Basal forebrain cholinergic lesions disrupt increments but not decrements in conditioned stimulus processing

Chiba, Andrea A.; Bucci, David J.; Holland, Peter C.; Gallagher, Michela

doi:10.1523/jneurosci.15-11-07315.1995

Cited by 243 publications

(225 citation statements)

References 38 publications

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“…Likewise, whereas in intact rats the surprising omission of anticipated events increases attention to stimuli that accompany that surprise, enhancing subsequent learning about those stimuli, rats with CeA lesions fail to show such enhancement (Holland and Gallagher, 1993). Other studies from our laboratory show that these surprise-induced enhancements of attention are mediated by circuitry that includes the CeA, cholinergic neurons in the basal forebrain nucleus basalis/substantia innominata, and the posterior parietal cortex (Chiba et al, 1995;Bucci et al, 1998;Han et al, 1999). Thus, it appears that the CeA can regulate various aspects of attentional information processing through its influence on different brain circuitry.…”

Section: Discussionmentioning

confidence: 72%

Role of Amygdalo-Nigral Circuitry in Conditioning of a Visual Stimulus Paired with Food

et al. 2005

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The amygdala central nucleus (CeA) plays an important part in associative learning. Although most research has focused on functions of its descending projections to brainstem areas involved in autonomic and somatomotor responses, the ascending projections of CeA also play critical roles in learning. For example, a CeA-nigrostriatal pathway is important for acquiring orienting responses (ORs) to conditioned stimuli (CSs) that signal food delivery. In this study, the function of this CeA-nigrostriatal pathway in appetitive conditioning of rats was considered in more detail.In experiment 1, we combined anatomical tracing and methods for detecting neuronal activation to examine whether CeA neurons that project to the substantia nigra pars compacta (

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Section: Discussionmentioning

confidence: 72%

Role of Amygdalo-Nigral Circuitry in Conditioning of a Visual Stimulus Paired with Food

et al. 2005

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“…Other research with these same tasks has indicated that another system, which includes the central nucleus of the amygdala (CN) and its projections to the nucleus basalis magnocellularis /substantia innominata (nBM /SI), controls incremental processing independent of decremental processing: lesions of CN or of cholinergic neurons in the nBM /SI spare decremental processing (e.g., latent inhibition) but eliminate incremental processing (like that produced by the shift in the serial conditioning procedure; Holland and Gallagher, 1993;Chiba et al, 1995). Within this system cholinergic projections from the nBM /SI to neocortex are hypothesized to modulate information processing in the cortex (Holland and Gallagher, 1993;Gallagher and Holland, 1994;Chiba et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

“…Within this system cholinergic projections from the nBM /SI to neocortex are hypothesized to modulate information processing in the cortex (Holland and Gallagher, 1993;Gallagher and Holland, 1994;Chiba et al, 1995). By analogy, the role of the hippocampus in decremental processing may be like that of CN in incremental processing; that is, it may regulate processing in cortical targets of the MS/ VDB (e.g., cingulate cortex) (Amaral and Kurz, 1985;Gaykema et al, 1990) via its efferent projections to the septum (Swanson, 1977;Swanson and Cowan, 1977;Gaykema et al, 1991).…”

Section: Discussionmentioning

confidence: 99%

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Disruption of Decrements in Conditioned Stimulus Processing by Selective Removal of Hippocampal Cholinergic Input

1997

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The attention directed to environmental stimuli can be modified by experience. For example, preexposure of a conditioned stimulus (CS) in the absence of reinforcement can retard subsequent conditioning of that stimulus when it is paired directly with an unconditioned stimulus, a phenomenon referred to as latent inhibition. Similarly, consistent pairings of a CS with another event can slow the acquisition of new information about that CS. Such phenomena suggest that reductions in the processing of CSs occur when they are made behaviorally irrelevant or consistent predictors of other events. On the basis of the observation that hippocampal lesions prevented such reductions in CS processing, we hypothesized that damage to basal forebrain cholinergic neurons that project to the hippocampus, using microinjections of the selective immunotoxin 192 IgG-saporin into the medial septum/vertical limb of the diagonal band (MS/VDB), also would disrupt normal reductions in CS processing. Lesions of hippocampal cholinergic input disrupted decreases in CS processing, manifested in both an absence of latent inhibition and a lack of reduced processing of a CS that had been a consistent predictor of another CS. These results indicate that cholinergic neurons in the MS/VDB play a role in the regulation of CS processing. Furthermore, these findings (in conjunction with previous findings) implicate both rostral (hippocampal-projecting) and caudal (corticalprojecting) regions of the basal forebrain cholinergic system in the modulation of attention.

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“…The nature of the mnemonic effects produced by certain cholinergic manipulations suggests a role in enhancing cortical information processing to facilitate acquisition of new material (Chiba et al, 1995;Bucci et al, 1998;Furey et al, 2000;McGaughy et al, 2005), a function for cortical ACh that would be consistent with its broader role in attention (Sarter et al, 2003). Conversely, results from studies with postacquisition manipulations have suggested that ACh may be directly involved in memory consolidation.…”

Section: Introductionmentioning

confidence: 99%

Paradoxical Facilitation of Object Recognition Memory after Infusion of Scopolamine into Perirhinal Cortex: Implications for Cholinergic System Function

Winters¹,

Saksida²,

Bussey³

2006

J. Neurosci.

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The cholinergic system has long been implicated in learning and memory, yet its specific function remains unclear. In the present study, we investigated the role of cortical acetylcholine in a rodent model of declarative memory by infusing the cholinergic muscarinic receptor antagonist scopolamine into the rat perirhinal cortex during different stages (encoding, storage/consolidation, and retrieval) of the spontaneous object recognition task. Presample infusions of scopolamine significantly impaired object recognition compared with performance of the same group of rats on saline trials; this result is consistent with previous reports supporting a role for perirhinal acetylcholine in object information acquisition. Scopolamine infusions directly before the retrieval stage had no discernible effect on object recognition. However, postsample infusions of scopolamine with sample-to-infusion delays of up to 20 h significantly facilitated performance relative to postsample saline infusion trials. Additional analysis suggested that the infusion episode could cause retroactive or proactive interference with the sample object trace and that scopolamine blocked the acquisition of this interfering information, thereby facilitating recognition memory. This is, to our knowledge, the first example of improved recognition memory after administration of scopolamine. The overall pattern of results is inconsistent with a direct role for cortical acetylcholine in declarative memory consolidation or retrieval. Rather, the cholinergic input to the perirhinal cortex may facilitate acquisition by enhancing the cortical processing of incoming stimulus information.

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Basal forebrain cholinergic lesions disrupt increments but not decrements in conditioned stimulus processing

Cited by 243 publications

References 38 publications

Role of Amygdalo-Nigral Circuitry in Conditioning of a Visual Stimulus Paired with Food

Role of Amygdalo-Nigral Circuitry in Conditioning of a Visual Stimulus Paired with Food

Disruption of Decrements in Conditioned Stimulus Processing by Selective Removal of Hippocampal Cholinergic Input

Paradoxical Facilitation of Object Recognition Memory after Infusion of Scopolamine into Perirhinal Cortex: Implications for Cholinergic System Function

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