Basal Cell Carcinoma of the Head and Neck Region: An Analysis of 171 Cases

Abstract

Objective. To analyze the pattern of presentation of basal cell carcinoma (BCC) and margin status for excised specimens in the head and neck region. Study Design. Retrospective cross-sectional. Duration of Study. January 2009 to December 2011. Methodology. The database of the pathology department was searched to identify records of all malignant skin tumors that underwent standard excision with margins. Out of these records, tumors with a diagnosis of BCC in the head and neck region were retrieved and separated. Age, gender, anatomic location, pattern of tumor, and margin status were noted. Results. A total of 171 cases of BCC from various sites of head and neck were retrieved. Male to female ratio was 1.4 : 1. The age ranged from 22 to 90 years. Seventy-six cases presented on right side, 79 on left, and 16 were in the midline. Most common anatomical site was the nose followed by the cheek. Nodular lesions were the most common (46.2%) followed by pigmented variety (18.7%). Margins were clear in 77 (45.1%) cases, involved in 86 (50.2%) cases, and close in 8 (4.7%) cases. Conclusion. Nose was the most common site followed by the cheek. Nodular and pigmented varieties were the most frequent and margins were involved in more than fifty percent of the cases.

Rare Case Report of Bilateral Pigmented Lesion on Alae of Nose

“…Jacob Arthur in Dublin in 1827 first coined the term "rodent ulcer"to describe basal cell carcinoma.BCC comprises 65% of all malignant skin tumor and 80% of non-melanoma cancer 4 .It occurs mostly in fourth decade of life or later but also reported in younger patients with male:female ratio 3:2.Combination of environmentl factors,phenotype and genetic predisposition are the main aetiological factors 5 .Among environmental factors,intermittent U.V radiation exposure is most important risk factor and other less important are exposure to ionising radiation,arsenic and coal tar 6 .Bart RS et al also noted that pigmented BCC is more common in dark eyed people and very rare in blue eyed people.There are many subtypes of BCC like nodular,superficial,spreading,pigmented,cystic,micronodular,morphea form and infiltrating,of which nodular form is most common 7 .According to study done by RoKW et al,pigmented BCC shows lesser subclinical infiltration than nonpigmented BCC.Pigmentation can be found indifferent clinical variant of BCC but vary in colour depending on no. of melanocytes and amount of melanin present within tumor.HMB45 and S100 currently two most useful immunomarker to identify melanocytes and melanoma.Differential diagnosis for pigmented BCC include pigmented naevus,melamoma,pigmented seborrheic keratosis and pigmented Bowens disease 8 .…”

Pigmented Basal Cell Carcinoma: An Unusual Case Report

“…In our case the patient was a farmer and used to spend most of his time in the open field. BCC is believed by many to arise from pluripotential cells within the basal layer of the epidermis of follicular structures [1,4]. BCC occurs most frequently in the fourth decade of life or later but it has also been reported as occurring in younger persons.…”

“…Jacob Arthur in Dublin in 1827 first coined the term "rodent ulcer" to describe what we now know as basal cell carcinoma [1]. It is the most common carcinoma of the skin [2,3].…”

Pigmented Basal Cell Carcinoma of the External Auditory Canal: A Case Report

“…Lokalizasyon olarak en sık baş-boyun bölgesinde bulunmakla birlikte, temporal bölgede ender görülmektedir. Özellikle pigmente BCC dış kulak yolunda çok daha ender görül-mektedir (1,2) . Biz de bu makalemizde dış kulak yolu pigmente bazal hücreli karsinom tanısı koyup tedavi ettiğimiz olguyu sunduk.…”

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ÖZ

Bazal hücreli karsinom (BCC), bazal hücrelerin proliferas-

GİrİşBazal hücreli karsinom (BCC) ilk kez 1827 yılında Jacob Arthur tarafından kemirici ülser (rodent ulcer) kavramıyla ortaya atılmıştır (1) . BCC, bazal hücrelerin proliferasyonuyla karakterize yüzeyel yayılan genellikle lokal agresif çok ender olarak metastaz yapan bir tümördür.

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