Basal cell carcinoma with a sarcomatous component (carcinosarcoma): A series of 5 cases and a review of the literature

Rose, R. F.; Merchant, W.; Stables, G.I.; Lyon, Calum C.; Platt, Alastair J.

doi:10.1016/j.jaad.2008.05.035

Cited by 36 publications

(46 citation statements)

References 21 publications

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“…The first, known as the collision theory, proposes that two individual stem cells may simultaneously and independently undergo malignant transformation and are actually separate tumours that have collided 7 . The second, composition theory is that the spindle cell component is a reaction to the carcinoma 7 . The third, divergence theory is that individual elements are derived from a single common precursor cell 7 .…”

Section: Discussionmentioning

confidence: 99%

“…The second, composition theory is that the spindle cell component is a reaction to the carcinoma 7 . The third, divergence theory is that individual elements are derived from a single common precursor cell 7 . In most cases of oesophageal carcinosarcoma, it has been suggested that the sarcomatous component generally results from differentiation of squamous cell carcinoma cells into mesenchymal tumour cells.…”

Section: Discussionmentioning

confidence: 99%

“…The tongue is the second most frequent site of metastasis in the oral mucosa and represents approximately 28% of all malignant metastatic tumours of the oral mucosa 3 . Carcinosarcoma is a rare malignant tumour composed of both carcinomatous and sarcomatous elements, which has been described in the breast, colon, lung and urogenital tract 7 . Primary cutaneous carcinosarcomas are rare, and approximately 50 cases have been reported in the English literature 7 .…”

mentioning

confidence: 99%

“…Carcinosarcoma is a rare malignant tumour composed of both carcinomatous and sarcomatous elements, which has been described in the breast, colon, lung and urogenital tract 7 . Primary cutaneous carcinosarcomas are rare, and approximately 50 cases have been reported in the English literature 7 . In cutaneous carcinosarcoma, metastasis has occurred in 7-29% of all patients 6,7,9 .…”

mentioning

confidence: 99%

“…Primary cutaneous carcinosarcomas are rare, and approximately 50 cases have been reported in the English literature 7 . In cutaneous carcinosarcoma, metastasis has occurred in 7-29% of all patients 6,7,9 . A search revealed no case of carcinosarcoma metastatic to the oral mucosa.…”

mentioning

confidence: 99%

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Metastatic cutaneous carcinosarcoma to the tongue

Tanaka¹,

Hidaka²,

Yamamura³

et al. 2010

International Journal of Oral and Maxillofacial Surgery

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Metastatic cutaneous carcinosarcoma to the tongue

Tanaka¹,

Hidaka²,

Yamamura³

et al. 2010

International Journal of Oral and Maxillofacial Surgery

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Cutaneous carcinosarcoma: further insights into its mutational landscape through massive parallel genome sequencing

et al. 2014

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Cutaneous carcinosarcoma (CCS) is an extraordinarily rare neoplasm with a biphasic morphological pattern exhibiting both epithelial and sarcomatoid components. Although its histogenesis and biological aspects remain poorly understood, previous studies have postulated that this tumor may arise from single cancer stem cells which subsequently differentiate into distinct tumor lineages. In this study, we explored a wide array of mutational hot spot regions, through high-depth next-generation sequencing of 47 cancer-associated genes in order to assess the mutational landscape of these tumors and investigate whether the epithelial and mesenchymal components shared the same genetic signatures. Results from this study confirm that despite their striking phenotypic differences, both elements of this infrequent tumor indeed share a common clonal origin. Additionally, CCS appears to embrace a heterogeneous spectrum with specific underlying molecular signatures correlating with the defining epithelial morphotype, with those carcinosarcomas exhibiting a squamous cell carcinoma epithelial component exhibiting diverse point mutations and deletions in the TP53 gene, and those with a basal cell carcinoma morphotype revealing a more complex mutational landscape involving several genes. Also, the fact that our findings involve several targetable gene pathways suggests that the underlying molecular events driving the pathogenesis of CCS may represent future potential targets for personalized therapies.

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