Basal metabolic rate and thyroid hormones of late-middle-aged and older human subjects: the ZENITH study

Meunier, N; Beattie, John; Ciarapica, Donatella; O’Connor, Jacqueline M.; Andriollo-Sanchez, M; Taras, Andrea; Coudray, Charles; Polito, Angela

doi:10.1038/sj.ejcn.1602299

Cited by 22 publications

(11 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The factors associated with BEE have mainly been investigated in non‐diabetic humans. Age, fat mass, fat‐free mass/muscle mass, sympathetic nerve activity and thyroid hormone are all associated with BEE. However, these relationships remain unclear in humans with diabetes, who are associated with an increased risk of sarcopenia.…”

Section: Discussionmentioning

confidence: 99%

Fat‐free mass and calf circumference as body composition indices to determine non‐exercise activity thermogenesis in patients with diabetes

Isobe

Sakurai

Kita

et al. 2015

J of Diabetes Invest

View full text Add to dashboard Cite

Aims/IntroductionTo investigate the clinical and anthropometrical parameters that are associated with non‐exercise activity thermogenesis that is composed of basal energy expenditure (BEE) and diet‐induced thermogenesis (DIT) in patients with diabetes.Materials and MethodsBody composition was assessed using bioelectrical impedance, and BEE and DIT were measured using indirect calorimetry in 40 Japanese patients with diabetes.Results BEE correlated positively with bodyweight, body mass index, fat mass, and fat‐free mass, and correlated negatively with age in both men and women. In multivariate logistic regression analysis, BEE correlated positively with both fat mass and fat‐free mass independently of sex and age. In addition, DIT correlated positively with bodyweight, body mass index, fat mass and fat‐free mass, and correlated negatively with age in women, but not men. Fat‐free mass contributed to DIT at least partly, and an aging‐related decrease in DIT was observed. The best anthropometric parameter that reflected fat mass and fat‐free mass was hip circumference (HC) and calf circumference (CC), respectively, in both men and women. Indeed, both HC (men β = 0.600, P < 0.001; women β = 0.752, P < 0.001) and CC (men β = 0.810, P = 0.012; women β = 0.821, P = 0.002) were correlated with BEE independently of age and sex. In addition, CC (β = 0.653, P = 0.009), but not HC was correlated with DIT significantly only in females, independently of age.Conclusions HC reflects fat mass and was positively associated with BEE, but not with DIT. In contrast, CC reflects fat‐free mass, and was positively associated with BEE in both men and women, and with DIT in women.

show abstract

Section: Discussionmentioning

confidence: 99%

Fat‐free mass and calf circumference as body composition indices to determine non‐exercise activity thermogenesis in patients with diabetes

Isobe

Sakurai

Kita

et al. 2015

J of Diabetes Invest

View full text Add to dashboard Cite

show abstract

“…Such an increase was not observed by Wada and King [22] . More recently, Meunier et al [33] reported a moderate negative correlation between total T 4 and red blood cell zinc (r = -0.12, p ! 0.02) in middleaged to older adults; however, they did not supplement their subjects with zinc.…”

Section: Thyroid Hormone Concentrationsmentioning

confidence: 99%

Effect of Zinc Supplementation on Thyroid Hormone Function

Maxwell

Volpe

2007

Ann Nutr Metab

View full text Add to dashboard Cite

Background/Aims: Zinc is crucial for proper thyroid hormone metabolism; zinc deficiency may result in decreased thyroid hormone levels and resting metabolic rate (RMR). The purpose of this investigation was to assess the effects of zinc supplementation on plasma zinc, serum ferritin, plasma total triiodothyronine (T₃) and thyroxine (T₄), serum free T₃ and T₄, and thyroid-stimulating hormone concentrations, and RMR in zinc-deficient, physically active women. Methods: Two zinc-deficient female college students (ZD1 and ZD2) were supplemented with 26.4 mg/day of zinc (as zinc gluconate), and the above parameters were analyzed at 0, 2 and 4 months. Results: Zinc deficiency was clinically corrected in both subjects, while serum ferritin concentration declined to classify both subjects as borderline iron deficient (ZD1 = 15.3 and ZD2 = 15.3 ng/ml at 4 months). At 4 months, total T₃ concentrations increased in ZD1, while all thyroid hormone concentrations increased in ZD2. RMR increased in both subjects by 4 months. Conclusion: Zinc supplementation appeared to be directly responsible for the increase in plasma zinc and decline in serum ferritin concentrations in both subjects. Zinc supplementation appeared to have a favorable effect on thyroid hormone levels, particularly total T₃, and RMR.

show abstract

“…Although endocrine effects have to be separated from alterations of body composition and PA behavior with aging, RMR is lower in older individuals, potentially even after adjusting for differences in body composition [ 43 ]. The age-related decline of RMR, however, cannot fully be ascribed to alterations of body composition or differences in thyroid hormone status [ 55 ].…”

Section: Physiological Changes In Older Athletesmentioning

confidence: 99%

Nutrition for Older Athletes: Focus on Sex-Differences

et al. 2021

View full text Add to dashboard Cite

Regular physical exercise and a healthy diet are major determinants of a healthy lifespan. Although aging is associated with declining endurance performance and muscle function, these components can favorably be modified by regular physical activity and especially by exercise training at all ages in both sexes. In addition, age-related changes in body composition and metabolism, which affect even highly trained masters athletes, can in part be compensated for by higher exercise metabolic efficiency in active individuals. Accordingly, masters athletes are often considered as a role model for healthy aging and their physical capacities are an impressive example of what is possible in aging individuals. In the present review, we first discuss physiological changes, performance and trainability of older athletes with a focus on sex differences. Second, we describe the most important hormonal alterations occurring during aging pertaining regulation of appetite, glucose homeostasis and energy expenditure and the modulatory role of exercise training. The third part highlights nutritional aspects that may support health and physical performance for older athletes. Key nutrition-related concerns include the need for adequate energy and protein intake for preventing low bone and muscle mass and a higher demand for specific nutrients (e.g., vitamin D and probiotics) that may reduce the infection burden in masters athletes. Fourth, we present important research findings on the association between exercise, nutrition and the microbiota, which represents a rapidly developing field in sports nutrition.

show abstract

Basal metabolic rate and thyroid hormones of late-middle-aged and older human subjects: the ZENITH study

Cited by 22 publications

References 31 publications

Fat‐free mass and calf circumference as body composition indices to determine non‐exercise activity thermogenesis in patients with diabetes

Fat‐free mass and calf circumference as body composition indices to determine non‐exercise activity thermogenesis in patients with diabetes

Effect of Zinc Supplementation on Thyroid Hormone Function

Nutrition for Older Athletes: Focus on Sex-Differences

Contact Info

Product

Resources

About