular e suas correlações com o gênero, a idade e o padrão histológico: um estudo retrospectivo de 1.042 lesões

A study of basal cell carcinoma in South Asians for risk factor and clinicopathological characterization: A hospital based study

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