Basal dendritic length is reduced in the rat hippocampus following bilateral vestibular deafferentation

Balabhadrapatruni, Sangeeta; Zheng, Yiwen; Napper, Ruth M. A.; Smith, Paul F.

doi:10.1016/j.nlm.2016.03.009

Cited by 16 publications

(9 citation statements)

References 36 publications

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“…In theory, the elevation in cortisol could be attributed to both the stress of disturbed sleep patterns and to vestibular dysfunction, and it has been shown that chronically elevated levels of cortisol may contribute to hippocampal atrophy. This last point was elaborated further in other studies that found correlations between hippocampal atrophy and bilateral vestibular loss (Van Cruijsen, Hiemstra et al 2007, Aitken, Benoit et al 2016, Balabhadrapatruni, Zheng et al 2016, Seo, Kim et al 2016.…”

Section: Discussionmentioning

confidence: 53%

Vestibular vertigo is associated with abnormal sleep duration

Albathi

Agrawal

2017

VES

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Section: Discussionmentioning

confidence: 53%

Vestibular vertigo is associated with abnormal sleep duration

Albathi

Agrawal

2017

VES

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“…Electricophysiology studies showed that bilateral lesions of the peripheral vestibular system completely abolished location-related firing and theta rhythm generation in CA1 neurons 53 54 . Bilateral vestibular deafferentation significantly decreased basal dendritic length in the rat hippocampal CA1 region 55 . Damage to the peripheral vestibular system also induced changes in expression of hippocampal NMDA receptor subunits, and reduced spatial training-associated increases in glutamate receptor and αCaMKII expression in rats 56 57 58 .…”

Section: Discussionmentioning

confidence: 87%

Storage of passive motion pattern in hippocampal CA1 region depends on CaMKII/CREB signaling pathway in a motion sickness rodent model

Wang¹,

Liu²,

Pan³

et al. 2017

Sci Rep

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Sensory mismatch between actual motion information and anticipated sensory patterns (internal model) is the etiology of motion sickness (MS). Some evidence supports that hippocampus might involve the neural storage of the “internal model”. This study established an “internal model” acquisition-retention behavioral model using a repeated habituation rotation training protocol. We tried to identify the hippocampal subregion involved in “internal model” retention using chemical lesion methods. Hippocampal kinases (CaMK, CaMKIV, CREB and ERK1/2) phosphorylation in the target subregion was assayed and the effects of kinase inhibitors (KN93 or U0126) on “internal model” retention were investigated. The activities of potential kinases (CaMKII and CREB) were also examined in otoliths deficit het/het mice. In habituated rats, CA1 lesion reproduced MS-related behavioral responses on “internal model” retention day. Habituation training increased CaMKII and CREB activity but had no effect on CaMKIV and ERK1/2 activity in the CA1, while inhibition of CaMKII but not ERK1/2 impaired “internal model” retention. In het/het mice, CaMKII and CREB were not activated in the CA1 on the retention day. These results suggested that CaMKII/CREB pathway might potentially contribute to the storage of the “internal model” in the hippocampal CA1 after motion sickness induced by vestibular stimulation.

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“…Inactivation of the vestibular system has also recently been reported to abolish theta activity in the entorhinal cortex (Jacob et al, ). Furthermore, a loss of dorsal hippocampal volume has been found in humans following bilateral vestibular lesions (BVL) (Brandt et al, ; Gottlich et al, ; Seo et al, 2016) and in rodents a decrease in the length of basal dendrites in CA1 has been reported (Balabhadrapatruni et al, ). However, such anatomical hippocampal changes remain controversial due to conflicting results obtained in human (Van Cruijsen et al, ; Cutfield et al, ) and no change in hippocampal volume has been observed in rats following either chemical or surgical BVL (Besnard et al, ; Zheng et al, ).…”

Section: Introductionmentioning

confidence: 99%

Hippocampal and striatal M₁‐muscarinic acetylcholine receptors are down‐regulated following bilateral vestibular loss in rats

et al. 2016

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Permanent vestibular loss has detrimental effects on the hippocampus, resulting in a disruption to spatial learning and memory, hippocampal theta rhythm and place cell field spatial coherence. Little is known about the vestibular system-related hippocampal cholinergic transmission. Since the pharmacological blockade of muscarinic acetylcholine (ACh) receptors within the hippocampus produces deficits in learning and memory, we hypothesized that ACh receptors may at least partly support the integration of vestibular input. Consequently, we examined the expression of M muscarinic ACh receptors in the hippocampus at 7 and 30 days following bilateral vestibular lesions (BVL) in rats using autoradiography. Animals were divided into sham (n = 12) and BVL (n = 11) groups. BVL animals received intratympanic injections of sodium arsanilate (30 mg/0.1 ml) under isoflurane anesthesia and sham animals received the same volume of saline. Analysis of the brain tissue revealed a significant reduction in the number of M receptors throughout the hippocampus and striatum at 30 days (P ≤ 0.0001), but not at 7 days following BVL. This suggests that the changes in learning and memory seen following vestibular damage may be in part due to the loss of M muscarinic receptors in the hippocampus and striatum. © 2016 Wiley Periodicals, Inc.

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Basal dendritic length is reduced in the rat hippocampus following bilateral vestibular deafferentation

Cited by 16 publications

References 36 publications

Vestibular vertigo is associated with abnormal sleep duration

Vestibular vertigo is associated with abnormal sleep duration

Storage of passive motion pattern in hippocampal CA1 region depends on CaMKII/CREB signaling pathway in a motion sickness rodent model

Hippocampal and striatal M₁‐muscarinic acetylcholine receptors are down‐regulated following bilateral vestibular loss in rats

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Basal dendritic length is reduced in the rat hippocampus following bilateral vestibular deafferentation

Cited by 16 publications

References 36 publications

Vestibular vertigo is associated with abnormal sleep duration

Vestibular vertigo is associated with abnormal sleep duration

Storage of passive motion pattern in hippocampal CA1 region depends on CaMKII/CREB signaling pathway in a motion sickness rodent model

Hippocampal and striatal M1‐muscarinic acetylcholine receptors are down‐regulated following bilateral vestibular loss in rats

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Hippocampal and striatal M₁‐muscarinic acetylcholine receptors are down‐regulated following bilateral vestibular loss in rats