Base excess and lactate as prognostic indicators for patients admitted to intensive care

Smith, Iain M; Kumar, P. Vijaya; Molloy, Síle F.; Rhodes, Andrew; Newman, P. J.; Grounds, RM; Bennett, E. D.

doi:10.1007/s001340051352

Cited by 335 publications

(270 citation statements)

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“…Lactate is one of the most frequent and easily assessed parameters used in shock and other critical diseases (15). Higher lactate values must be considered as a useful indicator in identifying the severity of diseases and mortality rates (16)(17)(18)(19). On the contrary, some studies showed the first lactate values as a weak indicator of mortality (20).…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Red Cell Distribution Width in Critically Ill Patients and Comparison with Intensive Care Unit Scoring Systems

Visneci¹,

Cander²,

Gül³

et al. 2017

EAJEM

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Section: Discussionmentioning

confidence: 99%

Prognostic Value of Red Cell Distribution Width in Critically Ill Patients and Comparison with Intensive Care Unit Scoring Systems

Visneci¹,

Cander²,

Gül³

et al. 2017

EAJEM

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“…The functions of the lung parenchyma, measured by the p a O 2 , S a O 2 and p A-a O 2 parameters, did not change in both groups of animals monitored. Metabolic acidosis accompanies the development of SIRS and the analysis of blood gases and/or parameters of anaerobic metabolism, as confirmed by prior studies, may be suitable not only for the evaluation of the actual state of the patient but also for prognostic purposes (Smith et al, 2001;Marecaux et al, 1996). The increased anion gap values in the SS group at the end of the experiment correspond with the metabolic acidosis and the drop in the concentration of bicarbonates.…”

Section: Discussionmentioning

confidence: 54%

Model of septic shock induced by live E. coli (O18) in a laboratory rat

Dembovska¹,

Svoboda²,

Scheer³

et al. 2008

Vet. Med. - Czech

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ABSTRACT:This study was concerned with the development of induced septic shock in a laboratory rat using a series of measurements including body temperature, heart and respiratory rates, haematocrit value, red and white blood cell counts, differential leukocyte count, haemoglobin value, glycaemia, analysis of arterial blood gases, and serum levels of interleukin 6 (IL-6) during the first five hours. A total of 12 specific pathogen free (SPF) laboratory rats were used for the study. Septic shock was induced under general anaesthesia by introducing live E. coli (O18) into the jugular vein in the dose of 1 × 10 9 per 100 g of body weight (group SESH). Clinical measurements and blood collection from a. carotis were performed just prior to, and then 1.5 and 5 h after the administration of E. coli. The control group (C) contained 9 SPF laboratory rats which received physiological saline only, at the same volume into the jugular vein, and blood collection followed according to the same scheme as above described for group SESH. The results of the experiment showed that changes in clinical, haematological and biochemical parameters could be detected as early as 1.5 hours after induction. These changes correspond with the activation of an inflammatory reaction and the development of metabolic acidosis. They are accompanied by a considerable rise in IL-6 already 1.5 h after the application of live E. coli and after 5 h the levels exceeded 2 000 pg/ml in all experimental animals. Our results clearly document the importance of IL-6 for the early detection of developing septic shock and of some less specific but routinely determined parameters such as white blood cell count and base excess.

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“…BE is thought to represent the presence of unmeasured anions and is usually taken as a surrogate marker of lactic acidosis (12). Several studies have demonstrated an association between BE and severity in ARDS patients but most of the studies have usually failed to identify the effects that causative anions like lactate have on their resulting BE, AG, pO 2 and pCO 2 in critically ill patients (13,14). In our study, lactate correlating positively with anion gap and negatively with BE shows that lactate, like BE would be a marker of tissue hypoxia and illness severity in patients of septic shock with ARDS.…”

Section: Discussionmentioning

confidence: 99%

Plasma lactate as prognostic marker of septic shock with acute respiratory distress syndrome

Nanda

Suresh

2009

Indian J Clin Biochem

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Base excess and lactate as prognostic indicators for patients admitted to intensive care

Abstract: Both base excess and lactate, or the combination of the two, can be used to predict outcome in patients admitted to the intensive care unit. These variables could be utilized to identify patients who have a high risk for mortality and thus who should be admitted to the intensive care unit.

Cited by 335 publications

References 0 publications

Prognostic Value of Red Cell Distribution Width in Critically Ill Patients and Comparison with Intensive Care Unit Scoring Systems

Prognostic Value of Red Cell Distribution Width in Critically Ill Patients and Comparison with Intensive Care Unit Scoring Systems

Model of septic shock induced by live E. coli (O18) in a laboratory rat

Plasma lactate as prognostic marker of septic shock with acute respiratory distress syndrome

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