Basaloid-Squamous Carcinoma of the Esophagus: Report of a Case

Abstract

We report herein the case of a 69-year-old man with basaloid-squamous carcinoma (BSC) of the esophagus. To the best of our knowledge, this is the 60th case of BSC of the esophagus to be reported in Japan, and a review of the other 59 cases is presented after this case report. In our patient, endoscopic findings revealed a circumferential erosion in the middle intrathoracic esophagus (Im), and a protruding tumor with friable ulceration in the center of the erosion. A biopsy suggested that it was moderately differentiated squamous cell carcinoma (SCC), and a thoracoscopic total thoracic esophagectomy was performed. Histologically, the protruding-type lesion with ulceration was composed of BSC, and the circumferential 0 -I + IIc type lesion was composed of moderately differentiated SCC. The immunohistochemical findings of these resected specimens led us to suspect that the basal-layer-type SCC had transformed into BSC by undergoing differentiation and expansive proliferation.

Is basaloid squamous carcinoma of the esophagus high-grade malignancy? A report of six cases

“…The growth pattern of BSCE is downward and expansive even at an early stage [15] . Superficial BSCE shows a submucosal tumor-like form or polypoid elevation [16,17] .…”

Preoperative chemoradiotherapy and surgery for locally advanced esophageal basaloid squamous carcinoma: report of successful

“…Since Yamamoto et al reported the first case of BSC of the esophagus in 1979 [2], approximately 60 cases of BSC have been reported, mainly from Japanese institutions [3][4][5][6][7][8]. The prognosis of BSC is poor, but it remains controversial compared with SCC.…”

“…On the other hand, Zhang et al described that the severe survival rate of BSC was 20% after 2 years for resected 16 patients treated with or without adjuvant chemotherapy [9]. In general, locally advanced BSC is regarded as a therapeutically resistant disease associated with a poor prognosis [3][4][5][6][7][8][9].…”

Carcinoma basalóide escamoso: uma forma rara e agressiva de câncer do esôfago e revisão da literatura

“…O paciente apresentou acentuada queda do estado geral e evoluiu para óbito com quadro de melena, quatro meses após o diagnóstico. , o carcinoma basalóide escamoso é mais freqüente em homens com idade acima de 40 anos e no terço médio do esôfago torácico 2,4,5,13 . Tais características sobrepõem-se às observadas no presente caso, exceto para o local da lesão, que estava situada no terço distal do esôfago, coincidindo com o referido por Albuquerque et al (2006) .…”

“…Este tipo de neoplasia ocorre com maior freqüência no trato aerodigestivo superior, tendo como sítios primários preferenciais a cavidade oral, faringe, laringe, seio piriforme e traquéia 5,8,14 . A incidência desta lesão no esôfago é extremamente rara, corresponde a 0,1 a 5% das neoplasias malignas do esôfago 1,6,11,15 .…”