Basaloid squamous carcinoma of the oesophagus: a distinct neoplasm with multipotential differentiation

Abstract

Basaloid squamous carcinoma of the oesophagus is a peculiar neoplasm with a capacity of multidirectional differentiation, often with heterogeneous oncogene expression, probably reflecting the pluripotential stem cell origin.

Clinical Outcomes of Basaloid Squamous Cell Carcinoma of the Esophagus: A Retrospective Analysis of 142 Cases

“…However, several recent reports (Li et al, 2004;Kobayashi et al, 2009) have demonstrated that BSCCE was accompanied by various histopathological components including ductal differentiation, myoepithelial cells, and adenoid cystic carcinoma-like features in some cases. Furthermore, some BSCCE had concomitant in situ or invasive SCC components and even the presence of small cell carcinoma (Cho et al, 2000), and therefore requires careful differentiation. Some reporters (Sarbia et al, 1997;Morice et al, 1998;Cho et al, 2000) have stated that the immunoreactivities for cytokeratin subtypes, Bcl-2, beta-catenin, S-100, and neuroendocrine markers, are different among these tumors and might assist in the distinction.…”

“…Furthermore, some BSCCE had concomitant in situ or invasive SCC components and even the presence of small cell carcinoma (Cho et al, 2000), and therefore requires careful differentiation. Some reporters (Sarbia et al, 1997;Morice et al, 1998;Cho et al, 2000) have stated that the immunoreactivities for cytokeratin subtypes, Bcl-2, beta-catenin, S-100, and neuroendocrine markers, are different among these tumors and might assist in the distinction. However, none of these markers are specific for BSCCE.…”

“…Cho et al (2000) and Lam et al (2001) reported that up to 66.7%-76.7% of the BSCCE had regional lymph node metastases. This rate was found to be 41.5% in this study.…”

Surgical Resection of a Solitary Pulmonary Metastasis from Basaloid Squamous Cell Carcinoma of the Esophagus: A Case Report

“…The incidences of BSCC differ according to reports, ranging from 0.77% to 5% in Asian groups [1][2][3][4][5][6] and from 6.9% to 11.3% in Western groups. 7,8) In 332 esophageal cancer cases who underwent surgical resection at our department between 1987 and 2010 nine cases (2.7%) were diagnosed as BSCC.…”

Carcinoma basalóide escamoso: uma forma rara e agressiva de câncer do esôfago e revisão da literatura

“…O carcinoma basalóide escamoso (CBE) é uma variante incomum do carcinoma de células escamosas do esôfago (CEC), com características clínicas próprias, sendo a alta agressividade biológica e o mau prognóstico os atributos de maior destaque 2,4,10 . Este tipo de neoplasia ocorre com maior freqüência no trato aerodigestivo superior, tendo como sítios primários preferenciais a cavidade oral, faringe, laringe, seio piriforme e traquéia 5,8,14 .…”