Basement membrane in hepatic coccidiosis of the rabbit

Chen, C.M.C.; Tsai, L.-C.; Chung, Carol; Han, Shou‐Hwa

doi:10.1016/0021-9975(72)90026-6

Cited by 5 publications

(3 citation statements)

References 3 publications

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“…The base membrane serves as a limiting substratum to support the overlying epithelium. The large branching hyperplastic epithelium was thought to need a comparatively thicker basement membrane for its support (Chen et al, 1972). In the opinion of authors the thickened basement membrane appears to be a defensive act on part of the host against coccidial infection.…”

Section: Discussionmentioning

confidence: 99%

Pathological changes and local defense reaction occurring in spontaneous hepatic coccidiosis in rabbits (Oryctolagus cuniculus).

Darzi¹,

Mir²,

Kamil³

et al. 2010

World rabbit sci.

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Hepatic coccidiosis occurred in 56 rabbits belonging to different ages, sexes and breeds during the years from 2002 to 2005. Clinically, the severely affected rabbits showed decreased growth rate, anorexia, debilitation, listlessness, diarrhea, icterus and rough hair coat. Postmortem examinations revealed increased dirty dull straw colored peritoneal fluid. Hepatomegaly, with presence of discrete yellowish-white nodules of 1mm to 1 cm size on the surface and throughout the parenchyma, was seen. Smears from peritoneal fluid showed rafts of mesothelial cells. Impression smears from the liver nodules revealed presence of numerous developmental stages of Eimeria stiedae corresponding with the stage of the liver lesion. These were intermixed with sheats of hepatobiliary cells and inflammatory cells and the changes were reflective of the histological changes like biliary hyperplasia, cholangitis and vacuolar changes occurring in the liver. There was increase in the thickness of basement membrane with the advanced stage of the lesion. The basement membrane was up to 1-2 µm in thickness forming loop like structures over which resided hyperplastic biliary cells containing different stages of the parasite. Some thickened basement membranes were devoid of overlying cells which had desquamated and were present in the ductal lumens suggesting that the basement might have the local defensive role in warding off the coccidial infection. The basement membrane was positive for neutral mucopolysaccharides while as the inflammatory zones and biliary epithelia along with the gametogonic stages of the coccidium reacted positively to the increased acid mucopolysaccharides qualitatively. The results showed that the occurrence of hepatic coccidiosis in female rabbits coincided with the breeding and kindling periods. Direct wet mount smears from bile aid in diagnosis of the disease. Impression smears from the liver nodules might represent the histological changes in the liver. The basement membrane thickening might have a defensive role in warding off the coccidial infection.

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Section: Discussionmentioning

confidence: 99%

Pathological changes and local defense reaction occurring in spontaneous hepatic coccidiosis in rabbits (Oryctolagus cuniculus).

Darzi¹,

Mir²,

Kamil³

et al. 2010

World rabbit sci.

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“…Developmental forms of the parasite are seen in the bile duct epithelial cells, and oocysts appear in the lumen. The liver parenchyma is destroyed by pressure from expanding biliary ducts and is gradually replaced by fibrous connective tissue 1,7,13 …”

Section: Discussionmentioning

confidence: 99%

“…It has a flat micropylar end, a smooth bright‐pink wall, and a micropyle, but no polar granules or residuum. The 4 sporocysts are ovoid, contain 2 sporozoites each, and have a residuum 1,7,13,14 . Sporozoites penetrate the mucosa of the small intestine and pass via the mesenteric lymph nodes and hepatic portal system to the liver.…”

Section: Discussionmentioning

confidence: 99%

Impression Smear of Liver Tissue from a Rabbit

Al-Rukibat¹,

Irizarry²,

Lacey³

et al. 2001

Veterinary Clinical Pathol

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Spontaneous “primary biliary cirrhosis” in rabbits

Tison¹,

Callea²,

Morisi³

et al. 1982

Liver

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ABSTRACT— A syndrome resembling human Primary Biliary Cirrhosis (PBC) and occurring spontaneously in a strain of domesticated rabbits from the Faenza region in Italy, is reported. The syndrome is characterized by histological liver changes consisting of chronic non‐suppurative destructive cholangitis and copper accumulation, biochemical and immunological abnormalities mainly represented by an elevation of serum alkaline phosphatase and a positive antimitochondrial antibody test. The abnormalities were not observed in newborn rabbits from the same area nor in control rabbits from the island of Sardinia. A toxic effect related to some environmental factor may be responsible for the disease. Alternatively, a continuous process of partial inbreeding among consanguineous animals may have resulted in a selection of a strain genetically predisposed to the development of PBC. Whatever the etiology, the domesticated Faenza rabbit proves to be an interesting animal model for a chronic non‐suppurative destructive cholangitis, very similar to the human disease known as PBC.

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Basement membrane in hepatic coccidiosis of the rabbit

Cited by 5 publications

References 3 publications

Pathological changes and local defense reaction occurring in spontaneous hepatic coccidiosis in rabbits (Oryctolagus cuniculus).

Pathological changes and local defense reaction occurring in spontaneous hepatic coccidiosis in rabbits (Oryctolagus cuniculus).

Impression Smear of Liver Tissue from a Rabbit

Spontaneous “primary biliary cirrhosis” in rabbits

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