Bases moleculares de la infección asociada a implantes ortopédicos

Detection of mecA Genes in Hospital-Acquired MRSA and SOSA Strains Associated with Biofilm Formation

“…It has been shown that some SOSA strains can produce biofilm through the expression of genes ica , Aap , and bap ; the latter was reviewed for the strains of this study, but no strain was amplified; this may be because the strains in which it has been reported have been from veterinary studies, and those shown here are from clinical isolates, or because biofilm production is due to other genes not described in this study [ 73 , 74 , 75 , 76 , 77 ].…”

“…However, in various studies, only icaA and icaD were amplified. In these positive strains, there was PIA formation; however, it has been evaluated that the presence of the entire operon acts together to increase biofilm production [ 74 , 76 , 77 ]. As mentioned, biosynthesis genes clustered in the ica operon contribute to the formation of biofilms; they have been identified in S. epidermidis , S. aureus , Bacillus subtilis , and in many Gram-negative bacteria [ 78 ].…”

“…Although the ica operon has been the most studied, in the literature, it is found that of the strains that produce biofilm, only 30% present high levels of PIA in vitro; the fact that PIA is not detected, could be present at levels not detectable or even absent, may suggests that the biofilms are composed mainly of teichoic acid and other protein components [ 74 , 79 ].…”

Extensive humeral defect secondary to humeral shaft nonunion and chronic osteomyelitis treated with induced membrane technique augmented with fibula autograft: a case report

“…Staphylococcus aureus and Coagulase-negative staphylococci are, by far, the most frequently involved microorganisms associated with bone osteomyelitis because of their ability to form biofilms, which are difficult to treat solely with antimicrobial agents. 5 , 26 Other resistant strains are not frequent and account for only 0.24%. 23 Identification of the microorganism involved is difficult.…”

Readmissão por infecção do sítio cirúrgico ortopédico: um enfoque fenomenológico

“…A ortopedia é a especialidade na qual a maioria das infecções se associa ao uso de implantes, com estudos que sinalizam a possibilidade de aumento progressivo de sua ocorrência (Contreras;Sepúlveda, 2014). A intensidade na utilização de implantes deve ser considerada quando se observa a elevação da expectativa de vida nas últimas décadas, e a infecção relacionada passa a constituir um dos eventos não esperados (Goveia et al, 2015).…”