Basic fibroblast growth factor slow release stent graft for endovascular aortic aneurysm repair: A canine model experiment

Kajimoto, Masaki; Shimono, Takatsugu; Hirano, Kōji; Miyake, Yoichiro; Kato, Noriyuki; Imanaka‐Yoshida, Kyoko; Shimpo, Hideto; Miyamoto, Keiichi

doi:10.1016/j.jvs.2008.05.060

Cited by 12 publications

(12 citation statements)

References 33 publications

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“…Therefore, the aneurismal model suitable for the research of branched stent graft should be adjacent to or involve the left subclavian artery. Recently, all the animal models of thoracic aortic aneurysm were situated in the medial segment of the descending thoracic aorta, [14][15][16] while the average distance between our aneurismal model and the left subclavian artery was 8.29 ± 0.91 mm. Thus, the aneurismal model is suitable for the research of new branched stent grafts.…”

Section: Discussionmentioning

confidence: 88%

“…The acquirement of jugular vein patches by Kajimoto et al increased the extent of trauma and risk for infection. 16) In our surgical procedure, the left third-fourth intercostal thoracotomy could expose the proximal descending thoracic aorta and the pericardium sufficiently. Therefore, all the manipulation could be finished through the thoracotomy.…”

Section: Discussionmentioning

confidence: 98%

“…15) Kajimoto et al used jugular vein patches to create thoracic aortic aneurysms in beagles. 16) For Fig. 2 The volume rendering images of the aneurismal model (white arrow).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the thoracic aorta was completely clamped in the surgical procedure of other aneurismal models. [14][15][16] That may increase the risk of distal infarction. We clamped the anterolateral wall of the thoracic aorta.…”

Section: Discussionmentioning

confidence: 99%

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A Canine Model of Proximal Descending Thoracic Aortic Aneurysm Created with an Autologous Pericardial Patch

et al. 2013

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Objectives: To establish an animal model of proximal descending thoracic aortic aneurysm for the study of branched stent grafts. Materials and Methods: Eleven mongrel dogs underwent the surgical procedure during which an autologous pericardial patch was sewn onto a longitudinal incision in the anterolateral wall of the thoracic aorta near the left subclavian artery to create an artificial thoracic aortic aneurysm. Results: All eleven animals survived the surgical procedure. One animal died from rupture at the surgical site during the first week after surgery. The distance between the artificial aneurysm and the left subclavian artery was 8.29 ± 0.91 mm. The average diameter of the artificial aneurysms did not significantly change over the 4-month follow-up period. Conclusion: A canine model for proximal descending thoracic aortic aneurysm can be achieved using a safe and convenient method. The model can be used in the study of new branched stent graft applied to the aortic arch.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 98%

“…15) Kajimoto et al used jugular vein patches to create thoracic aortic aneurysms in beagles. 16) For Fig. 2 The volume rendering images of the aneurismal model (white arrow).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A Canine Model of Proximal Descending Thoracic Aortic Aneurysm Created with an Autologous Pericardial Patch

et al. 2013

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“…Achieving early neo-endothelialization and tight attachment to the native aorta were regarded as important goals for developing ideal aortic stent grafts. Regarding previous studies, several reports have described early results for basic fibroblast growth factor (bFGF)-releasing aortic stent grafts that were implanted into animal models [19,20]. In these studies, the bFGF-releasing aortic stent grafts significantly accelerated the proliferation of neointimal tissue when compared with the control models.…”

Section: Discussionmentioning

confidence: 99%

Implantation study of a tissue-engineered self-expanding aortic stent graft (bio stent graft) in a beagle model

et al. 2014

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The use of stent grafts for endovascular aortic repair has become an important treatment option for aortic aneurysms requiring surgery. This treatment has achieved excellent outcomes; however, problems like type 1 endoleaks and stent graft migration remain. Bio stent grafts (BSGs), which are self-expanding stents covered with connective tissue, were previously developed using "in-body tissue architecture" technology. We assessed their early adaptation to the aorta after transcatheter implantation in a beagle model. BSGs were prepared by subcutaneous embedding of acryl rods mounted with self-expanding nitinol stents in three beagles for 4 weeks (n = 3/dog). The BSGs were implanted as allografts into infrarenal abdominal aortas via the femoral artery of three other beagles. After 1 month of implantation, aortography revealed no stenosis or aneurysmal changes. The luminal surface of the BSGs was completely covered with neointimal tissue, including endothelialization, without any thrombus formation. The cover tissue could fuse the luminal surface of the native aorta with tight conjunctions even at both ends of the stents, resulting in complete impregnation of the strut into the reconstructed vascular wall, which is expected to prevent endoleaks and migration in clinical applications.

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Development of a stent capable of the controlled release of basic fibroblast growth factor and argatroban to treat cerebral aneurysms: In vitro experiment and evaluation in a rabbit aneurysm model

et al. 2019

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An ideal stent to treat cerebral aneurysms should have an antithrombotic effect on the inner stent blood-facing side and a tissue organization effect on the outer aneurysmal side of the stent. The objective of this study is to evaluate the feasibility of a drug containing stent in the in vivo treatment of cerebral aneurysms. Argatroban, an antithrombotic drug, is encapsulated in biodegradable poly (D,L-lactide-co-glycolide) (PLGA) microspheres for the controlled release with an in vitro study conducted to evaluate the drug release and anticoagulation behavior of released drug. Basic fibroblast growth factor (bFGF), an organization drug, is released from gelatin hydrogels. The stents are coated with gelatin hydrogels incorporating bFGF and PLGA microspheres containing argatroban, and applied to the carotid artery aneurysm of an elastase-induced rabbit model. Most of the aneurysm cavity is occupied by loose connective tissues in the group treated with drug-coated stents, whereas extensive massive hematomas are observed in the group treated with drug-free stents. The occurrence rate of in-stent thrombus is small in the drug-coated stents. The stent incorporating bFGF and PLGA microspheres containing argatroban is an effective device for cerebral aneurysm treatment.

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Basic fibroblast growth factor slow release stent graft for endovascular aortic aneurysm repair: A canine model experiment

Abstract: bFGF-S/Gs are effective for accelerating organization of the aneurysm cavity and developing neointima. Further research on bFGF-S/Gs would clarify the association of endoleaks.

Cited by 12 publications

References 33 publications

A Canine Model of Proximal Descending Thoracic Aortic Aneurysm Created with an Autologous Pericardial Patch

A Canine Model of Proximal Descending Thoracic Aortic Aneurysm Created with an Autologous Pericardial Patch

Implantation study of a tissue-engineered self-expanding aortic stent graft (bio stent graft) in a beagle model

Development of a stent capable of the controlled release of basic fibroblast growth factor and argatroban to treat cerebral aneurysms: In vitro experiment and evaluation in a rabbit aneurysm model

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