Basal plasma hormone levels in depressed perimenopausal women

Schmidt, Peter J.; Murphy, Jean; Haq, Nowreen; Danaceau, Merry A.; Clair, Linda Simpson St.

doi:10.1016/s0306-4530(02)00004-5

Cited by 100 publications

(73 citation statements)

References 49 publications

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“…Freeman et al 3 observed that the increased risk for first onset depression during the perimenopause was independent of the presence of hot flushes. Previous studies also have reported that perimenopausal depressed women with hot flushes are not distinguished from those without by their therapeutic responses to either estradiol therapy or selective serotonin reuptake inhibitors (SSRIs), 14;17-24 their profiles of basal plasma hormone levels (with the exception of plasma FSH levels, 25 ), or their reports of negative life events. 26 Thus although hot flushes are frequent occurrences in depressed perimenopausal women (as they also are in non-depressed perimenopausal women), hot flushes are not necessary accompaniments of depression.…”

Section: Discussionmentioning

confidence: 99%

A Cross-Sectional Evaluation of Perimenopausal Depression

Steinberg

Rubinow²,

Bartko³

et al. 2008

J. Clin. Psychiatry

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Objective-Overall, the clinical spectrum of depression during the perimenopause is not well characterized. This cross-sectional study examined the following: 1) clinical characteristics of women who presented to the NIMH midlife mood disorders clinic (between March 1990 and January 2004) with perimenopausal major and minor depressions; 2) the impact on these measures of either a prior episode of depression or the presence of hot flushes.Method-Historical variables, reproductive status, symptom ratings, and plasma hormone measures were examined in 116 women who met research criteria for perimenopause-related depression (a current episode of major or minor depression according to the Structured Clinical Interview for DSM-IV or Primary Care Evaluation of Mental Disorders supplemented with a past history form).Results-Clinical characteristics did not differ in those women with first onset (39%) versus recurrent depressions or in those with (57%) and without hot flushes. Depressive episodes clustered in the later stages of the menopause transition and the first year postmenopause. Seven (6%) women reported a past postpartum major depression, and 55% of women reported a history of premenstrual dysphoria (PMD).Conclusions-We found no evidence that either hot flushes or a previous episode of depression conveys a distinct clinical profile in these women. The clustering of onsets of depression suggests that the hormone events that characterize the late menopause transition may be relevant to the onset of this form of depression. Finally, although we observed a high rate of PMD, neither postpartum depression nor PMD are consistent accompaniments of perimenopausal depression.

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Section: Discussionmentioning

confidence: 99%

A Cross-Sectional Evaluation of Perimenopausal Depression

Steinberg

Rubinow²,

Bartko³

et al. 2008

J. Clin. Psychiatry

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“…Two cross-sectional studies showed an inverse relationship between serum levels of dihydroepiandrosterone sulfate (DHEAS) and depression [69,70], while longitudinal studies found either no significant association [55] or a positive association between DHEAS levels and depressive symptoms during the menopause transition [71].…”

Section: Hormone Associations With Depression In the Menopause Transimentioning

confidence: 99%

Depression in the menopause transition: risks in the changing hormone milieu as observed in the general population

Freeman

2015

womens midlife health

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There is accumulating evidence but no definitive answers about the incidence of depressed mood in the menopause transition and its association with the changing hormonal milieu. While a changing hormonal milieu is the natural condition for all women, only a minority of mid-life women experience debilitating depressive symptoms or clinical depression. This review focuses on associations between depressed mood and the menopause transition, primarily as identified in longitudinal, population-based studies in the past decade. Further aims were to present reported associations between depressed mood and reproductive hormones in the menopause transition as evaluated in the general population and associations of depressive symptoms or clinical depression with menopausal hot flashes or poor sleep in perimenopausal women. There is evidence to support the role of the changing endocrine milieu in the development of depressed mood in the menopause transition, but the contribution of hormones as measured is small. Disentangling the numerous factors that are associated with depression in midlife women is a major challenge for research and for clinical care, where treatments are needed to improve the most distressing menopausal symptoms.

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“…[10][11][12] However, there are no data investigating the relationship between ovarian reserve tests and mood and anxiety disorders in infertile women. Fertility and age have always had intimate relationship and the age of the female partner still remains the single most important success factor in predicting the result of treatment.…”

Section: Discussionmentioning

confidence: 99%

“…9 Up until this time, research has been made on associations between endogenous hormones and depressive mood in postmenopausal or premenopausal woman in relation with ovarian aging. [10][11][12] However, there are no data investigating the relationship between ovarian reserve tests and mood and anxiety disorders in infertile women. In the present study we aimed to investigate whether there was an association between ovarian reserve tests and depression and anxiety scales in infertile women.…”

mentioning

confidence: 99%

Is There a Relationship Between Ovarian Reserve Tests with Depression and Anxiety Scales?

Altınkaya¹,

Avcıoğlu²,

Küçük³

et al. 2017

Turkiye Klinikleri J Gynecol Obst

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A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : An important point at issue has been shown by the possible causal connection between psychopathology and infertility. The aim of the present study was to investigate whether there was an association between ovarian reserve tests and depression and anxiety scales. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : A total of 50 women, who attended the infertility clinic of Adnan Menderes University Hospital, with primary infertility, were eligible for the study. Anti-mullerian hormone (AMH), follicle stimulating hormone, luteinizing hormone and estradiol levels were assessed for establishing ovarian reserve. All participants fulfilled standardized questionnaires evaluating depression Beck Depression Inventory (BDI) and anxiety Beck Anxiety Inventory (BAI). Multiple Linear Regression analyses were used to determine the best independent predictor(s) which affected on both BDI and BAI levels. R Re es su ul lt ts s: : Both depression and anxiety scores were positively correlated with age, body mass index (BMI), duration of infertility, and diminished ovarian reserve (p<0.05). Regression analyses showed that lower AMH levels (p<0.001), higher BMI (p<0.05) and longer duration of infertility (p<0.05) were the predictors of both higher depression and anxiety scores. C Co on n--c cl lu us si io on n: : The data of the present study have established that higher depression and anxiety scores were associated with poor ovarian reserve as well as higher BMI and longer duration of infertility, suggesting that psychological support is needed for this group of women. K Ke ey yw wo or rd ds s: : Infertility; depression; anxiety Ö ÖZ ZE ET T A Am ma aç ç: : İnfertilite ile psikopatoloji arasında önemli bağlantı olduğu düşünülmektedir. Bu çal-ışmanın amacı infertil hastalarda depresyon ve anksiyeteyi ölçekler vasıtasıyla değerlendirip bu öl-çeklerin over rezerv testleriyle ilişkisini araştırmaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışmaya infertilite şikayeti ile başvuran 50 primer infertil hasta dahil edildi. Over rezervinin değerlendirilmesi amacıyla anti-müllerian hormon (AMH), siklusun 2-3-4'üncü günlerinde folikül stimülan hormon (FSH), lüteinizan hormon (LH), östradiol (E2) düzeyleri çalışıldı. Beck depresyon (BDI) ve Beck anksiyete (BAI) ölçekleri anket yöntemiyle doldurtuldu. Çoklu lineer regresyon analizleri ile bu ölçeklere etki eden en iyi bağımsız prediktörler tespit edildi. B Bu ul lg gu ul la ar r: : Hem depresyon hem de anksiyete skorları yaş, beden kitle indeksi (BKİ), infertilite süresi ve azalmış over rezervi ile pozitif korelasyon gösterdi (p<0,05). Regresyon analizi sonuçlarına göre düşük AMH düzeyleri (p<0,001), yüksek BKİ (p<0,05) ve infertilite süresinin uzunluğu (p<0,05) yüksek anksiyete ve depresyon skorları için en iyi prediktörler olarak belirlendi. S So on nu uç ç: : Bu çalışmanın sonuçlarına göre yüksek anksiyete ve depresyon skorları düşük over rezervi, yüksek BKİ ve infertilite süresinin uzunluğu ile ilişkilidir. K...

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Basal plasma hormone levels in depressed perimenopausal women

Cited by 100 publications

References 49 publications

A Cross-Sectional Evaluation of Perimenopausal Depression

A Cross-Sectional Evaluation of Perimenopausal Depression

Depression in the menopause transition: risks in the changing hormone milieu as observed in the general population

Is There a Relationship Between Ovarian Reserve Tests with Depression and Anxiety Scales?

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