Baseline blood trihalomethanes, semen parameters and serum total testosterone: A cross-sectional study in China

Zeng, Qiang; Li, Min; Xie, Shao-Hua; Gu, Longjie; Yue, Jing; Cao, Wencheng; Zheng, Dan; Liu, Ailin; Li, Yufeng; Lu, Wen-Qing

doi:10.1016/j.envint.2013.01.016

Cited by 61 publications

(26 citation statements)

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“…This discrepancy might be attributed to the different study populations and the different exposure assessments (including the potentially different exposure levels). In recent studies, we used biomarkers of DBP exposures, including THMs in whole blood and TCAA in urine, to improve our assessment of exposure (Xie et al 2011; Zeng et al 2013). We found evidence suggestive of an association between elevated urinary TCAA levels and decreased sperm motility.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies used DBP concentrations in water distribution systems as surrogates of exposure, which may result in misclassification of exposure and bias the observed associations (Fenster et al 2003; Luben et al 2007). In recent studies, we used DBP biomarkers to improve the assessment of exposure and found a potential relationship between DBP exposure and decreased semen quality (Xie et al 2011; Zeng et al 2013). However, limited sample sizes in our previous studies have often been insufficient to produce precise results (Nieuwenhuijsen et al 2009).…”

Section: Introductionmentioning

confidence: 99%

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Drinking-Water Disinfection By-products and Semen Quality: A Cross-Sectional Study in China

Zeng

Wang

Xie

et al. 2014

Environ Health Perspect

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Background: Exposure to disinfection by-products (DBPs) has been demonstrated to impair male reproductive health in animals, but human evidence is limited and inconsistent.Objective: We examined the association between exposure to drinking-water DBPs and semen quality in a Chinese population.Methods: We recruited 2,009 men seeking semen analysis from the Reproductive Center of Tongji Hospital in Wuhan, China, between April 2011 and May 2012. Each man provided a semen sample and a urine sample. Semen samples were analyzed for sperm concentration, sperm motility, and sperm count. As a biomarker of exposure to drinking-water DBPs, trichloroacetic acid (TCAA) was measured in the urine samples.Results: The mean (median) urinary TCAA concentration was 9.58 (7.97) μg/L (interquartile range, 6.01–10.96 μg/L). Compared with men with urine TCAA in the lowest quartile, increased adjusted odds ratios (ORs) were estimated for below-reference sperm concentration in men with TCAA in the second and fourth quartiles (OR = 1.79; 95% CI: 1.19, 2.69 and OR = 1.51; 95% CI: 0.98, 2.31, respectively), for below-reference sperm motility in men with TCAA in the second and third quartiles (OR = 1.46; 95% CI: 1.12, 1.90 and OR = 1.30; 95% CI: 1.00, 1.70, respectively), and for below-reference sperm count in men with TCAA in the second quartile (OR 1.62; 95% CI: 1.04, 2.55). Nonmonotonic associations with TCAA quartiles were also estimated for semen parameters modeled as continuous outcomes, although significant negative associations were estimated for all quartiles above the reference level for sperm motility.Conclusion: Our findings suggest that exposure to drinking-water DBPs may contribute to decreased semen quality in humans.Citation: Zeng Q, Wang YX, Xie SH, Xu L, Chen YZ, Li M, Yue J, Li YF, Liu AL, Lu WQ. 2014. Drinking-water disinfection by-products and semen quality: a cross-sectional study in China. Environ Health Perspect 122:741–746; http://dx.doi.org/10.1289/ehp.1307067

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Drinking-Water Disinfection By-products and Semen Quality: A Cross-Sectional Study in China

Zeng

Wang

Xie

et al. 2014

Environ Health Perspect

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“…Using urinary trichloroacetic acid as a marker of exposure, increased exposure was associated with lower sperm concentrations in Chinese men (Zeng et al ., ). A separate study in China found a trend toward lower sperm concentrations with higher serum trihalomethane levels (Zeng et al ., ). Three studies, however, found no significant effect of trihalomethane exposure on sperm counts (Fenster et al ., ; Luben et al ., ; Iszatt et al ., ).…”

Section: Ambient and Other Occupational Exposuresmentioning

confidence: 97%

Chronic exposures and male fertility: the impacts of environment, diet, and drug use on spermatogenesis

2016

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SUMMARYSeveral recent studies have suggested that sperm concentrations and semen quality have been decreasing over the past several decades in many areas of the world. The etiology of these decreases is currently unknown. Acute events can have significant impacts on spermatogenesis and are often readily identified during the male fertility evaluation. The majority of male factor infertility, however, is idiopathic. Chronic, low-dose exposures to chemicals and nutrients are more difficult to identify, but are extremely prevalent. These exposures have been shown to have dramatic effects on both individual and community health and interest in the cumulative and synergistic impacts of such agents on spermatogenesis has been increasing. While our understanding of these potential hazards is evolving, it is clear that they may significantly influence male reproductive potential. This review explores the literature related to effects of chronic exposures from drug use, dietary intake, and the environment on spermatogenesis in humans and animals.

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“…3 in the air and from 17 to 291 ng/L in blood samples Zeng, Li, Xie, Gu, Yue, Zheng, Liu, Li, and Lu (2013). correlated THM levels in blood samples of 401 men varied with the halogen, with iodoacetic acid having a stronger effect than bromoacetic acid, which has a much strong effect than chloroacetic acid.…”

mentioning

confidence: 95%

Disinfection Processes

Munakata

Kuo

2014

Water Environment Research

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Baseline blood trihalomethanes, semen parameters and serum total testosterone: A cross-sectional study in China

Cited by 61 publications

References 39 publications

Drinking-Water Disinfection By-products and Semen Quality: A Cross-Sectional Study in China

Drinking-Water Disinfection By-products and Semen Quality: A Cross-Sectional Study in China

Chronic exposures and male fertility: the impacts of environment, diet, and drug use on spermatogenesis

Disinfection Processes

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